目的:β淀粉樣蛋白（β-amyloid precursor protein，β-APP）是已知的參與阿爾茨海默病機制的關鍵因子。β-APP是否參與難治性癲癇中的病理機制并不清楚。這項研究在于了解β-APP的蛋白在難治性癲癇患者術后顳葉皮質和海馬組織中的表達是否異常。方法:免疫熒光法半定量測定難治性癲癇患者術后顳葉皮質和海馬組織中的β-APP陽性蛋白的熒光值，并應用統計軟件對實驗數據進行單因素方差分析。結果:免疫熒光強度值分析結果顯示β-APP在耐藥性癲癇腦組織中表達較對照組明顯增高且有統計學意義。結論:β-APP在難治性癲癇腦組織中異常增高，增高的β-APP可能參與了難治性癲癇的病理機制。
Objective To explore the status of smoking and passive smoking of the population with the high risk of stroke in the community and their attitude towards smoking control. Methods In March 2015, under the direction of Stroke Screening and Prevention Projection, the residents with the high risk of stroke were sought out in Longfeng Community, Suining City, Sichuan Province. And then their status of smoking and passive smoking and their attitude towards smoking control was investigated by Passive Smoking Questionnaire for Adults from National Smoking Control Office. Results A total of 354 residents with the high risk of stroke were sought out, in whom 152 (42.9%) were smokers, and the smoking rate of males (70.1%) and females (1.4%) was significantly different (P<0.001). Those aged 40-49 had the highest smoking rate (55.0%), followed by those aged 50-59 (51.7%), and smokers of the two age groups accounted for 73.0% of all smokers. There was significant difference in smoking rate among different age groups (P<0.001). The smoking rate of those with a lower education level of primary school (57.9%) was the highest, and there were significant differences in smoking rates among the population with different education levels (P<0.001). The smoking rate of the solitary (95.7%) was higher than that of the non solitary (34.9%) (P<0.001). In 202 non-smokers, 67 (33.2%) was suffered from passive smoking, and the rate of passive smoking was 31.3% in males and 62.3% in females with a significant difference (P<0.001). The proportion of the female non-smokers against passive smoking (84.1%) was higher than that of the male non-smokers (57.8%). According to the participants report, 79.9% of participants approved completely non-smoking in hospital, school and public transport, 66.4% approved non-smoking in the office and traffic station, and only 10.2% approved non-smoking in the restaurants. Conclusions The rates of smoking and passive smoking among the population with the high risk of stroke are high, and most of the population are supportive to smoke prohibition in public places except restaurants. The population with a low cultural level is short of smoking harm knowledge.
目的 總結前交通動脈瘤栓塞治療的經驗。 方法 2008年1月－2011年8月，23例前交通動脈瘤患者均在全身麻醉下行動脈瘤內栓塞治療。其中4例在導絲或導管保護動脈瘤頸情況下行栓塞治療；1例術中導絲刺破動脈瘤，繼續快速填塞至動脈瘤完全栓塞；1例栓塞后彈簧圈突入載瘤動脈，行A1-A2段支架后置入。 結果 23例患者手術技術成功率100%。術后即刻造影，動脈瘤完全栓塞11例，＞90%栓塞8例，＜90%栓塞4例。支架后置入患者術后出現腦梗死，經治療1個月后康復出院。所有患者臨床隨訪6～24個月，未見再出血。16例患者行全腦血管數字減影血管成像復查，動脈瘤未見復發，其中3例＞90%栓塞、2例＜90%栓塞患者動脈瘤完全閉塞。 結論 彈簧圈栓塞治療前交通動脈瘤是一種安全、有效的治療方式。但其技術難度相對較大，需要細致操作。