支氣管鏡介入治療在肺移植術后氣道并發癥的應用研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

葉澤慧 ,  王健

重慶醫科大學附屬兒童醫院呼吸科，國家兒童健康與疾病臨床醫學研究中心，兒童發育疾病研究教育部重點實驗室，兒童代謝與炎癥性疾病重慶市重點實驗室（重慶 400014）;

Corresponding?author：

王健, Email: dawangjiannihao@163.com

Keywords：

DOI：

10.7507/1671-6205.202405116

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Citation： 葉澤慧, 王健. 支氣管鏡介入治療在肺移植術后氣道并發癥的應用研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(1): 71-75. doi: 10.7507/1671-6205.202405116 Copy

1.	岳冰清, 陳靜瑜. 兒童肺移植治療. 中國實用兒科雜志, 2023, 38(3): 215-217.
2.	Cheng GS, Madtes DK, Edelman J, et al. Outcomes of lung transplantation after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, 2014, 20(8): 1169-1175.
3.	高霏, 衛棟, 吳波, 等. 雙肺移植治療骨髓移植術后閉塞性細支氣管炎一例報告并文獻復習. 中華血液學雜志, 2013, 34(8): 669-672.
4.	Iguidbashian J, Cotton J, King RW, et al. Survival following lung transplantation: A population-based nested case-control study. J Card Surg, 2022, 37(5): 1153-1160.
5.	Chambers DC, Perch M, Zuckermann A, et al. International Society for Heart and Lung Transplantation. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant, 2021, 40(10): 1060-1072.
6.	Delbove A, Senage T, Gazengel P, et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis, 2022, 16: 17534666221110354.
7.	Awori Hayanga JW, Aboagye JK, Shigemura N, et al. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant, 2016, 35(10): 1206-1211.
8.	Olland A, Reeb J, Puyraveau M, et al. Bronchial complications after lung transplantation are associated with primary lung graft dysfunction and surgical technique. J Heart Lung Transplant, 2017, 36(2): 157-165.
9.	Patoir A, Luchez A, Tiffet O, et al. Airway complications after lung transplantation: benefit of a conservative bronchoscopy strategy. J Thorac Dis, 2020, 12(5): 2625-2634.
10.	吳波, 張稷, 朱艷紅, 等. 肺移植術后氣道并發癥臨床分析. 南京醫科大學學報(自然科學版), 2009, 29(12): 1736-1738.
11.	Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest, 2017, 152(3): 627-638.
12.	Frye L, Machuzak M. Airway Complications After Lung Transplantation. Clin Chest Med, 2017, 38(4): 693-706.
13.	Crespo MM, McCarthy DP, Hopkins PM, et al. ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. J Heart Lung Transplant, 2018, 37(5): 548-563.
14.	Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis. Proc Am Thorac Soc, 2009, 6(1): 79-93.
15.	Debray MP, Dauriat G, Khalil A, et al. Diagnostic accuracy of low-mA chest CT reconstructed with Model Based Iterative Reconstruction in the detection of early pleuro-pulmonary complications following a lung transplantation. Eur Radiol, 2016, 26(9): 3138-3146.
16.	吳波, 鄭明鋒, 張稷, 等. 肺移植術后氣道狹窄并發癥的診斷和治療. 中華器官移植雜志, 2012, 33(7): 422-425.
17.	史靈芝, 黃桁, 劉明昭, 等. 肺移植術后需要臨床干預的氣道狹窄患者生存結局的影響因素. 器官移植, 2024, 15(2): 236-243.
18.	Douros K, Kremmydas G, Grammeniatis V, et al. Helical multi-detector CT scan as a tool for diagnosing tracheomalacia in children. Pediatr Pulmonol, 2019, 54(1): 47-52.
19.	Tendulkar RD, Fleming PA, Reddy CA, et al. High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys, 2008, 70(3): 701-706.
20.	Walters DM, Kuckelman JP, Mulligan MS. Electromagnetic navigational bronchoscopic airway recanalization in patients with vanishing bronchus. J Surg Res, 2018, 231: 154-160.
21.	王婷, 張杰, 邱小建, 等. 氣管鏡下介入治療瘢痕性氣道狹窄的有效性及影響因素分析. 中華結核和呼吸雜志, 2020, 43(9): 784-790.
22.	Mora-Cuesta VM, Tello-Mena S, Izquierdo-Cuervo S, et al. Bronchial stenosis after lung transplantation from cDCD donors using simultaneous abdominal normothermic regional perfusion: a single-center experience. Transplantation, 2023, 107(11): 2415-2423.
23.	Liang W, Hu P, Guo W, et al. Appropriate treatment sessions of flexible bronchoscopic balloon dilation for patients with nonmalignant central airway stenosis. Ther Adv Respir Dis, 2019, 13: 1753466619831966.
24.	丁銀鋒, 李付琦, 黃海東, 等. 支氣管鏡介入治療肺移植術后中心氣道狹窄的療效分析. 中國呼吸與危重監護雜志, 2020, 19(3): 276-280.
25.	Greer M, Fuehner T, Warnecke G, et al. Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation. Am J Transplant, 2014, 14(10): 2400-2405.
26.	Davidson KR, Elmasri M, Wahidi MM, et al. Management of lung transplant bronchial stenosis with mitomycin C. J Bronchology Interv Pulmonol, 2019, 26(2): 124-128.
27.	倪彩云, 劉霞, 馬靜, 等. 支氣管鏡下冷凍治療兒童肉芽及瘢痕組織導致的下氣道狹窄及阻塞22例. 中華兒科雜志, 2012, 50(1): 45-49.
28.	許煊, 劉璽誠, 祝彬, 等. 支氣管鏡下氬等離子體凝固聯合二氧化碳冷凍技術治療小兒氣道支架置入術后肉芽組織增生八例. 中華兒科雜志, 2014, 52(5): 368-372.
29.	姚志剛, 吳波, 李賓, 等. 支氣管內型錯構瘤臨床病理學特征及氣管鏡下熱消融聯合冷凍治療. 國際呼吸雜志, 2014, 34(14): 1084-1087.
30.	謝寶松, 葉玲, 李國平, 等. 不同冷凍消融時間對兔氣管創傷性肉芽組織增生的影響及其作用機制. 中華醫學雜志, 2018, 98(44): 3587-3591.
31.	Daggett C, Daggett A, McBurney E, et al. Laser safety: the need for protocols. Cutis, 2020, 106(2): 87-92.
32.	徐翠容, 賈坤林, 龍苗, 等. 電子支氣管鏡下支架植入聯合氬氣刀治療惡性腫瘤引起中央氣道狹窄的臨床觀察. 臨床肺科雜志, 2016, 21(8): 1482-1485.
33.	李一詩, 楊麗, 郭述良. 呼吸介入消融技術的臨床應用. 中國實用內科雜志, 2022, 42(9): 712-716.
34.	王洪武, 金發光, 張楠. 氣道內金屬支架臨床應用中國專家共識. 中華肺部疾病雜志(電子版), 2021, 14(1): 5-10.
35.	Gottlieb J, Fuehner T, Dierich M, et al. Are metallic stents really safe? A long-term analysis in lung transplant recipients. Eur Respir J, 2009, 34(6): 1417-1422.
36.	Bottero S, Meucci D, Trozzi M, et al. Dehiscence of bronchial anastomosis after lung transplantation: a successful unconventional treatment. Ann Thorac Surg, 2018, 106(2): e81-e83.
37.	Duvvuri M, Motz K, Tsai HW, et al. Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal stenosis. J Vis Exp, 2020, 155: 10.3791/60483.
38.	耿玉梅, 王蘇網, 陳丹萍, 等. 西羅莫司洗脫支架對氣管支架內再狹窄的作用. 中山大學學報(醫學科學版), 2016, 37(1): 54-60.
39.	劉偉, 傅恩清, 謝永宏, 等. 氣管鏡介入治療支氣管內膜結核方法的探討. 中華肺部疾病雜志電子版, 2011, 4(3): 183-186.
40.	Mei-Sheng Riley M. Invasive Fungal infections among immunocompromised patients in critical care settings: infection prevention risk mitigation. Crit Care Nurs Clin North Am, 2021, 33(4): 395-405.
41.	Soetanto V, Grewal US, Mehta AC, et al. Early postoperative complications in lung transplant recipients. Indian J Thorac Cardiovasc Surg, 2022, 38(Suppl 2): 260-270.
42.	Gebremariam T, Gu Y, Alkhazraji S, et al. The Combination treatment of fosmanogepix and liposomal amphotericin B is superior to monotherapy in treating experimental invasive mold infections. Antimicrob Agents Chemother, 2022, 66(7): e0038022.
43.	Randhawa SK, Yang Z, Morkan DB, et al. One-year survival worse for lung retransplants relative to primary lung transplants. Ann Thorac Surg, 2022, 113(4): 1265-1273.
44.	Polastri M, Reed RM. Rehabilitative goals for patients undergoing lung retransplantation. J Yeungnam Med Sci, 2024, 41(2): 134-138.
45.	Yang J, Pan X, Fu S, et al. Pulmonary retransplantation. J Thorac Dis, 2018, 10(7): 4632-4636.

1. 岳冰清, 陳靜瑜. 兒童肺移植治療. 中國實用兒科雜志, 2023, 38(3): 215-217.
2. Cheng GS, Madtes DK, Edelman J, et al. Outcomes of lung transplantation after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, 2014, 20(8): 1169-1175.
3. 高霏, 衛棟, 吳波, 等. 雙肺移植治療骨髓移植術后閉塞性細支氣管炎一例報告并文獻復習. 中華血液學雜志, 2013, 34(8): 669-672.
4. Iguidbashian J, Cotton J, King RW, et al. Survival following lung transplantation: A population-based nested case-control study. J Card Surg, 2022, 37(5): 1153-1160.
5. Chambers DC, Perch M, Zuckermann A, et al. International Society for Heart and Lung Transplantation. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant, 2021, 40(10): 1060-1072.
6. Delbove A, Senage T, Gazengel P, et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis, 2022, 16: 17534666221110354.
7. Awori Hayanga JW, Aboagye JK, Shigemura N, et al. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant, 2016, 35(10): 1206-1211.
8. Olland A, Reeb J, Puyraveau M, et al. Bronchial complications after lung transplantation are associated with primary lung graft dysfunction and surgical technique. J Heart Lung Transplant, 2017, 36(2): 157-165.
9. Patoir A, Luchez A, Tiffet O, et al. Airway complications after lung transplantation: benefit of a conservative bronchoscopy strategy. J Thorac Dis, 2020, 12(5): 2625-2634.
10. 吳波, 張稷, 朱艷紅, 等. 肺移植術后氣道并發癥臨床分析. 南京醫科大學學報(自然科學版), 2009, 29(12): 1736-1738.
11. Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest, 2017, 152(3): 627-638.
12. Frye L, Machuzak M. Airway Complications After Lung Transplantation. Clin Chest Med, 2017, 38(4): 693-706.
13. Crespo MM, McCarthy DP, Hopkins PM, et al. ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. J Heart Lung Transplant, 2018, 37(5): 548-563.
14. Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis. Proc Am Thorac Soc, 2009, 6(1): 79-93.
15. Debray MP, Dauriat G, Khalil A, et al. Diagnostic accuracy of low-mA chest CT reconstructed with Model Based Iterative Reconstruction in the detection of early pleuro-pulmonary complications following a lung transplantation. Eur Radiol, 2016, 26(9): 3138-3146.
16. 吳波, 鄭明鋒, 張稷, 等. 肺移植術后氣道狹窄并發癥的診斷和治療. 中華器官移植雜志, 2012, 33(7): 422-425.
17. 史靈芝, 黃桁, 劉明昭, 等. 肺移植術后需要臨床干預的氣道狹窄患者生存結局的影響因素. 器官移植, 2024, 15(2): 236-243.
18. Douros K, Kremmydas G, Grammeniatis V, et al. Helical multi-detector CT scan as a tool for diagnosing tracheomalacia in children. Pediatr Pulmonol, 2019, 54(1): 47-52.
19. Tendulkar RD, Fleming PA, Reddy CA, et al. High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys, 2008, 70(3): 701-706.
20. Walters DM, Kuckelman JP, Mulligan MS. Electromagnetic navigational bronchoscopic airway recanalization in patients with vanishing bronchus. J Surg Res, 2018, 231: 154-160.
21. 王婷, 張杰, 邱小建, 等. 氣管鏡下介入治療瘢痕性氣道狹窄的有效性及影響因素分析. 中華結核和呼吸雜志, 2020, 43(9): 784-790.
22. Mora-Cuesta VM, Tello-Mena S, Izquierdo-Cuervo S, et al. Bronchial stenosis after lung transplantation from cDCD donors using simultaneous abdominal normothermic regional perfusion: a single-center experience. Transplantation, 2023, 107(11): 2415-2423.
23. Liang W, Hu P, Guo W, et al. Appropriate treatment sessions of flexible bronchoscopic balloon dilation for patients with nonmalignant central airway stenosis. Ther Adv Respir Dis, 2019, 13: 1753466619831966.
24. 丁銀鋒, 李付琦, 黃海東, 等. 支氣管鏡介入治療肺移植術后中心氣道狹窄的療效分析. 中國呼吸與危重監護雜志, 2020, 19(3): 276-280.
25. Greer M, Fuehner T, Warnecke G, et al. Paclitaxel-coated balloons in refractory nonanastomostic airway stenosis following lung transplantation. Am J Transplant, 2014, 14(10): 2400-2405.
26. Davidson KR, Elmasri M, Wahidi MM, et al. Management of lung transplant bronchial stenosis with mitomycin C. J Bronchology Interv Pulmonol, 2019, 26(2): 124-128.
27. 倪彩云, 劉霞, 馬靜, 等. 支氣管鏡下冷凍治療兒童肉芽及瘢痕組織導致的下氣道狹窄及阻塞22例. 中華兒科雜志, 2012, 50(1): 45-49.
28. 許煊, 劉璽誠, 祝彬, 等. 支氣管鏡下氬等離子體凝固聯合二氧化碳冷凍技術治療小兒氣道支架置入術后肉芽組織增生八例. 中華兒科雜志, 2014, 52(5): 368-372.
29. 姚志剛, 吳波, 李賓, 等. 支氣管內型錯構瘤臨床病理學特征及氣管鏡下熱消融聯合冷凍治療. 國際呼吸雜志, 2014, 34(14): 1084-1087.
30. 謝寶松, 葉玲, 李國平, 等. 不同冷凍消融時間對兔氣管創傷性肉芽組織增生的影響及其作用機制. 中華醫學雜志, 2018, 98(44): 3587-3591.
31. Daggett C, Daggett A, McBurney E, et al. Laser safety: the need for protocols. Cutis, 2020, 106(2): 87-92.
32. 徐翠容, 賈坤林, 龍苗, 等. 電子支氣管鏡下支架植入聯合氬氣刀治療惡性腫瘤引起中央氣道狹窄的臨床觀察. 臨床肺科雜志, 2016, 21(8): 1482-1485.
33. 李一詩, 楊麗, 郭述良. 呼吸介入消融技術的臨床應用. 中國實用內科雜志, 2022, 42(9): 712-716.
34. 王洪武, 金發光, 張楠. 氣道內金屬支架臨床應用中國專家共識. 中華肺部疾病雜志(電子版), 2021, 14(1): 5-10.
35. Gottlieb J, Fuehner T, Dierich M, et al. Are metallic stents really safe? A long-term analysis in lung transplant recipients. Eur Respir J, 2009, 34(6): 1417-1422.
36. Bottero S, Meucci D, Trozzi M, et al. Dehiscence of bronchial anastomosis after lung transplantation: a successful unconventional treatment. Ann Thorac Surg, 2018, 106(2): e81-e83.
37. Duvvuri M, Motz K, Tsai HW, et al. Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal stenosis. J Vis Exp, 2020, 155: 10.3791/60483.
38. 耿玉梅, 王蘇網, 陳丹萍, 等. 西羅莫司洗脫支架對氣管支架內再狹窄的作用. 中山大學學報(醫學科學版), 2016, 37(1): 54-60.
39. 劉偉, 傅恩清, 謝永宏, 等. 氣管鏡介入治療支氣管內膜結核方法的探討. 中華肺部疾病雜志電子版, 2011, 4(3): 183-186.
40. Mei-Sheng Riley M. Invasive Fungal infections among immunocompromised patients in critical care settings: infection prevention risk mitigation. Crit Care Nurs Clin North Am, 2021, 33(4): 395-405.
41. Soetanto V, Grewal US, Mehta AC, et al. Early postoperative complications in lung transplant recipients. Indian J Thorac Cardiovasc Surg, 2022, 38(Suppl 2): 260-270.
42. Gebremariam T, Gu Y, Alkhazraji S, et al. The Combination treatment of fosmanogepix and liposomal amphotericin B is superior to monotherapy in treating experimental invasive mold infections. Antimicrob Agents Chemother, 2022, 66(7): e0038022.
43. Randhawa SK, Yang Z, Morkan DB, et al. One-year survival worse for lung retransplants relative to primary lung transplants. Ann Thorac Surg, 2022, 113(4): 1265-1273.
44. Polastri M, Reed RM. Rehabilitative goals for patients undergoing lung retransplantation. J Yeungnam Med Sci, 2024, 41(2): 134-138.
45. Yang J, Pan X, Fu S, et al. Pulmonary retransplantation. J Thorac Dis, 2018, 10(7): 4632-4636.

Chinese Journal of Respiratory and Critical Care Medicine

支氣管鏡介入治療在肺移植術后氣道并發癥的應用研究進展

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