Expression of SIR2-related enzyme 1 in serum of patients with chronic obstructive pulmonary disease and its clinical significance_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 GUO Guohua , XIAO Jianhong , SONG Bin , ZENG Linmiao

Department of Respiratory Medicine, Mindong Hospital of Fujian Medical University, Fuan, Fujian 355000, P. R. China;

Corresponding?author：

GUO Guohua, Email: 277681575@qq.com

Keywords：

SIR2-related enzyme 1; Chronic obstructive pulmonary disease; Pulmonary function; Serum

DOI：

10.7507/1671-6205.201706042

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ObjectiveTo investigate the expression of SIR2-related enzyme 1 (SIRT1) in serum of patients with chronic obstructive pulmonary disease (COPD) and its clinical significance.MethodsForty patients with acute exacerbation of COPD (acute-COPD group) and 30 patients with stable COPD (stable-COPD group) were selected as study groups. Twenty healthy subjects were recruited as a control group. Serum SIRT1, nuclear factor (NF) -κB, and matrix metalloproteinases (MMP) -9 levels were detected by enzyme-linked immunosorbent assay and Western blot.ResultsCompared with the control group, the FEV₁%pred and FEV₁/FVC were significantly decreased in the acute COPD patients and the stable COPD patients (P<0.05). Compared with the stable-COPD group, FEV₁%pred and FEV₁/FVC were significantly decreased in the acute-COPD group (P<0.05). Compared with control group, the serum SIRT1 in the stable-COPD group and the acute-COPD group were significantly decreased, while NF-κB and MMP-9 were significantly increased (P<0.05). Compared with the stable-COPD group, SIRT1 in the acute-COPD group was significantly decreased, while NF-κB and MMP-9 were significantly increased (P<0.05). SIRT1 were positively correlated with FEV₁%pred (P<0.05) and FEV₁/FVC (P<0.05) in the COPD patients by Pearson linear correlation analysis. SIRT1 was negatively correlated with NF-κB (P<0.05) and MMP-9 (P<0.05).ConclusionIn COPD patients, decreased levels of serum SIRT1 is associates with decreased lung function, which may be used as a potential biomarker of COPD.

Citation： GUO Guohua, XIAO Jianhong, SONG Bin, ZENG Linmiao. Expression of SIR2-related enzyme 1 in serum of patients with chronic obstructive pulmonary disease and its clinical significance. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(4): 336-340. doi: 10.7507/1671-6205.201706042 Copy

1.	Conti V, Corbi G, Simeon V, et al. Aging-related changes in oxidative stress response of human endothelial cells. Aging Clin Experim Res, 2015, 27(4): 1-7.
2.	中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南 (2013 年修訂版). 中國醫學前沿雜志電子版, 2014, 6(2): 67-80.
3.	高薇. 醒腦靜對慢阻肺急性加重期呼吸衰竭患者肺功能與血氣分析的影響. 中醫藥導報, 2014(15): 51-53.
4.	張曉慧. 炎性細胞因子水平檢測對慢性阻塞性肺疾病的臨床意義. 海南醫學院學報, 2016, 22(3): 240-242.
5.	Testa G, Cacciatore F, Bianco A, et al. Chronic obstructive pulmonary disease and long-term mortality in elderly subjects with chronic heart failure. Aging Clin Experim Res, 2017, 29(6): 1-8.
6.	Mercado N, Ito K, Barnes PJ. Accelerated ageing of the lung in COPD: new concepts. Thorax, 2015, 70(5): 482-489.
7.	李芳, 關文霞, 任飛, 等. Sirt-1 和 Hif-1α 在慢性阻塞性肺疾病患者外周血單個核細胞中的表達及其意義. 吉林大學學報 (醫學版), 2015, 41(2): 356-361.
8.	Ondracek CR, Frappier V, Ringel AE, et al. Mutations that allow SIR2 orthologs to function in a NAD+-depleted environment. Cell Rep, 2017, 18(10): 2310-2319.
9.	Ganesan R, Hos NJ, Gutierrez S, et al. Salmonella typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. Plos Pathogens, 2017, 13(2): e1006227.
10.	Emamgholipour S, Hosseinnezhad A, Sahraian MA, et al. Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes. Life Sci, 2016, 145(8): 34-41.
11.	Zhong Y, Chen AF, Zhao J, et al. Serum levels of cathepsin D, sirtuin1, and endothelial nitric oxide synthase are correlatively reduced in elderly healthy people. Aging Clin Experim Res, 2016, 28(4): 641-645.
12.	Wong SY, Tang BL. SIRT1 as a therapeutic target for Alzheimer’s disease. Rev Neurosci, 2016, 27(8): 813-825.
13.	Testa G, Staurenghi E, Zerbinati C, et al. Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation. Redox Biol, 2016, 10(C): 24-33.
14.	Yanagisawa S, Papaioannou AI, Papaporfyriou A, et al. Decreased Serum Sirtuin-1 in COPD. Chest, 2017, 152(2): 343-352.
15.	Taka C, Hayashi R, Shimokawa K, et al. SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients. Int J Chron Obstruct Pulmon Dis, 2017, 12(8): 3237-3244.
16.	伍造端, 鄧立普. NF-κB 在慢性阻塞性肺疾病中的作用. 蛇志, 2015, 24(1): 60-61.
17.	Cui X, Chen Q, Dong Z, et al. Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB. Cell Death Dis, 2016, 7(10): e2403.
18.	李敏, 王宇宏, 李巍. 基質金屬蛋白酶 2, 9, 12 與慢性阻塞性肺疾病的臨床研究. 中國醫學創新, 2016, 13(2): 44-47.
19.	Nakamaru Y, Vuppusetty C, Wada H, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J, 2009, 23(9): 2810-2819.

1. Conti V, Corbi G, Simeon V, et al. Aging-related changes in oxidative stress response of human endothelial cells. Aging Clin Experim Res, 2015, 27(4): 1-7.
2. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南 (2013 年修訂版). 中國醫學前沿雜志電子版, 2014, 6(2): 67-80.
3. 高薇. 醒腦靜對慢阻肺急性加重期呼吸衰竭患者肺功能與血氣分析的影響. 中醫藥導報, 2014(15): 51-53.
4. 張曉慧. 炎性細胞因子水平檢測對慢性阻塞性肺疾病的臨床意義. 海南醫學院學報, 2016, 22(3): 240-242.
5. Testa G, Cacciatore F, Bianco A, et al. Chronic obstructive pulmonary disease and long-term mortality in elderly subjects with chronic heart failure. Aging Clin Experim Res, 2017, 29(6): 1-8.
6. Mercado N, Ito K, Barnes PJ. Accelerated ageing of the lung in COPD: new concepts. Thorax, 2015, 70(5): 482-489.
7. 李芳, 關文霞, 任飛, 等. Sirt-1 和 Hif-1α 在慢性阻塞性肺疾病患者外周血單個核細胞中的表達及其意義. 吉林大學學報 (醫學版), 2015, 41(2): 356-361.
8. Ondracek CR, Frappier V, Ringel AE, et al. Mutations that allow SIR2 orthologs to function in a NAD+-depleted environment. Cell Rep, 2017, 18(10): 2310-2319.
9. Ganesan R, Hos NJ, Gutierrez S, et al. Salmonella typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. Plos Pathogens, 2017, 13(2): e1006227.
10. Emamgholipour S, Hosseinnezhad A, Sahraian MA, et al. Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes. Life Sci, 2016, 145(8): 34-41.
11. Zhong Y, Chen AF, Zhao J, et al. Serum levels of cathepsin D, sirtuin1, and endothelial nitric oxide synthase are correlatively reduced in elderly healthy people. Aging Clin Experim Res, 2016, 28(4): 641-645.
12. Wong SY, Tang BL. SIRT1 as a therapeutic target for Alzheimer’s disease. Rev Neurosci, 2016, 27(8): 813-825.
13. Testa G, Staurenghi E, Zerbinati C, et al. Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation. Redox Biol, 2016, 10(C): 24-33.
14. Yanagisawa S, Papaioannou AI, Papaporfyriou A, et al. Decreased Serum Sirtuin-1 in COPD. Chest, 2017, 152(2): 343-352.
15. Taka C, Hayashi R, Shimokawa K, et al. SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients. Int J Chron Obstruct Pulmon Dis, 2017, 12(8): 3237-3244.
16. 伍造端, 鄧立普. NF-κB 在慢性阻塞性肺疾病中的作用. 蛇志, 2015, 24(1): 60-61.
17. Cui X, Chen Q, Dong Z, et al. Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB. Cell Death Dis, 2016, 7(10): e2403.
18. 李敏, 王宇宏, 李巍. 基質金屬蛋白酶 2, 9, 12 與慢性阻塞性肺疾病的臨床研究. 中國醫學創新, 2016, 13(2): 44-47.
19. Nakamaru Y, Vuppusetty C, Wada H, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J, 2009, 23(9): 2810-2819.

Chinese Journal of Respiratory and Critical Care Medicine

Expression of SIR2-related enzyme 1 in serum of patients with chronic obstructive pulmonary disease and its clinical significance

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