ObjectiveTo study the influence of psychological intervention on the immune function and psychological state in patients undergoing chemotherapy after radical operation of colorectal cancer. MethodSixty-four patients who underwent chemotherapy after eradicative resection of rectal cancer between August 2008 and August 2013 were randomly divided into control group and intervention group. Both the two groups of patients accepted conventional chemotherapy and nursing, while patients in the intervention group were also given psychological intervention. At the beginning of and 8 weeks after the therapy, self-evaluation of anxiety scale and depression self-rating scale were used to determine the psychological state (anxiety and depression) of patients in the two groups, and we evaluated the effect of psychological intervention. At the same time, the immune index and inflammatory cytokines were determined and compared between the two groups. ResultsBefore treatment, patients in both the two groups were accompanied by mild anxiety and depression. After psychological intervention, compared with the control group, anxiety and depression of patients in the intervention group were significantly alleviated (P<0.05). Before chemotherapy, patients in the two groups were not statistically different in the immune factor index (P>0.05). After chemotherapy, compared with the control group, natural killer cells, CD3+, CD4+, CD4+/CD8+, C-reactive protein, immunoglobulin (Ig) G, interleukin (IL)-10 level of the intervention group significantly increased (P<0.05), and IL-6 and tumor necrosis factor alpha expression decreased (P<0.05). CD8+, IgA and IgM were not significantly changed (P>0.05). ConclusionsPsychological intervention can alleviate anxiety and depression and improve the immune function in patients who undergo chemotherapy after radical operation of colorectal cancer, which is an effective auxiliary treatment.
【摘要】 目的 探討一次性麻醉穿刺包與普通腹腔穿刺包在腹腔化療中應用效果。 方法 將2008年6月-2009年4月住院的胃癌和卵巢癌行腹腔化療的患者53例，隨機分為兩組。實驗組29例，用一次性麻醉穿刺包行腹腔穿刺化療；對照組24例，用普通腹腔穿刺包行腹腔穿刺化療；比較兩組患者應用不同穿刺包行腹腔穿刺化療的并發癥比較。 結果 實驗組并發癥發生率明顯低于對照組(Plt;0.05)。 結論 一次性麻醉穿刺包應用于腹腔化療中操作簡便、創傷小、并發癥少，患者樂于接受等優點，值得在臨床上推廣使用。【Abstract】 Objective To explore the effects of one-off anesthesia paracentesis kit and ordinary peritoneal paracentesis kit in intraperitoneal chemotherapy. Methods A total of 53 patients with gastric cancer or ovarian cancer from June 2008 to April 2009 were randomly divided into two groups: 29 patients in trial group underwent intra-peritoneal chemotherapy with one-off anesthesia paracentesis kit, and 24 patients in the control group underwent intra-peritoneal chemotherapy with ordinary peritoneal paracentesis kit. The complications in two groups were compared. Results The incidence of complications in trial group was much lower than that in the control group (Plt;0.05). Conclusion One-off anesthesia paracentesis kit in intra-peritoneal chemotherapy has several advantages including simple manipulation, small injuries, and few complications, which is well accepted by the patients.
Objective To investigate the influence of self-care and self-efficacy intervention on the quality of life of patients undergoing chemotherapy after surgery for gastric cancer. Methods Sixty-four patients undergoing chemotherapy after gastric cancer surgery between July 2014 and February 2015 were selected as the study subjects. According the sequence of admission, they were divided into intervention group (n=34) and control group (n=30). Patients in the control group accepted conventional care, while those in the intervention group received self-efficacy and self-care interventions. The scores of General Self-efficacy Scale (GCES), Exercise of Self-care Agency (ESCA), and Quality of Life Instruments for Cancer Patients-Stomach Cancer (QLICP-ST) were compared between the two groups before and after intervention. Results After intervention, GCES scores of the intervention group and the control group were respectively (30.08±4.21) and (20.78±4.58) points; the total scores of ESCA were respectively (132.30±14.81) and (92.45±13.23) points; and the total scores of QLICP-ST were respectively (75.96±9.41) and (56.77±10.32) points. All the above differences between the two groups were significant (P<0.05). Conclusion Self-care and self-efficacy intervention can improve self-care ability and self-efficacy, and improve the quality of life of patients undergoing chemotherapy after gastric cancer surgery.