Causes and countermeasures of waste in clinical research of Chinese medicine_Chinese Journal of Evidence-Based Medicine

Authors：

YANG Fengwen , JI Zhaochen , ZHANG Mingyan , PANG Wentai , WANG Hucheng , ZHENG Wenke ,  ZHANG Junhua

Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P.R.China;

Corresponding?author：

ZHANG Junhua, Email: zjhtcm@foxmail.com

Keywords：

Research waste; Traditional Chinese medicine; REWARD

DOI：

10.7507/1672-2531.201807109

Video：

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The issue of waste in medical research has been widely concerned in recent years. Research waste is also significant in the field of traditional Chinese medicine (TCM). This study summarized the causes of research waste in TCM and provided suggestions to researchers and administrators for reducing research waste and promoting rational use of medical research resources.

Citation： YANG Fengwen, JI Zhaochen, ZHANG Mingyan, PANG Wentai, WANG Hucheng, ZHENG Wenke, ZHANG Junhua. Causes and countermeasures of waste in clinical research of Chinese medicine. Chinese Journal of Evidence-Based Medicine, 2018, 18(11): 1212-1215. doi: 10.7507/1672-2531.201807109 Copy

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2.	Chalmers I, Bracken MB, Djulbegovic B, et al. How to increase value and reduce waste when research priorities are set. Lancet, 2014, 383(9912): 156-165.
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13.	常靜, 李廷謙, 萬美華, 等. 中國4種中醫藥大學學報隨機對照臨床試驗文獻的質量評價. 中國循證醫學雜志, 2006, 6(3): 171-178.
14.	張明妍, 楊豐文, 李越, 等. 《中國中西醫結合雜志》刊載中醫藥隨機對照試驗報告質量的研究. 中國循證醫學雜志, 2017, 17(3): 357-363.
15.	Gargon E, Gurung B, Medley N, et al. Choosing important health outcomes for comparative effectiveness research: a systematic review. PLoS One, 2014, 9(6): e99111.
16.	張明妍, 張俊華, 張伯禮. 2015年中藥治療穩定性心絞痛臨床試驗結局指標文獻研究. 中國中西醫結合雜志, 2018, 38(2): 191-197.
17.	Taichman DB, Sahni P, Pinborg A, et al. Data sharing statements for clinical trials. BMJ, 2017, 357(23): 2372.
18.	吳泰相, 米娜瓦爾·阿不都, 郝園, 等. 中國臨床試驗注冊10年: 現狀與問題. 中國循證醫學雜志, 2018, 18(6): 522-525.
19.	Xing DM, Sun Y, Zhu MJ, et al. The status of IRBs/ECs, ICFs and trial registration in clinical trials of traditional Chinese medicine for stable angina. Int J Cardiol, 2014, 174(2): 396-397.
20.	吳泰相, 卞兆祥, 李幼平, 等. 臨床試驗原始數據透明化與共享:關于醫學研究倫理的哲學命題及其對臨床試驗的意義. 中國循證醫學雜志, 2018, 18(6): 538-542.
21.	陳耀龍, 周奇, 崔榮榮, 等. 基于AGREE Ⅱ的中醫藥臨床指南質量評價. 中國循證醫學雜志, 2016, 16(11): 1331-1337.
22.	ClinicalTrials. gov. Available at: http: //www. clinicaltrials. gov/.
23.	中國臨床試驗注冊中心. Available at: http: //www. chictr. org. cn/index. aspx.
24.	鄭文科. 發揮中醫藥優勢, 應對感染性疾病挑戰--第二屆循證中醫藥學國際論壇成功舉行. 天津中醫藥, 2017, 34(5): 289-290.
25.	邢冬梅, 張俊華, 張伯禮. 中醫臨床研究核心結局指標集形成路徑. 中華中醫藥雜志, 2014, 29(5): 1352-1355.
26.	COMET Initiative. Available at: http://www.comet-initiative.org/.
27.	張伯禮: 以核心指標集研究為切入點推動中醫藥臨床研究質量提升. Available at: http://www.xinhuanet.com/health/2018-01/31/c_1122347918.htm.
28.	Kirkham JJ, Gorst S, Altman DG, et al. COS-STAR: a reporting guideline for studies developing core outcome sets (protocol). Trials, 2015, 16(1): 373.
29.	中醫藥臨床證據數據庫. Available at: http://www.adrade.cn/evidence/index.
30.	發揮中醫藥優勢應對感染性疾病挑戰. Available at: http://news.xinhuanet.com/health/2017-04/25/c_1120868927.htm.

1. Chalmers I, Glasziou P. Avoidable waste in the production and reporting of research evidence. Lancet, 2009, 374(9692): 1341-1345.
2. Chalmers I, Bracken MB, Djulbegovic B, et al. How to increase value and reduce waste when research priorities are set. Lancet, 2014, 383(9912): 156-165.
3. Ioannidis JP, Greenland S, Hlatky MA, et al. Increasing value and reducing waste in research design, conduct, and analysis. Lancet, 2014, 383(9912): 166.
4. Salman AS, Beller E, Kagan J, et al. Increasing value and reducing waste in biomedical research regulation and management. Lancet, 2014, 383(9912): 176-185.
5. Chan AW, Song F, Vickers A, et al. Increasing value and reducing waste: addressing inaccessible research. Lancet, 2014, 383(9913): 257.
6. Glasziou P, Altman DG, Bossuyt P, et al. Reducing waste from incomplete or unusable reports of biomedical research. Lancet, 2014, 383(9913): 267.
7. THE LANCET. Available at: https://www.thelancet.com/campaigns/efficiency/statement.
8. 張俊華, 李幼平, 張伯禮. 循證中醫藥學: 理論與實踐. 中國中藥雜志, 2018, 43(1): 1-7.
9. 王家瑩, 田貴華, 張莉, 等. 中醫藥系統評價/Meta分析結果的引證現狀調查. 蘭州大學學報(醫學版), 2016, 42(1): 48-54.
10. Lund H, Brunnhuber K, Juhl C, et al. Towards evidence based research. BMJ, 2016, 355: i5440.
11. 王桂倩, 孫塑倫, 謝雁鳴, 等. 中醫臨床研究方案設計常見問題及其優化措施. 中華中醫藥雜志, 2017, 32(3): 935-938.
12. 毛兵, 王剛, 陳小東, 等. 《中國中西醫結合雜志》發表隨機對照試驗報告的質量評價. 中國循證醫學雜志, 2006, 6(4): 297-304.
13. 常靜, 李廷謙, 萬美華, 等. 中國4種中醫藥大學學報隨機對照臨床試驗文獻的質量評價. 中國循證醫學雜志, 2006, 6(3): 171-178.
14. 張明妍, 楊豐文, 李越, 等. 《中國中西醫結合雜志》刊載中醫藥隨機對照試驗報告質量的研究. 中國循證醫學雜志, 2017, 17(3): 357-363.
15. Gargon E, Gurung B, Medley N, et al. Choosing important health outcomes for comparative effectiveness research: a systematic review. PLoS One, 2014, 9(6): e99111.
16. 張明妍, 張俊華, 張伯禮. 2015年中藥治療穩定性心絞痛臨床試驗結局指標文獻研究. 中國中西醫結合雜志, 2018, 38(2): 191-197.
17. Taichman DB, Sahni P, Pinborg A, et al. Data sharing statements for clinical trials. BMJ, 2017, 357(23): 2372.
18. 吳泰相, 米娜瓦爾·阿不都, 郝園, 等. 中國臨床試驗注冊10年: 現狀與問題. 中國循證醫學雜志, 2018, 18(6): 522-525.
19. Xing DM, Sun Y, Zhu MJ, et al. The status of IRBs/ECs, ICFs and trial registration in clinical trials of traditional Chinese medicine for stable angina. Int J Cardiol, 2014, 174(2): 396-397.
20. 吳泰相, 卞兆祥, 李幼平, 等. 臨床試驗原始數據透明化與共享:關于醫學研究倫理的哲學命題及其對臨床試驗的意義. 中國循證醫學雜志, 2018, 18(6): 538-542.
21. 陳耀龍, 周奇, 崔榮榮, 等. 基于AGREE Ⅱ的中醫藥臨床指南質量評價. 中國循證醫學雜志, 2016, 16(11): 1331-1337.
22. ClinicalTrials. gov. Available at: http: //www. clinicaltrials. gov/.
23. 中國臨床試驗注冊中心. Available at: http: //www. chictr. org. cn/index. aspx.
24. 鄭文科. 發揮中醫藥優勢, 應對感染性疾病挑戰--第二屆循證中醫藥學國際論壇成功舉行. 天津中醫藥, 2017, 34(5): 289-290.
25. 邢冬梅, 張俊華, 張伯禮. 中醫臨床研究核心結局指標集形成路徑. 中華中醫藥雜志, 2014, 29(5): 1352-1355.
26. COMET Initiative. Available at: http://www.comet-initiative.org/.
27. 張伯禮: 以核心指標集研究為切入點推動中醫藥臨床研究質量提升. Available at: http://www.xinhuanet.com/health/2018-01/31/c_1122347918.htm.
28. Kirkham JJ, Gorst S, Altman DG, et al. COS-STAR: a reporting guideline for studies developing core outcome sets (protocol). Trials, 2015, 16(1): 373.
29. 中醫藥臨床證據數據庫. Available at: http://www.adrade.cn/evidence/index.
30. 發揮中醫藥優勢應對感染性疾病挑戰. Available at: http://news.xinhuanet.com/health/2017-04/25/c_1120868927.htm.

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