Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis_West China Medical Journal

Authors：

DING Yuhui ¹ ,  LI Sen ²

1. Department of Anesthesiology; 2. Department of Spine Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding?author：

LI Sen, Email: dingyuhui1@126.com

Keywords：

鹽酸氨基葡萄糖; 骨關節炎，腰椎小關節; 臨床療效

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目的　觀察鹽酸氨基葡萄糖治療腰椎小關節骨關節炎的臨床療效。方法　 2010年9月－2012年5月門診就診的160例腰椎小關節骨關節炎患者隨機分為兩組進行治療，對照組80例，口服非甾體抗炎藥物尼美舒利；試驗組80例，在服用尼美舒利的基礎上加服鹽酸氨基葡萄糖，治療周期為2周。對兩組患者治療前及治療后1、2周后日常生活能力、視覺疼痛模擬、心理測評（采用癥狀自評量表檢測）3項指標進行檢測，比較兩組的臨床療效，并對患者進行3個月隨訪。結果　兩組患者各指標檢測結果顯示，治療后較治療前均明顯改善，試驗組明顯優于對照組；總有效率試驗組為97.3%，對照組為86.1%，試驗組明顯優于對照組，組間比較差異有統計學意義（P＜0.05）。結論　鹽酸氨基葡萄糖聯合尼美舒利治療腰椎小關節骨關節炎具有較好的臨床療效。

Citation： DING Yuhui,LI Sen. Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis. West China Medical Journal, 2012, 27(12): 1814-1817. doi: Copy

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1. 　Manchikanti L, Hirsch JA, Pampati V. Chronic low back pain of facet (zygapophysial) joint origin:is there a difference based on involvement of single or multiple spinal regions?[J]. Pain Physician, 2003, 6(4): 399-405.
2. 　ManchikantiL, Singhv PV. Is there correlation of facejoint pain in lumbar and cervical spine[J]. Pain Physician, 2002, 4(5): 365-371.
3. 　饒書城, 宋躍明. 脊柱外科手術學[M]. 3版. 北京: 人民衛生出版社, 2006: 510-515.
4. 　王家良. 臨床流行病學-臨床科研設計, 衡量與評價[M]. 2版. 上海: 上海科學技術出版社, 2001: 47-59.
5. 　劉云鵬, 劉沂. 骨與關節損傷和疾病的診斷分類及功能評定標準[M]. 北京: 清華大學出版社, 2002: 246.
6. 　Sato H, kikuchi S. The natural history of radiographic instability of the lumber spine[J]. Spine (Phila Pa 1976), 1993, 18(14): 2075-2079.
7. 　王開明, 劉運敏, 潘開昌, 等. 腰椎小關節穿刺的應用解剖[J]. 中國臨床解剖學雜志, 2007, 25(4): 397-399.
8. 　Borenstein D. Does osteoarthritis of the lumbar spine cause chroniclow back pain?[J]. Curr Pain Headache Rep, 2004, 8(6): 512-517.
9. 　Gorbach C, Schmid MR, Elfering A, et al. Therapeutic efficacy of facet joint blocks[J]. AJR Am J Roentgenol, 2006, 186(5): 1228-1233.
10. 　Sehgal N, Shah RV, Mckenzie-Brown A, et al. Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence[J]. Pain Physician, 2005, 8(2): 211-224.
11. 　李曉宏, 趙偉成, 楊承祥. 奧泰靈用于治療膝骨關節炎的臨床觀察[J]. 中國疼痛醫學雜志, 2005, 11(6): 365-366.
12. 　Gatti JC. Glucosamine treatment for osteoarthritis[J]. Am Fam Physician, 2006, 73(7): 1189-1191.
13. 　Fox BA, Schmitz ED, Wallace R. FPIN’s clinical inquiries. Glucosamine and chondroitin for osteoarthritis[J]. Am Fam Physician, 2006, 73(7): 1245-1246.
14. 　陳德生, 張志剛, 曹靖, 等. 鹽酸氨基葡萄糖對兔膝骨性關節炎的影響[J]. 中國修復重建外科雜志, 2010, 24(3): 287-291.
15. 　江相保, 高李俠. 鹽酸氨基葡萄糖治療膝退行性骨關節炎的臨床觀察[J]. 中國修復重建外科雜志, 2008, 22(1): 29-31.

West China Medical Journal

Short-term Efficacy of Glucosamine Hydrochloride Combined with Nimesulide on Lumbar Facet Joint Osteoarthritis

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