阻塞性睡眠呼吸暫停損害心臟的分子機制研究進展_Chinese Journal of Respiratory and Critical Care Medicine

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李文彪 ¹ ,  陳沁 ²

1. ;
2. ;

Corresponding?author：

陳沁, Email: 2014015@fjtcm.edu.cn

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DOI：

10.7507/1671-6205.202404001

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Citation： 李文彪, 陳沁. 阻塞性睡眠呼吸暫停損害心臟的分子機制研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(1): 64-70. doi: 10.7507/1671-6205.202404001 Copy

1.	Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med, 2009, 5(3): 263-276.
2.	Young T, Palta M, Dempsey J, et al. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ, 2009, 108(5): 246-249.
3.	Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol, 2013, 177(9): 1006-1014.
4.	Han Q, Yeung SC, Ip MSM, et al. Cellular mechanisms in intermittent hypoxia-induced cardiac damage in vivo. J Physiol Biochem, 2014, 70(1): 201-213.
5.	姚麗霞, 黃黛, 李芳, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者心臟結構及左心室功能的變化. 山東醫藥, 2016, 56(33): 65-67.
6.	Bao Q, Zhang B, Suo Y, et al. Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis. Elife, 2020, 9: e49923.
7.	Guan P, Sun Z, Wang N, et al. Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway. Life Sci, 2019, 233: 116748.
8.	李亭亭, 郭亞凈, 任靜, 等. 當歸補血湯通過促進線粒體自噬抑制心肌細胞凋亡改善慢性間歇性低氧小鼠心功能. 中國中藥雜志, 2022, 47(11): 3066-3072.
9.	Yang X, Shi Y, Zhang L, et al. Overexpression of filamin c in chronic intermittent hypoxia-induced cardiomyocyte apoptosis is a potential cardioprotective target for obstructive sleep apnea. Sleep Breath, 2019, 23(2): 493-502.
10.	Young T, Finn L, Peppard PE, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep, 2008, 31(8): 1071-1078.
11.	Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem, 2015, 97: 55-74.
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16.	Dizdaroglu M, Jaruga P. Mechanisms of free radical-induced damage to DNA. Free Radic Res, 2012, 46(4): 382-419.
17.	Zhang P, Wang Y, Wang H, et al. Sesamol alleviates chronic intermittent hypoxia-induced cognitive deficits via inhibiting oxidative stress and inflammation in rats. Neuroreport, 2021, 32(2): 105-111.
18.	Zhang X, Rui L, Wang M, et al. Sinomenine attenuates chronic intermittent hypoxia-induced lung injury by inhibiting inflammation and oxidative stress. Med Sci Monit, 2018, 24: 1574-1580.
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20.	Xiong M, Zhao Y, Mo H, et al. Intermittent hypoxia increases ROS/HIF-1α ‘related oxidative stress and inflammation and worsens bleomycin-induced pulmonary fibrosis in adult male C57BL/6J mice. Int Immunopharmacol, 2021, 100: 108165.
21.	Zhang H, Zhou L, Zhou Y, et al. Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway. Life Sci, 2021, 285: 119963.
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1. Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med, 2009, 5(3): 263-276.
2. Young T, Palta M, Dempsey J, et al. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ, 2009, 108(5): 246-249.
3. Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol, 2013, 177(9): 1006-1014.
4. Han Q, Yeung SC, Ip MSM, et al. Cellular mechanisms in intermittent hypoxia-induced cardiac damage in vivo. J Physiol Biochem, 2014, 70(1): 201-213.
5. 姚麗霞, 黃黛, 李芳, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者心臟結構及左心室功能的變化. 山東醫藥, 2016, 56(33): 65-67.
6. Bao Q, Zhang B, Suo Y, et al. Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis. Elife, 2020, 9: e49923.
7. Guan P, Sun Z, Wang N, et al. Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway. Life Sci, 2019, 233: 116748.
8. 李亭亭, 郭亞凈, 任靜, 等. 當歸補血湯通過促進線粒體自噬抑制心肌細胞凋亡改善慢性間歇性低氧小鼠心功能. 中國中藥雜志, 2022, 47(11): 3066-3072.
9. Yang X, Shi Y, Zhang L, et al. Overexpression of filamin c in chronic intermittent hypoxia-induced cardiomyocyte apoptosis is a potential cardioprotective target for obstructive sleep apnea. Sleep Breath, 2019, 23(2): 493-502.
10. Young T, Finn L, Peppard PE, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep, 2008, 31(8): 1071-1078.
11. Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem, 2015, 97: 55-74.
12. Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol, 2014, 24(10): R453-R462.
13. Ray PD, Huang B, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal, 2012, 24(5): 981-990.
14. Sarniak A, Lipinska J, Tytman K, et al. Endogenous mechanisms of reactive oxygen species (ROS) generation. Postepy Hig Med Dosw (Online), 2016, 70: 1150-1165.
15. Rhee SG. H2O2, a necessary evil for cell signaling. Science, 2006, 312(5782): 1882-1883.
16. Dizdaroglu M, Jaruga P. Mechanisms of free radical-induced damage to DNA. Free Radic Res, 2012, 46(4): 382-419.
17. Zhang P, Wang Y, Wang H, et al. Sesamol alleviates chronic intermittent hypoxia-induced cognitive deficits via inhibiting oxidative stress and inflammation in rats. Neuroreport, 2021, 32(2): 105-111.
18. Zhang X, Rui L, Wang M, et al. Sinomenine attenuates chronic intermittent hypoxia-induced lung injury by inhibiting inflammation and oxidative stress. Med Sci Monit, 2018, 24: 1574-1580.
19. Li X, Ying H, Zhang Z, et al. Sulforaphane attenuates chronic intermittent hypoxia-induced brain damage in mice via augmenting Nrf2 nuclear translocation and autophagy. Front Cell Neurosci, 2022, 16: 827527.
20. Xiong M, Zhao Y, Mo H, et al. Intermittent hypoxia increases ROS/HIF-1α ‘related oxidative stress and inflammation and worsens bleomycin-induced pulmonary fibrosis in adult male C57BL/6J mice. Int Immunopharmacol, 2021, 100: 108165.
21. Zhang H, Zhou L, Zhou Y, et al. Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway. Life Sci, 2021, 285: 119963.
22. Zhang X, Cheng H, Yuan Y, et al. Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea model. Aging (Albany NY), 2021, 13(14): 18870-18878.
23. Guan P, Sun Z, Luo L, et al. Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis. Life Sci, 2019, 225: 46-54.
24. Itoh K, Ishii T, Wakabayashi N, et al. Regulatory mechanisms of cellular response to oxidative stress. Free Radic Res, 1999, 31(4): 319-324.
25. Martin F, Deursen JMV, Shivdasani RA, et al. Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood, 1998, 91(9): 3459-3466.
26. Sihvola V, Levonen AL. Keap1 as the redox sensor of the antioxidant response. Arch Biochem Biophys, 2017, 617: 94-100.
27. Bellezza I, Giambanco I, Minelli A, et al. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res, 2018, 1865(5): 721-733.
28. Suzuki T, Yamamoto M. Molecular basis of the Keap1-Nrf2 system. Free Radic Biol Med, 2015, 88(Pt B): 93-100.
29. Sun Z, Guan P, Luo L, et al. Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation. Life Sci, 2020, 245: 117362.
30. Wang Q, Wang Y, Zhang J, et al. Silencing MR-1 protects against myocardial injury induced by chronic intermittent hypoxia by targeting Nrf2 through antioxidant stress and anti-inflammation pathways. J Healthc Eng, 2022, 2022: 3471447.
31. Zhou G, Li X, Hein DW, et al. Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart. J Am Coll Cardiol, 2008, 52(8): 655-666.
32. Basu S. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology, 2003, 189(1-2): 113-127.
33. Yin X, Zhou S, Zheng Y, et al. Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice. Toxicol Appl Pharmacol, 2014, 277(1): 58-66.
34. 周珊珊. Nrf2與MT的協同作用在保護慢性間歇性低氧所致心臟損傷中的作用. 吉林大學, 2015.
35. Kajarabille N, Latunde-dada GO. Programmed cell-death by ferroptosis: antioxidants as mitigators. Int J Mol Sci, 2019, 20(19): 4968.
36. Song J, Zhao Y, Zhen Y, et al. Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia. Pharm Biol, 2022, 60(1): 609-620.
37. Wong HS, Benoit B, Brand MD. Mitochondrial and cytosolic sources of hydrogen peroxide in resting C2C12 myoblasts. Free Radic Biol Med, 2019, 130: 140-150.
38. Vermot A, Petit-hartlein I, Smith SME, et al. NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology. Antioxidants (Basel), 2021, 10(6): 890.
39. Wang W, Gu H, Li W, et al. SRC-3 Knockout attenuates myocardial injury induced by chronic intermittent hypoxia in mice. Oxid Med Cell Longev, 2021, 2021: 6372430.
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阻塞性睡眠呼吸暫停損害心臟的分子機制研究進展

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