The Influence of Psychological Intervention on Immune Function and Psychological State in Patients Undergoing Chemotherapy after Radical Operation of Colorectal Cancer_West China Medical Journal

Authors：

 WANMin , WANGXiu-yun

Department of Abdominal Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

Keywords：

Psychological intervention; Cancer chemotherapy; Immune function; Psychological state

DOI：

10.7507/1002-0179.20150658

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Objective To study the influence of psychological intervention on the immune function and psychological state in patients undergoing chemotherapy after radical operation of colorectal cancer. Method Sixty-four patients who underwent chemotherapy after eradicative resection of rectal cancer between August 2008 and August 2013 were randomly divided into control group and intervention group. Both the two groups of patients accepted conventional chemotherapy and nursing, while patients in the intervention group were also given psychological intervention. At the beginning of and 8 weeks after the therapy, self-evaluation of anxiety scale and depression self-rating scale were used to determine the psychological state (anxiety and depression) of patients in the two groups, and we evaluated the effect of psychological intervention. At the same time, the immune index and inflammatory cytokines were determined and compared between the two groups. Results Before treatment, patients in both the two groups were accompanied by mild anxiety and depression. After psychological intervention, compared with the control group, anxiety and depression of patients in the intervention group were significantly alleviated (P<0.05). Before chemotherapy, patients in the two groups were not statistically different in the immune factor index (P>0.05). After chemotherapy, compared with the control group, natural killer cells, CD3⁺, CD4⁺, CD4⁺/CD8⁺, C-reactive protein, immunoglobulin (Ig) G, interleukin (IL)-10 level of the intervention group significantly increased (P<0.05), and IL-6 and tumor necrosis factor alpha expression decreased (P<0.05). CD8⁺, IgA and IgM were not significantly changed (P>0.05). Conclusions Psychological intervention can alleviate anxiety and depression and improve the immune function in patients who undergo chemotherapy after radical operation of colorectal cancer, which is an effective auxiliary treatment.

Citation： WANMin, WANGXiu-yun. The Influence of Psychological Intervention on Immune Function and Psychological State in Patients Undergoing Chemotherapy after Radical Operation of Colorectal Cancer. West China Medical Journal, 2015, 30(12): 2299-2302. doi: 10.7507/1002-0179.20150658 Copy

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10.	楊秀木, 馬語蓮, 陳永俠, 等. 綜合心理干預顯著改善圍術期老年乳腺癌患者的情緒和免疫功能[J]. 中國老年學雜志, 2013, 33(18):4399-4401.
11.	B?dvarsdóttir I, Elklit A. Psychological reactions in Icelandic earthquake survivors[J]. Scand J Psychol, 2004, 45(1):3-13.
12.	Maria K, Jane LH, Richard A. The relationship between acute stress disorder and posttraumatic stress disorder following cancer[J]. J Consult Clin Psychol, 2005, 73(2):360-364.
13.	Palesh O, Butler LD, Koopman C, et al. Stress history and breast cancer recurrence[J]. J Psychosom Res, 2007, 63(2):233-239.
14.	Duck HK, Traci M, Michael T, et al. Dose effects of relaxation practice on immune responses in women newly diagnosed with breast cancer:an exploratory study[J]. Oncol Nurs Forum, 2011, 38(3):240-253.

1. 黃英. 心理干預對腫瘤患者化療后免疫功能的影響[J]. 現代中西醫結合雜志, 2011, 20(35):4553-4554.
2. 趙蓓蓓, 周郁秋, 王玉玲, 等. 早期心理干預對車禍傷者負性情緒及免疫功能的影響[J]. 中華護理雜志, 2013, 48(10):920-923.
3. 焦安秀, 高偉, 楊敏, 等. 心理干預對腫瘤放療患者情緒及免疫功能的影響[J]. 齊魯護理雜志, 2009, 15(11):4-6.
4. 鄭華彬, 劉正湘. 心理干預對老年高血壓患者心理狀況與免疫功能的影響[J]. 高血壓雜志, 2003, 11(4):349-351.
5. 劉艷, 林文娟, 劉新帆, 等. 心理行為干預對乳腺癌患者情緒反應及免疫功能的影響[J]. 心理學報, 2001, 33(5):437-441.
6. 肖燦華, 王惠珍. 心理干預對乳腺癌患者情緒及免疫功能影響的研究進展(綜述)[J]. 中國心理衛生雜志, 2005, 19(10):691-693.
7. 林文娟, 王瑋雯, 邵楓, 等. 慢性情緒應激對大鼠行為、神經內分泌和免疫反應的影響:一個新的情緒應激模型[J]. 科學報, 2003, 48(9):926-929.
8. 邵楓, 林文娟. 情緒應激體液免疫調節作用的影響因素[J]. 心理學報, 2001, 33(6):543-547.
9. 李建中, 吳愛勤, 吳彩云, 等. 腫瘤患者的心理社會因素與免疫功能的測定[J]. 中國心理衛生雜志, 2002, 16(6):386-389.
10. 楊秀木, 馬語蓮, 陳永俠, 等. 綜合心理干預顯著改善圍術期老年乳腺癌患者的情緒和免疫功能[J]. 中國老年學雜志, 2013, 33(18):4399-4401.
11. B?dvarsdóttir I, Elklit A. Psychological reactions in Icelandic earthquake survivors[J]. Scand J Psychol, 2004, 45(1):3-13.
12. Maria K, Jane LH, Richard A. The relationship between acute stress disorder and posttraumatic stress disorder following cancer[J]. J Consult Clin Psychol, 2005, 73(2):360-364.
13. Palesh O, Butler LD, Koopman C, et al. Stress history and breast cancer recurrence[J]. J Psychosom Res, 2007, 63(2):233-239.
14. Duck HK, Traci M, Michael T, et al. Dose effects of relaxation practice on immune responses in women newly diagnosed with breast cancer:an exploratory study[J]. Oncol Nurs Forum, 2011, 38(3):240-253.

West China Medical Journal

The Influence of Psychological Intervention on Immune Function and Psychological State in Patients Undergoing Chemotherapy after Radical Operation of Colorectal Cancer

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