Objective To explore the effectiveness of expanded curettage in the treatment of chondroblastoma. Methods The clinical data of 37 patients with chondroblastoma who were treated with expanded curettage between January 2011 and May 2016 were retrospectively analyzed. There were 24 males and 13 females, with a median age of 17 years (range, 12-30 years). There were 32 primary patients and 5 recurrent patients. Local pain was the first symptom in all patients. The average disease duration was 4.9 months (range, 2-8 months). The lesions were located in the distal femur in 10 cases, the proximal femur in 7 cases, the proximal tibia in 9 cases, the proximal humerus in 5 cases, the patella in 2 cases, the talus in 1 case, the calcaneus in 1 case, and pelvis in 2 cases. According to the Enneking staging of benign bone tumors, all tumors were rated as the 3rd stage. The length of the lesion ranged from 1.2 to 6.9 cm (mean, 3.2 cm). The lesions involved the epiphyseal plate in 19 cases. Results All incisions healed by first intention, and no complications occurred. All patients were followed up 12-76 months, with an average of 40.5 months. At last follow-up, the Musculoskeletal Tumor Society (MSTS) score was 27.5±1.4, and the difference was significant when compared with pre-operative value (18.5±1.9) (t=23.462, P=0.000). The chondroblastoma recurred in 1 case (2.7%) after 5 months. X-ray film showed that bone resorption was found in 6 cases, but there was no obvious collapse in the articular surface of bone graft. The limb shortening deformity occurred in 3 cases who were epiphyseal plate involvement patients and lesions located around the knee joint. But there was no varus deformity, and knee joint activity was not affected. Conclusion Expanded curettage has advantages of low incidence of recurrence and skeletal deformity, good limb function, and it is one of the ideal options for chondroblastoma.
Objective To identify the potential categories of self-awareness of falls in elderly patients with hip osteoarthritis (HOA), and to analyze the characteristics and influencing factors of different categories. Methods A cross-sectional study was conducted on elderly patients with HOA who were hospitalized in the orthopedic ward of West China Hospital of Sichuan University between February and April 2026 by convenience sampling. The participants were investigated by general information questionnaire, Self-awareness of Falls in Elderly scale, Fall Risk Self-rating Scale for the Elderly, Barthel index scale for self-care ability assessment, Family Care Index Questionnaire, Generalized Anxiety Disorder-7 self-rating scale and Berg Balance Scale. The potential categories of self-awareness of falls were divided by potential profile analysis, and the influencing factors of self-awareness of falls were explored by single factor analysis and multinomial logistic regression analysis. Results A total of 301 elderly patients with HOA were included. The self-awareness of falls of elderly patients with HOA could be divided into three potential categories: “low alertness and low cognition” “medium alertness and high cognition” and “high alertness and high cognition”. Compared with “high alertness and high cognition”, patients with lower education level [odds ratio (OR)=0.199, 95% confidence interval (CI) (0.097, 0.411), P<0.001] and fewer chronic diseases [OR=0.654, 95%CI (0.453, 0.945), P=0.024] were more likely to belong to “medium alertness and high cognition”; patients with good self-care ability [OR=0.346, 95%CI (0.192, 0.623), P<0.001], good balance ability [OR=0.119, 95%CI (0.048, 0.293), P<0.001], fewer chronic diseases [OR=0.478, 95%CI (0.292, 0.781), P=0.003], and low degree of pain [OR=0.448, 95%CI (0.276, 0.728), P=0.001] were more likely to belong to “low alertness and low cognition”. Conclusions There is group heterogeneity in the self-awareness of falls of elderly patients with HOA. In clinical work, medical staff should formulate personalized intervention strategies for different types of patients according to their different characteristics.
ObjectiveTo construct bone morphogenetic protein 2 (BMP-2) gelatin/chitosan hydrogel sustained-release system, co-implant with induced pluripotent stem cells (iPS) derived mesenchymal stem cells (MSCs) to hydroxyapatite (HA)/zirconium dioxide (ZrO2) bio porous ceramic foam, co-culture in vitro, and to explore the effect of sustained-release system on osteogenic differentiation of iPS-MSCs.MethodsBMP-2 gelatin/chitosan hydrogel microspheres were prepared by water-in-oil solution. Drug encapsulation efficiency, drug loading, and in vitro sustained release rate of the microspheres were tested. HA/ZrO2 bio porous ceramic foam composite iPS-MSCs and BMP-2 gelatin/chitosan hydrogel sustained release system co-culture system was established as experimental group, and cell scaffold complex without BMP-2 composite gelatin/chitosan hydrogel sustained release system as control group. After 3, 7, 10, and 14 days of co-culture in the two groups, ALP secretion of cells was detected; gene expression levels of core binding factor alpha 1 (Cbfa1), collagen type Ⅰ, and Osterix (OSX) were detected by RT-PCR; the expression of collagen type Ⅰ was observed by immunohistochemical staining at 14 days of culture; and cell creep and adhesion were observed by scanning electron microscopy.ResultsBMP-2 gelatin/chitosan hydrogel sustained-release system had better drug encapsulation efficiency and drug loading, and could prolong the activity time of BMP-2. The secretion of ALP and the relative expression of Cbfa1, collagen type Ⅰ, and OSX genes in the experimental group were significantly higher than those in the control group at different time points in the in vitro co-culture system (P<0.05). Immunohistochemical staining showed that the amount of fluorescence in the experimental group was significantly more than that in the control group, i.e. the expression level of collagen type Ⅰ was higher than that in the control group. The cells could be more evenly distributed on the materials, and the cell morphology was good. Scanning electron microscopy showed that the sustained-release system could adhere to cells well.ConclusioniPS-MSCs have the ability of osteogenic differentiation, which is significantly enhanced by BMP-2 gelatin/chitosan hydrogel sustained-release system. The combination of iPS-MSCs and sustained-release system can adhere to the materials well, and the cell activity is better.