ObjectiveTo review the advances in perioperative pain management of pediatric and adolescent spinal deformity corrective surgery.MethodsRegular analgesics, drug administrations, and analgesic regimens were reviewed and summarized by consulting domestic and overseas related literatures about perioperative pain management of pediatric and adolescent spinal deformity corrective surgery in recent years.ResultsAs for perioperative analgesis regimens of pediatric and adolescent spinal deformity corrective surgery, regular analgesics include non-steroidal anti-inflammatory drugs, opioids, antiepileptic drugs, adrenergic agonists, and local anesthetic, etc. Besides drug administration by mouth, intravenous injection, and intramuscular injection, the administration also includes patient controlled analgesia, epidural injection, and intrathecal injection. Multimodal analgesia is the most important regimen currently.ConclusionHeretofore, a number of perioperative pain managements of pediatric and adolescent spinal deformity corrective surgery have been applied clinically, but the ideal regimen has not been developed. To design a safe and effective analgesic regimen needs further investigations.
目的 研究糖尿病、陽痿、慢性腎炎患者中篩選出的典型腎陽虛證病例的轉錄組學特征，揭示出腎陽虛證“同證異治”的生物學基礎。 方法 分別對9例腎陽虛證患者進行Agilent人444k表達譜芯片實驗，對差異表達基因進行基因本休論（GO）、Pathway分析。 結果 找出332條共同差異表達基因，其中有注釋的基因為181條。通過GO分析發現腎陽虛證在免疫系統、氨基酸分解和合成、脂類代謝、生殖、能量代謝及腫瘤相關的基因有密切聯系，通過Pathway分析發現與腎陽虛證相關的信號通路有39個。 結論 腎陽虛證可能導致免疫系統低下，氨基酸分解和合成、脂類代謝、生殖、能量代謝功能降低，以及與腫瘤形成相關。