余葉蓉,
Email: yerongyu@scu.edu.cn
內分泌激素和神經系統一起調節著機體的各種生命活動,癲癇和內分泌激素有著密切而復雜的關聯,癲癇的發作可能影響體內激素水平,反之,體內激素水平的變化尤其是神經類固醇激素可影響癲癇的發作頻率和嚴重程度,激素還可以間接通過藥物代謝動力作用改變抗癲癇藥物(AEDs)的濃度從而對癲癇產生影響。癲癇與內分泌激素之間關系復雜,給臨床治療帶來一定的挑戰。目前隨著人們對于下丘腦-垂體-腎上腺(Hypothalamus pituitary adrenal, HPA)軸、下丘腦-垂體-甲狀腺((Hypothalamic pituitary thyroid axis, HPT)軸及下丘腦-垂體-性腺(卵巢/睪丸)(Hypothalamo pituitary ovarian, HPO)軸在癲癇中的表現和作用研究的逐漸深入,給臨床治療和控制癲癇帶來一絲曙光。如何發現癲癇患者發作規律,揭示誘發癲癇和內分泌紊亂的病因機制和危險因素,對早期進行干預和指導醫師臨床診療具有重大的臨床意義,對于癲癇患者生活質量的提高也有所裨益。現圍繞癲癇與內分泌激素的相互作用和相關研究進展進行分析闡述。
Citation： 譚惠文, 余葉蓉. 癲癇與內分泌激素關系的研究進展. Journal of Epilepsy, 2016, 2(6): 509-514. doi: 10.7507/2096-0247.20160090 Copy
Copyright ? the editorial department of Journal of Epilepsy of West China Medical Publisher. All rights reserved
| 1. | Pack M, Reddy DS, Duncan S,et al. Neuroendocrinological aspects of epilepsy:important issues and trends in future research. Epilepsy Behav, 2011, 22(7):94-102. |
| 2. | Reddy DS. Role of hormones and neurosteroids in eplileptogenesis. Front Cell Neurosci, 2013, 7(3):115. |
| 3. | Biagini G,Panuccio G, Avoli M. Neruosteroids and epilepsy. Curr Opin Neurol, 2010, 23(2):170-176. |
| 4. | Svalheim S, Sveberg L, Mochol M,et al.Interactions between antiepileptic drugs and hormones. Seizure, 2015, 28(2):12-17. |
| 5. | Luef G.Hormonal alterations following seizures. Epilepsy Behav, 2010, 19(2):131-133. |
| 6. | Maguire J, Salpekar JA. Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy.Epilepsy Behav, 2013,26(3):352-362. |
| 7. | Wulsin AC, Solomon MB, Privitera MD,et al.Hypothalamic-pituitary-adrenocortical axis dysfunction in epilepsy.Physiol Behav, 2016,166(1):22-31. |
| 8. | Joshi S, Rajasekaran K, Kapur J.GABAergic transmission in temporal lobe epilepsy:the role of neurosteroids.Exp Neurol, 2013, 244(2):36-42. |
| 9. | Danzer SC.Depression, stress, epilepsy and adult neurogenesis.Exp Neurol, 2012, 233(1):22-32. |
| 10. | van Campen JS, Valentijn FA, Jansen FE. Seizure occurrence and the circadian rhythm of cortisol:a systematic review.Epilepsy Behav, 2015, 47(3):132-137. |
| 11. | Badawy RA, Freestone DR, Lai A. Epilepsy:Ever-changing states of cortical excitability.Neuroscience, 2012, 222(11):89-99. |
| 12. | 胡琳, 張華丹,陳亞天,等. 不同藥物誘導的小鼠癲癇模型的差異性研究.浙江大學學報(醫學版), 2013, 42(6):609-610. |
| 13. | Jones NC.Potentiating the strength of extrasynaptic currents by neurosteroid hormones.Epilepsy Curr, 2016, 16(4):261-262. |
| 14. | De Leon J.The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part I:A summary of the current state for clinicians.Rev Psiquiatr Salud Ment, 2015, 8(2):97-115. |
| 15. | Bernal J. Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab, 2007, 3(1):249-259. |
| 16. | Hamed SA.The effect of antiepileptic drugs on thyroid hormonal function:causes and implications. Expert Rev Clin Pharmacol, 2015, 8(6):741-750. |
| 17. | Kaya M, Becker AJ, Gürses C.Blood-brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia.Epilepsia, 2012, 53(Suppl 6):31-36. |
| 18. | Hamed SA, Hamed EA, Kandil MR.Serum thyroid hormone balance and lipid profile in patients with epilepsy.Epilepsy Res, 2005,66(1-3):173-183. |
| 19. | Mehran L, Amouzegar A, Tohidi M.Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects. Thyroid, 2014, 24(11):1566-1574. |
| 20. | El-Khayat HA, Aly GS, Tomoum HY, et al.Growth hormone levels in children and adolescents with epilepsy.Eur J Paediatr Neurolm, 2010, 14(6):508-512. |
| 21. | Devinsky O, Emoto S, Goldstein DS, et al. Cerebrospinal fluid and serum levels of dopa, catechols, and monoamine metabolites in patients with epilepsy.Epilepsia, 1992, 33(2):263-270. |
| 22. | Martinez A, Finegersh A, Cannon DM.The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy. Neurology, 2013, 80(16):1465-1471. |
| 23. | Kurian MA, Gissen P, Smith M.The monoamine neurotransmitter disorders:an expanding range of neurological syndromes.Lancet Neurol, 2011, 10(8):721-733. |
| 24. | Recio MV, Gallagher MJ, McLean MJ. Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center.Epilepsy Res, 2007, 76(1):1-5. |
| 25. | Scharfman HE. The neurobiology of epilepsy.Curr Neurol Neurosci Rep, 2007, 7(4):348-354. |
| 26. | Bauer J.Epilepsy and prolactin in adults:a clinical review.Epilepsy Res, 1996, 24(1):1-7. |
| 27. | Luef G, Madersbacher H.Sexual dysfunction in patients with epilepsy. Handb Clin Neurol, 2015, 130(2):383-394. |
| 28. | Schmidt D, Schachter SC. Drug treatment of epilepsy in adults.BMJ, 2014, 348(28):254. |
| 29. | Sundararajan T, Tesar GE, Jimenez XF.Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures:a systematic review.Seizure, 2016, 35(3):11-22. |
| 30. | Du Y, Kemper T, Qiu J, Jiang J. Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus. Expert Rev Neurother, 2016,16(2):123-130. |
| 31. | Onaka T, Takayanagi Y, Leng G. Metabolic and stress-related roles of prolactin-releasing peptide. Trends Endocrinol Meta, 2010, 21(5):287-293. |
| 32. | Trimble MR. Serum prolactin in epilepsy and hysteria. Br Med J, 1978, 2(6153):1682. |
| 33. | Kanasaki H, Oride A, Mijiddorj T.Role of thyrotropin-releasing hormone in prolactin-producing cell models.Neuropeptides, 2015, 54(1):73-77. |
| 34. | 陳柳靜, 周列民,周玨倩,等. 育齡女性癲癇患者的生殖內分泌紊亂相關危險因素分析. 中山大學學報(醫學科學版), 2010, 31(2):302-305. |
| 35. | Maguire J, Salpekar JA.Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy.Epilepsy Behav, 2013, 26(3):352-362. |
| 36. | Frye CA. Hormonal influences on seizures:basic neurobiology.Int Rev Neurobiol, 2008, 83(3):27-77. |
| 37. | Mehta V, Ferrie CD, Cross JH. Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms. Cochrane Database Syst Rev, 2015, 15(6):CD005222. |
| 38. | Xiong F, Zhang L. Role of the hypothalamic-pituitary-adrenal axis in developmental programming of health and disease.Front Neuroendocrinol, 2013,34(1):27-46. |
| 39. | Fekete C, Lechan RM.Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.Endocr Rev, 2014, 35(2):159-194. |
| 40. | Woodbury DM, Hurley RE.Effect of thyroxin, thyroidectomy and 6-n-propyl-2-thiouracil on brain function. J Pharmacol Exp Ther, 1952, 106(3):331-340. |
| 41. | Jabbari B, Huott AD.Seizures in thyrotoxicosis. Epilepsia, 1980, 21(1):91-96. |
| 42. | Taub?ll E, Sveberg L, Svalheim S.Interactions between hormones and epilepsy.Seizure, 2015, 28(5):3-11. |
| 43. | Jeurissen B, Leemans A, Tournier JD, et al. Investigating theprevalence of complex fiber configurations in white matter tissue withdiffusion magnetic resonance imaging. Hum Brain Mapp, 2013, 34(5):2747-2766. |
| 44. | Shultz SR, Zheng P, Wright DK, et al. Tractography and magneticresonance spectroscopy in acquired epilepsy models. WONOEP XⅡmeeting planner, 2013, QC, Canada. |
| 45. | Jones DK, Knosche TR, Turner R. White matter integrity, fiber count,and other fallacies:the do's and dont's of diffusion MRI. Neuroimage, 2013, 73(12):239-254. |
| 46. | Ogawa S, Lee TM, Nayak AS, et al. Oxygenation-sensitive contrast inmagnetic resonance image of rodent brain at high magnetic fields.Magn Reson Med, 1990, 14(7):68-78. |
| 47. | Smith G, Wagner JL, Edwards JC. Epilepsy Update, Part 1:refining our understanding of a complex disease.Am J Nurs, 2015, 115(5):40-47. |
| 48. | Galimberti CA, Magri F, Copello F. Changes in sex steroid levels in women with epilepsy on treatment:relationship with antiepileptic therapies and seizure frequency. Epilepsia, 2009,50 (Suppl 1):28-32. |
| 49. | Herzog AG.Menstrual disorders in women with epilepsy.Neurology, 2006, 66(Suppl 3):23-28. |
| 50. | van Luijtelaar G, Onat FY, Gallagher MJ.Animal models of absence epilepsies:what do they model and do sex and sex hormones matter?. Neurobiol Dis, 2014,72(Pt B):167-179. |
| 51. | Chiu AW, Daniel S, Khosravani H.Prediction of seizure onset in an in-vitro hippocampal slice model of epilepsy using Gaussian-based and wavelet-based artificial neural networks.Ann Biomed Eng, 2005,33(6):798-810. |
| 52. | Mejías-Aponte CA, Jiménez-Rivera CA, Segarra AC.Sex differences in models of temporal lobe epilepsy:role of testosterone.Brain Res, 2002,944(1-2):210-218. |
| 53. | Bauer J, Blumenthal S, Reuber M.Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy.Neurology, 2004,62(2):243-246. |
| 54. | Herzog AG, Fowler KM.Sexual hormones and epilepsy:threat and opportunities.Curr Opin Neurol, 2005, 18(2):167-172. |
| 55. | Hamed SA.Neuroendocrine hormonal conditions in epilepsy:relationship to reproductive and sexual functions. Neurologist, 2008, 14(3):157-169. |
| 56. | R, Wainwright SR, Galea LA.Sex hormones and adult hippocampal neurogenesis:Regulation, implications, and potential mechanisms.Front Neuroendocrinol. 2016,41:129-52. |
| 57. | Alam MN, Ahmad A, Al-Abbasi FA, Ahmad A.Female ovarian steroids in epilepsy:a cause or remedy.Pharmacol Rep, 2013,65(4):802-12. |
| 58. | Herzog AG.Catamenial epilepsy:Update on prevalence, pathophysiology and treatment from the findings of the NIH progesterone treatment trial. Seizure, 2015, 28(5):18-25. |
- 1. Pack M, Reddy DS, Duncan S,et al. Neuroendocrinological aspects of epilepsy:important issues and trends in future research. Epilepsy Behav, 2011, 22(7):94-102.
- 2. Reddy DS. Role of hormones and neurosteroids in eplileptogenesis. Front Cell Neurosci, 2013, 7(3):115.
- 3. Biagini G,Panuccio G, Avoli M. Neruosteroids and epilepsy. Curr Opin Neurol, 2010, 23(2):170-176.
- 4. Svalheim S, Sveberg L, Mochol M,et al.Interactions between antiepileptic drugs and hormones. Seizure, 2015, 28(2):12-17.
- 5. Luef G.Hormonal alterations following seizures. Epilepsy Behav, 2010, 19(2):131-133.
- 6. Maguire J, Salpekar JA. Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy.Epilepsy Behav, 2013,26(3):352-362.
- 7. Wulsin AC, Solomon MB, Privitera MD,et al.Hypothalamic-pituitary-adrenocortical axis dysfunction in epilepsy.Physiol Behav, 2016,166(1):22-31.
- 8. Joshi S, Rajasekaran K, Kapur J.GABAergic transmission in temporal lobe epilepsy:the role of neurosteroids.Exp Neurol, 2013, 244(2):36-42.
- 9. Danzer SC.Depression, stress, epilepsy and adult neurogenesis.Exp Neurol, 2012, 233(1):22-32.
- 10. van Campen JS, Valentijn FA, Jansen FE. Seizure occurrence and the circadian rhythm of cortisol:a systematic review.Epilepsy Behav, 2015, 47(3):132-137.
- 11. Badawy RA, Freestone DR, Lai A. Epilepsy:Ever-changing states of cortical excitability.Neuroscience, 2012, 222(11):89-99.
- 12. 胡琳, 張華丹,陳亞天,等. 不同藥物誘導的小鼠癲癇模型的差異性研究.浙江大學學報(醫學版), 2013, 42(6):609-610.
- 13. Jones NC.Potentiating the strength of extrasynaptic currents by neurosteroid hormones.Epilepsy Curr, 2016, 16(4):261-262.
- 14. De Leon J.The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part I:A summary of the current state for clinicians.Rev Psiquiatr Salud Ment, 2015, 8(2):97-115.
- 15. Bernal J. Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab, 2007, 3(1):249-259.
- 16. Hamed SA.The effect of antiepileptic drugs on thyroid hormonal function:causes and implications. Expert Rev Clin Pharmacol, 2015, 8(6):741-750.
- 17. Kaya M, Becker AJ, Gürses C.Blood-brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia.Epilepsia, 2012, 53(Suppl 6):31-36.
- 18. Hamed SA, Hamed EA, Kandil MR.Serum thyroid hormone balance and lipid profile in patients with epilepsy.Epilepsy Res, 2005,66(1-3):173-183.
- 19. Mehran L, Amouzegar A, Tohidi M.Serum free thyroxine concentration is associated with metabolic syndrome in euthyroid subjects. Thyroid, 2014, 24(11):1566-1574.
- 20. El-Khayat HA, Aly GS, Tomoum HY, et al.Growth hormone levels in children and adolescents with epilepsy.Eur J Paediatr Neurolm, 2010, 14(6):508-512.
- 21. Devinsky O, Emoto S, Goldstein DS, et al. Cerebrospinal fluid and serum levels of dopa, catechols, and monoamine metabolites in patients with epilepsy.Epilepsia, 1992, 33(2):263-270.
- 22. Martinez A, Finegersh A, Cannon DM.The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy. Neurology, 2013, 80(16):1465-1471.
- 23. Kurian MA, Gissen P, Smith M.The monoamine neurotransmitter disorders:an expanding range of neurological syndromes.Lancet Neurol, 2011, 10(8):721-733.
- 24. Recio MV, Gallagher MJ, McLean MJ. Clinical features of epilepsy in patients with cerebellar structural abnormalities in a referral center.Epilepsy Res, 2007, 76(1):1-5.
- 25. Scharfman HE. The neurobiology of epilepsy.Curr Neurol Neurosci Rep, 2007, 7(4):348-354.
- 26. Bauer J.Epilepsy and prolactin in adults:a clinical review.Epilepsy Res, 1996, 24(1):1-7.
- 27. Luef G, Madersbacher H.Sexual dysfunction in patients with epilepsy. Handb Clin Neurol, 2015, 130(2):383-394.
- 28. Schmidt D, Schachter SC. Drug treatment of epilepsy in adults.BMJ, 2014, 348(28):254.
- 29. Sundararajan T, Tesar GE, Jimenez XF.Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures:a systematic review.Seizure, 2016, 35(3):11-22.
- 30. Du Y, Kemper T, Qiu J, Jiang J. Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus. Expert Rev Neurother, 2016,16(2):123-130.
- 31. Onaka T, Takayanagi Y, Leng G. Metabolic and stress-related roles of prolactin-releasing peptide. Trends Endocrinol Meta, 2010, 21(5):287-293.
- 32. Trimble MR. Serum prolactin in epilepsy and hysteria. Br Med J, 1978, 2(6153):1682.
- 33. Kanasaki H, Oride A, Mijiddorj T.Role of thyrotropin-releasing hormone in prolactin-producing cell models.Neuropeptides, 2015, 54(1):73-77.
- 34. 陳柳靜, 周列民,周玨倩,等. 育齡女性癲癇患者的生殖內分泌紊亂相關危險因素分析. 中山大學學報(醫學科學版), 2010, 31(2):302-305.
- 35. Maguire J, Salpekar JA.Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy.Epilepsy Behav, 2013, 26(3):352-362.
- 36. Frye CA. Hormonal influences on seizures:basic neurobiology.Int Rev Neurobiol, 2008, 83(3):27-77.
- 37. Mehta V, Ferrie CD, Cross JH. Corticosteroids including ACTH for childhood epilepsy other than epileptic spasms. Cochrane Database Syst Rev, 2015, 15(6):CD005222.
- 38. Xiong F, Zhang L. Role of the hypothalamic-pituitary-adrenal axis in developmental programming of health and disease.Front Neuroendocrinol, 2013,34(1):27-46.
- 39. Fekete C, Lechan RM.Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.Endocr Rev, 2014, 35(2):159-194.
- 40. Woodbury DM, Hurley RE.Effect of thyroxin, thyroidectomy and 6-n-propyl-2-thiouracil on brain function. J Pharmacol Exp Ther, 1952, 106(3):331-340.
- 41. Jabbari B, Huott AD.Seizures in thyrotoxicosis. Epilepsia, 1980, 21(1):91-96.
- 42. Taub?ll E, Sveberg L, Svalheim S.Interactions between hormones and epilepsy.Seizure, 2015, 28(5):3-11.
- 43. Jeurissen B, Leemans A, Tournier JD, et al. Investigating theprevalence of complex fiber configurations in white matter tissue withdiffusion magnetic resonance imaging. Hum Brain Mapp, 2013, 34(5):2747-2766.
- 44. Shultz SR, Zheng P, Wright DK, et al. Tractography and magneticresonance spectroscopy in acquired epilepsy models. WONOEP XⅡmeeting planner, 2013, QC, Canada.
- 45. Jones DK, Knosche TR, Turner R. White matter integrity, fiber count,and other fallacies:the do's and dont's of diffusion MRI. Neuroimage, 2013, 73(12):239-254.
- 46. Ogawa S, Lee TM, Nayak AS, et al. Oxygenation-sensitive contrast inmagnetic resonance image of rodent brain at high magnetic fields.Magn Reson Med, 1990, 14(7):68-78.
- 47. Smith G, Wagner JL, Edwards JC. Epilepsy Update, Part 1:refining our understanding of a complex disease.Am J Nurs, 2015, 115(5):40-47.
- 48. Galimberti CA, Magri F, Copello F. Changes in sex steroid levels in women with epilepsy on treatment:relationship with antiepileptic therapies and seizure frequency. Epilepsia, 2009,50 (Suppl 1):28-32.
- 49. Herzog AG.Menstrual disorders in women with epilepsy.Neurology, 2006, 66(Suppl 3):23-28.
- 50. van Luijtelaar G, Onat FY, Gallagher MJ.Animal models of absence epilepsies:what do they model and do sex and sex hormones matter?. Neurobiol Dis, 2014,72(Pt B):167-179.
- 51. Chiu AW, Daniel S, Khosravani H.Prediction of seizure onset in an in-vitro hippocampal slice model of epilepsy using Gaussian-based and wavelet-based artificial neural networks.Ann Biomed Eng, 2005,33(6):798-810.
- 52. Mejías-Aponte CA, Jiménez-Rivera CA, Segarra AC.Sex differences in models of temporal lobe epilepsy:role of testosterone.Brain Res, 2002,944(1-2):210-218.
- 53. Bauer J, Blumenthal S, Reuber M.Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy.Neurology, 2004,62(2):243-246.
- 54. Herzog AG, Fowler KM.Sexual hormones and epilepsy:threat and opportunities.Curr Opin Neurol, 2005, 18(2):167-172.
- 55. Hamed SA.Neuroendocrine hormonal conditions in epilepsy:relationship to reproductive and sexual functions. Neurologist, 2008, 14(3):157-169.
- 56. R, Wainwright SR, Galea LA.Sex hormones and adult hippocampal neurogenesis:Regulation, implications, and potential mechanisms.Front Neuroendocrinol. 2016,41:129-52.
- 57. Alam MN, Ahmad A, Al-Abbasi FA, Ahmad A.Female ovarian steroids in epilepsy:a cause or remedy.Pharmacol Rep, 2013,65(4):802-12.
- 58. Herzog AG.Catamenial epilepsy:Update on prevalence, pathophysiology and treatment from the findings of the NIH progesterone treatment trial. Seizure, 2015, 28(5):18-25.