Objective To review the progress of in vivo study on degradable magnesium alloys application as bone-implant materials. Methods Recent literature was extensively reviewed and summarized, concerning the in vivo study on degradable magnesium alloys as orthopaedic implants. Results Magnesium alloys possess a natural ability to degrade via corrosion in vivo, which is promising candidate material for orthopaedic medical device applications. A great progress has been made to improve in vivo performance and integration with bone tissue. However, the degradation mechanism of magnesium-based materials in the physiological environment and long-term effect on body are not available. The modulation of the corrosion rate of magnesium alloys must also be accomplished. Conclusion Magnesium alloys have the potential to serve as degradable implants for orthopaedic applications, but a great deal of further investigation is still necessary.
目的 比較外固定支架與鎖定加壓鋼板（LCP）治療橈骨遠端die-punch骨折的療效及適應證。 方法 2007年1月－2011年1月，分別采用外固定支架和LCP治療橈骨遠端die-punch骨折32例36側，其中LCP固定19側，外固定支架固定17側。兩組患者性別、年齡、致傷原因、骨折分類、傷后至入院時間等一般資料比較差異無統計學意義（P＞0.05）。術中對塌陷的關節面均采取撬撥植骨的方法恢復橈腕關節，克氏針固定較大骨折塊。比較兩種方法手術前后掌傾角、尺偏角、橈腕關節面恢復情況、骨折愈合時間，術后腕關節活動范圍等。 結果 兩組患者手術切口均Ⅰ期愈合，無感染發生。患者術后均獲隨訪，隨訪時間6～24個月，平均13個月。所有患者骨折愈合良好，愈合時間、術后6個月X線片掌傾角、尺偏角兩組間差異均無統計學意義（P＞0.05）；術后6個月腕關節尺偏活動度分別為（20.8 ± 3.6）°和（18.0 ± 2.8）°，LCP組優于外固定支架組（P＜0.05）；LCP組和外固定支架組橈骨高度分別為（10.9 ± 2.8）mm和（13.4 ± 2.3）mm，Gartland-Werley評分分別為（5.3 ± 2.4）分和（8.4 ± 3.6）分，兩組差異有統計學意義（P＜0.05）。 結論 對于橈骨遠端die-punch骨折，LCP可提供有效固定及早期活動，但對于關節面的塌陷及橈骨高度的恢復，外固定支架固定可提供良好的支撐作用。對于嚴重die-punch骨折可聯合運用LCP和外固定支架等技術。