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    find Author "DENG Lihui" 5 results
    • Clinical Characteristics and Treatment of Hyperthyroidism Liver Injury

      目的 總結甲狀腺功能亢進性肝功能損害 ( HLI ) 的臨床特點和治療方案。 方法 對2008年1月-2010年12月診治的49例HLI患者臨床資料進行回顧性總結分析,據其治療方案的不同分抗甲狀腺治療組和單純保肝治療組,比較二組患者治療后肝功能恢復情況。 結果 所有患者入院時均存在不明原因肝功能不全,而后明確為HLI。其中女29例(59.2%),男20例(40.8%),年齡10~70歲,平均45歲。 癥狀主要表現為體重下降(65.3%),心悸(51.1%),怕熱多汗(49.0%), 厭油納差、食欲減退 (44.9%)。主要體征包括甲狀腺腫大(36.7%),雙下肢水腫(24.5%),心界擴大(16.3%),皮膚鞏膜黃染(14.3%),肝脾腫大(12.2%)等。肝功能檢驗異常主要表現為谷丙轉氨酶升高(68.9%),谷草轉氨酶升高(57.8%)為主,其次是谷氨酰轉移酶(69.4%)、直接膽紅素(59.2%)、總膽紅素(44.9%)、堿性磷酸酶(42.9%)、乳酸脫氫酶(26.5%)升高,以及白蛋白(32.7%)下降。死亡3例,病死率6.1%。采用Wilcoxon秩和檢驗結果提示抗甲狀腺治療組的總膽紅素和直接膽紅素低于單純保肝治療組,組間差異有統計學意義(P<0.05)。 結論 此類患者可同時具備甲狀腺功能亢進和肝功能不全的臨床表現,肝功能常表現為淤膽型肝炎。HLI總體預后較好,抗甲狀腺治療是該病的關鍵。

      Release date:2016-09-08 09:13 Export PDF Favorites Scan
    • Research progress of growth differentiation factor 15 in digestive tumor

      Objective To have more insight into roles of growth differentiation factor-15 (GDF15) in digestive tumor. Method The basic and clinical studies on the GDF15 in the digestive tumors published were searched in the databases for summarizing the latest advances on this issue. Results The GDF15, a novel member of transforming growth factor-β superfamily, played the diverse roles in the progress of the various diseases. The increasing number of evidence indicated that the GDF15 was associated with the diagnosis and prognostication of the digestive tumors, eg: colorectal cancer, hepatocellular carcinoma, pancreatic adenocarcinoma, and might serve as a potential biomarker and therapeutic target for the multiple digestive tumors. Conclusions Current basic and clinical studies provide some evidences that GDF15 plays a role in digestive tumors. Further studies are needed to elucidate its roles and molecular mechanisms in different stages of diseases.

      Release date:2018-07-18 01:46 Export PDF Favorites Scan
    • Difficulties and prospects of combined traditional Chinese and Western medicine in the treatment of severe acute pancreatitis

      Despite of the progress in the treatment of severe acute pancreatitis (SAP), there are still factors that hinder the improvement of the efficacy of treatment: there is a lack of an accurate and easy-to-use system for early severity prediction; the multidisciplinary collaboration mechanism needs to be further optimized; there is no clinical efficacy evaluation system for traditional Chinese medicine (TCM); the therapeutic targets of TCM are unclear; the effector substances are unknown; and the research and development of new medicines is still difficult. In order to further reduce the mortality of SAP and realize the goal of improving the efficacy, we should strengthen the integration of Chinese and Western medicine, multidisciplinary collaboration, and improve the treatment levels; as well as carry out basic and clinical research oriented to clinical value. We will also promote the innovative development of combined Chinese and Western medicine in the treatment of SAP by elucidating the mechanism, validating the efficacy and commercializing the achievements. In view of SAP, a major and difficult disease, we should insist on the principle of integrity and innovation, the synergy of Chinese and Western medicines and the complementarity of advantages, and promote the innovation and development of combined Chinese and Western medicines in the treatment of SAP, so as to further reduce the morbidity and mortality and to alleviate the burden of the disease.

      Release date:2024-03-23 11:23 Export PDF Favorites Scan
    • Study on the value of blood glucose variability indexes in predicting persistent organ failure after acute pancreatitis

      ObjectiveTo explore the relationship between blood glucose variability index and persistent organ failure (POF) in acute pancreatitis (AP). MethodsWe prospectively included those patients who were diagnosed with AP with hyperglycemia and were hospitalized in the West China Center of Excellence for Pancreatitis of West China Hospital of Sichuan University from July 2019 to November 2021. The patients were given blood glucose monitoring at least 4 times a day for at least 3 consecutive days. The predictive value of blood glucose variability index for POF in patients with AP was analyzed. ResultsA total of 559 patients with AP were included, including 95 cases of POF. Comparing with those without POF, patients with AP complicated by POF had higher levels of admission glucose (11.0 mmol/L vs. 9.6 mmol/L), minimum blood glucose (6.8 mmol/L vs. 5.8 mmol/L), mean blood glucose (9.6 mmol/L vs. 8.7 mmol/L), and lower level of coefficient of variation of blood glucose (16.6 % vs. 19.0 %), P<0.05. Logistic regression analyses after adjustment for confounding factors showed that the risk of POF increased with the increase of admission glucose [OR=1.11, 95%CI (1.04, 1.19), P=0.002], minimum blood glucose [OR=1.28, 95%CI (1.10, 1.48), P=0.001] and mean blood glucose [OR=1.18, 95%CI (1.04, 1.33), P=0.010]; with the higher level of coefficient of variation of blood glucose [OR=0.95, 95%CI (0.92, 0.99), P=0.021], the risk of POF decreased. The results of area under the curve (AUC) of the receiver operator curves showed that AG [AUC=0.787, 95%CI (0.735, 0.840)] had the highest accuracy in predicting POF, with sensitivities of 60.0% and specificities of 84.7%. ConclusionHigh admission glucose, minimum blood glucose, mean blood glucose, and low coefficient of variation of blood glucose were risk factors for the development of POF in patients with hyperglycemic AP on admission.

      Release date:2024-03-23 11:23 Export PDF Favorites Scan
    • The clinical value of plasma microRNA-216 for early identifying the severity of acute pancreatitis

      ObjectiveTo investigate the value of plasma microRNA-216 (miR-216) in patients with acute pancreatitis as a clinical biomarker to early identify severe acute pancreatitis (SAP).MethodsPatients with acute pancreatitis who admitted to the hospital within 48 hours after the onset of disease between September and November 2014 were enrolled in this study. Plasam and clinical data of all the patients were collected. MiR-216 in the plasma was detected using quantitative real time-polymerase chain reaction.ResultsA total of 25 patients were enrolled. The Ct value of plasma miR-216 in SAP patients (32.40±1.43) was significantly upregulated than mild acute pancreatitis (MAP) (35.85±1.91, P<0.05) and moderately severe acute pancreatitis (MSAP) patients (35.90±2.44,P<0.05), respectively. The area under receiver operating characteristic curve for plasmamiR-216 in predicting SAP was 0.792 (P<0.05), which did not differ much from other conventional parameters such as C-reactive protein, urinary nitrogen, and cytokines (P>0.05).ConclusionPlasma miR-216 is significantly upregulated in SAP patients compared with MAP and MSAP, but it shows no inferior efficiency than the investigated conventional predictors in predicting SAP.

      Release date:2018-05-24 02:12 Export PDF Favorites Scan
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  • 松坂南