ObjectiveTo review the research progress of three-dimensional (3D) bioprinting technology for wound dressing design and preparation. Methods The literature on 3D bioprinted wound dressings in recent years, both domestically and internationally, was retrieved. The core principles of 3D bioprinting technology, mainstream methods, and their applications in wound dressings design and preparation were summarized. Results By leveraging precise spatial manipulation capabilities and multi-material integration, 3D bioprinting technology constructs the functionalized wound dressings with complex structures and bioactivity. These dressings primarily function across several dimensions: wound hemostasis, infection control, controlled drug release, and monitoring wound healing. Conclusion Although 3D bioprinted wound dressings can promote wound healing through multiple dimensions, large-scale clinical validation is still lacking. Future efforts should further clarify their clinical value and scope of application to provide more efficient, precise, and patient-comfortable treatment options for refractory wounds.
目的 為老年股骨頸骨折的患者制定合理的循證護理方案。 方法 在充分了解老年股骨頸患者病情的基礎上，根據PICO原則，提出臨床問題并轉化為易于檢索的形式，于2012年5月檢索了Cochrane系統評價數據庫（CDSR）、Cochrane對照試驗注冊中心（CCTR）、效果評論摘要數據庫（DARE）、Medline、國家指南網（NGC）、PubMed 網站、中國生物醫學文獻數據庫（CBM）以及復旦大學JBI循證護理中心，獲取并評價相關的系統評價、隨機對照試驗以及臨床指南。 結果 共檢索到3篇系統評價、2篇臨床隨機對照試驗和1篇臨床實踐指南。根據檢索的結果，與患者及家屬溝通后，選用Braden量表對患者進行壓瘡評估；指導患者每2小時翻身；進行腰背肌的鍛煉，2～4 h/次，第1天5遍/次，之后逐漸遞增為10～20遍/次；指導攝入高能量、高蛋白食物。1周后，患者機體狀況良好，順利接受手術治療。 結論 采取循證護理的方法可以為患者提供科學、個性化的護理。
Objective To explore the burden situation among caregivers of stroke survivors, and analyze the association between burden and the quality of life among caregivers. Method In this cross-sectional study, a total of 230 stroke survivor-caregivers were investigated with basic demographic information, Zarit Burden Interview (ZBI) and the World Health Organization Quality of Life Instrument-Short Form (WHOQOL-BREF) from May 2015 to November 2015. Results The mean age of the caregivers of stroke survivors was (66.7±11.7) years, and the caregiver burden was in the mild level with the mean ZBI score of 21.11±6.96. The multiple linear regression analysis showed that the influencing factors of caregiver burden were the complications, self-care ability, residence of stroke survivors, and the self-rating health status of caregivers (P<0.05). And the total ZBI score was negatively correlated with the total WHOQOL-BREF scores (P<0.01), physiological dimensional scores (P<0.01), social dimensional scores (P<0.01), and environmental dimensional scores of caregivers (P<0.01). Conclusions The caregivers of stroke survivors suffer from general caregiver burden, and the heavier caregiver burden is, the poorer the quality of life of the caregivers is. According to the different conditions between urban and rural areas of China, it is reasonable to formulate a targeted program with the consideration of requirements referring to stroke survivors and their caregivers. It should involve physiological, psychological, social, environmental factors and so on to improve the caregivers’ quality of life finally.
目的 探討結腸癌患者術后3年生存情況的影響因素。方法 回顧2006年1月至2007年12月期間筆者所在科室收治的確診為結腸癌且隨訪資料完整的169例患者臨床資料，從術前CEA水平、腫瘤病理分型、分化程度和體質指數（BMI）方面分析影響結腸癌預后的因素。結果 術前CEA水平、腫瘤分化程度及BMI對術后3年生存期的差異有統計學意義（P＜0.05），術前CEA水平對術后3年生存率的差異均有統計學意義（P＜0.05）；術前CEA水平、病理分型、分化程度對術后發生轉移的差異有統計學意義（P＜0.05）。結論 術前CEA水平是結腸癌預后的高危因素。
ObjectiveTo analyze the risk factors of acute wound infection in orthopedic patients. MethodsA retrospective analysis was made on the clinical data of 576 orthopedic patients in accordance with the inclusion criteria between July and October 2012. There were 345 males and 231 females, aged 18-95 years (mean, 44 years). Single factor analysis was used for related factors, and logistic regression analysis of multi-factors for risk factors of acute wound infection. ResultsWound infection occurred in 73 of 576 patients (12.7%). Single factor analysis showed that the influence factors were gender, education, smoking history, nutritional status (hemoglobin, red blood cell count, serum albumin, and total serum protein), blood glucose level, shock history, wound situation (characteristics, multiple injuries, and cleaning), type of injuries, the time of trauma handling, antibiotic use, whether to stay in ICU, wound pain score, drug analgesia, patient controlled analgesia, and dressings and cleaning solution choice. The logistic regression analysis showed that the gender, time of trauma handling, blood glucose level, wound pain score, dressing choice, and wound characteristics were the risk factors of acute wound infection (P<0.05). ConclusionTo achieve the best results in clinical prevention of infection, these risk factors (gender, the time of trauma handling, blood glucose level, wound pain score, dressing choice, and wound characteristics) should be considered well.