目的 觀察鹽酸氨基葡萄糖治療腰椎小關節骨關節炎的臨床療效。 方法 2010年9月－2012年5月門診就診的160例腰椎小關節骨關節炎患者隨機分為兩組進行治療，對照組80例，口服非甾體抗炎藥物尼美舒利；試驗組80例，在服用尼美舒利的基礎上加服鹽酸氨基葡萄糖，治療周期為2周。對兩組患者治療前及治療后1、2周后日常生活能力、視覺疼痛模擬、心理測評（采用癥狀自評量表檢測）3項指標進行檢測，比較兩組的臨床療效，并對患者進行3個月隨訪。 結果 兩組患者各指標檢測結果顯示，治療后較治療前均明顯改善，試驗組明顯優于對照組；總有效率試驗組為97.3%，對照組為86.1%，試驗組明顯優于對照組，組間比較差異有統計學意義（P＜0.05）。 結論 鹽酸氨基葡萄糖聯合尼美舒利治療腰椎小關節骨關節炎具有較好的臨床療效。
【Abstract】 Objective To evaluate the surgical management of rigid post-traumatic thoracolumbar kyphosis (RPTK) by simultaneous posterio-anterior circumferential releasing, correction and anterior corpectomy with preserved posterior vertebral wall. Methods Twenty patients with RPTK were treated between October 2004 and October 2010 by posterior releasing, anterior subtotal corpectomy with preserved posterior vertebral wall, correction, strut graft, and short segmental fixation. There were 14 males and 6 females with an average age of 43.2 years (range, 23-63 years). The time between injury and operation was 4 months to 23 years (mean, 1.4 years). The affected locations were T11 in 1 case, T12 in 8 cases, L1 in 10 cases, and L2 in 1 case. The Cobb angle and the intervertebral height of the fractured vertebra body were measured before and after operations. The degrees of low back pain were assessed by Japanese Orthopaedic Association (JOA) scores. Results No incision infection, nerve injury, or cerebral spinal fluid leakage occurred. Seventeen patients were followed up 1-5 years with an average of 2.8 years. The JOA score at last follow-up (26.2 ± 3.9) was significantly improved when compared with the pre-operative score (14.0 ± 5.7) (t=4.536, P=0.001). One patient had aggravation of kyphosis at 3 months postoperatively, who was in stabilized condition after prolonging immobilizated time. The Cobb angle was corrected from (43.2 ± 11.5)° preoperatively to (9.8 ± 5.7)° at last follow-up, showing significant difference (P lt; 0.01). There was significant difference in the intervertebral height of the fractured vertebra body between preoperation and last follow-up (P lt; 0.05). The intervertebral height of fractured vertebra was restored to 87.0% ± 11.2% of adjacent disc height. Conclusion Posterio-anterior circumferential releasing and anterior corpectomy with preserved posterior vertebral wall can achieve satifactory clinical results, not only in pain relieving, kyphosis correction, vertebral height restoration, and spinal stability restoration, but also in the risk reduce of bleeding and spinal cord disturbance.