ObjectiveTo systematically review the infection and colonization of Mycoplasma genitalium (Mg) in the reproductive tract of pregnant females in China. MethodsPubMed, Web of Science, SinoMed, CNKI, VIP and WanFang Data databases were electronically searched to collect cross-sectional studies on Mg infection in pregnant females in China from inception to October 10, 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies; then, meta-analysis was performed by using R1.1.463 software. ResultsA total of 23 cross-sectional studies were included. The results of meta-analysis showed that the prevalence rate of Mg infection in pregnant females was 4.86% (95%CI 2.84% to 7.38%). The prevalence rates of Mg infection in females with ectopic pregnancy, spontaneous abortion, induced abortions and PROM were 13.01% (95%CI 6.90% to 20.69%), 11.81% (95%CI 3.30% to 24.59%), 6.11% (95%CI 2.70% to 10.77%), and 12.63% (95%CI 9.56% to 16.06%), respectively. ConclusionCurrent evidence shows that the prevalence rate of Mg infection in females with ectopic pregnancy, spontaneous abortion and premature rupture of membranes are higher than those in other pregnant females. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.
Objective To observe the effect of assisted reproductive technology (ART) on retinopathy of prematurity (ROP) in preterm infants. MethodsA retrospective clinical study. From January 2016 to January 2020, 639 preterm infants who were hospitalized at Children's Hospital of Zhengzhou University and underwent fundus screening at a gestational age ≤32 weeks were included in the study. There were 366 males and 273 females. Gestational age at birth were (28.3±1.4) weeks; birth weight were (1 153.8±228.8) g. Severe ROP was detected in 60 cases (9.4%, 60/639); 120 were ART recipients, and 519 were naturally conceived, and were divided into the ART group and the control group accordingly. The incidence of gestational diabetes mellitus (χ2=21.675), pulmonary surfactant application (χ2=13.558), and twin births (yes) (χ2=145.568) in mothers of the children examined in both groups were significantly higher than that of the control group, and the difference were statistically significant in all cases (P＜0.001). Comparison of quantitative data between groups was performed by t-test, and comparison of count data was performed by χ2 test; logistic regression was used to analyze the effect of ART on the incidence of ROP. ResultsOf the 60 cases of severe ROP, 18 (15.0%, 18/120) and 42 (8.1%, 42/519) cases were in the ART group and control group, respectively. The incidence of severe ROP was significantly higher in the ART group than in the control group, and the difference was statistically significant (χ2=4.680, P=0.024). Compared with the control group, the incidence of severe ROP was significantly higher in the ART group for gestational age at birth ＜28 weeks and birth weight ＜1 000 g, and the differences were statistically significant (χ2=10.116, 3.785; P=0.002, 0.037). Logistic regression analysis showed that ART was a non-independent risk factor for the occurrence of ROP (P＞0.05). ConclusionAssisted reproductive technology may have a certain influence on the occurrence of ROP, which is not an independent factor.
目的:評價氯喹那多普羅雌烯陰道片對產后陰道黏膜修復及防治生殖道感染的作用。方法:對212例產后6～8周復診患者隨機分為實驗組92例和對照組120例。實驗組給予氯喹那多普羅雌烯陰道片陰道上藥,每日一片共18日;對照組僅給予溫鹽水清潔陰部。治療前后檢查兩組的陰道分泌物情況。結果:用藥前實驗組與對照組比較生殖道狀況均無統計學差異(Pgt;005)。用藥后實驗組生殖道狀況正常為80%,而對照組正常僅為36%,兩組比較差異有顯著性(Plt;005)。實驗組生殖道感染12例,無真菌和滴蟲感染,均為非特異性陰道炎,患病率1304%,有效率8695%。對照組生殖道感染84例,有效率3000%,患病高低順序依次為非特異性陰道炎4167%,真菌性陰道炎2083%,滴蟲性陰道炎 750%。結論:氯喹那多普羅雌烯陰道片能有效治療生殖道非特異性炎癥,真菌性、滴蟲性陰道炎,促進產后的陰道黏膜修復,防治產后生殖道感染。
目的 探討泌尿生殖系統結核的臨床特點。 方法 對2006年5月－2011年5月住院確診為泌尿生殖系統結核的83例患者，總結分析其臨床特點、診療情況。 結果 患者病程平均3.2年，臨床特征多為尿路刺激癥狀、腎區疼痛及尿檢異常等，尿抗酸桿菌陽性率僅6.67%，診斷困難。器官功能受損重，手術比例高達44.58%。 結論 泌尿生殖系統結核雖發病率逐年下降，但臨床表現缺乏特異性，常延誤診斷治療。注重對該疾患臨床資料的全面收集和深入分析，對提高診療水平有重要意義。
目的：探討女性生殖道瘺的病因及預防措施。方法：回顧性分析我院婦產科2000年1月至2005年12月收治入院的57例女性生殖道瘺病例的病因。結果：產傷和婦科手術占女性生殖道瘺病因的前兩位，分別占56.1%（32/57）和33.3%（19/57）。結論：產傷和婦科手術是引起女性生殖道瘺的主要原因。加強圍產期保健、積極處理產科合并癥以及提高婦科手術技術是降低女性生殖道瘺發生率的關鍵因素。
Objective To evaluate the correlation between mycoplasma genitalium and HIV infection. Methods Databases including MEDLINE, ScienceDirect, EMbase, WanFang Data, and CNKI were searched from inception to March 2012, so as to identify the independent cohort studies, case-control studies and cross-sectional studies. Moreover, the references of relevant studies were also retrieved. According to the inclusion and exclusion criteria, the studies were screened, the data were extracted, and the methodological quality of the included studies was assessed. Then meta-analysis was performed using RevMan 4.2 and SAS 9.1.3 softwares. Results A total of 19 studies were included, including 3 430 HIV infected patients and 7 656 controlled participants. The results of meta-analyses showed that the HIV infection group was more likely to infect mycoplasma genitalium than the control group (OR=2.34, 95%CI 1.68 to 3.28, Plt;0.000 01). The same results were found in both subgroup and sensitivity analyses. Conclusion Mycoplasma genitaliuman infection is closely related to HIV infection. However, detailed pathogenesis is still unknown. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to prove the above.
目的 通過檢測人睪丸生殖細胞腫瘤中的Skp2蛋白質異常表達,探討相關意義。 方法 應用S-P免疫組織化學法檢測睪丸生殖細胞腫瘤，正常睪丸組織和慢性睪丸炎組織中Skp2的表達。 結果 睪丸生殖細胞腫瘤中Skp2陽性表達率為74.5%，正常睪丸組織中Skp2陽性表達率為20.0%，在慢性睪丸炎組織中Skp2陽性表達率為40.0%，在3種不同睪丸組織中表達差異有統計學意義（P＜0.05）；Skp2表達與不同組織學類型的睪丸生殖細胞腫瘤無相關性（P＞0.05）；隨著臨床分期的增高，睪丸生殖細胞腫瘤中的Skp2表達增多，差異無統計學意義（P＞0.05）。 結論 在人睪丸生殖細胞腫瘤中的Skp2高表達，提示細胞周期的異常調控在睪丸生殖細胞腫瘤的發生、分化中起著重要的作用。
【摘要】 目的 探討顱內原發生殖細胞瘤的臨床特征。方法 收集華西醫院腦外科2000年1月—2009年3月119例顱內原發生殖細胞瘤的臨床資料進行回顧性分析。結果 發病率約占同期顱內腫瘤的 1.1%。男〖DK〗∶女=1.64〖DK〗∶1,平均發病年齡15.4歲。臨床表現主要為顱內高壓癥狀及視力視野改變,分別為61、56例；腫瘤主要來源于松果體區及鞍區；64例患者行放療或放療加化療,隨訪45例。55例患者行手術治療(其中術后行單純放療19例,放療加化療5例),隨訪36例。隨訪時間3~94個月,平均29.7個月。行放療和放化療的患者3、5年生存率明顯高于單純行手術治療的患者。結論 顱內原發生殖細胞瘤多見于兒童及青少年,男性多見,腫瘤大多位于松果體區及鞍區。臨床表現位于松果體區者主要為顱內高壓癥狀等,位于鞍區者主要為視力視野改變、尿崩等。放療聯合化療是主要治療手段。