Plasma prealbumin, homocysteine levels and the correlation with high-sensitivity C-reactive protein and body mass index in patients with chronic obstructive pulmonary disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 NIE Xiaohong , ZHANG Yi , HE Hanfu , GU Qin

Department of Respiratory Medicine, The 416 Hospital of Nuclear Industry, The Second Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610051, P. R. China;

Corresponding?author：

NIE Xiaohong, Email: xhnie1226@sina.com

Keywords：

Chronic obstructive pulmonary disease; Prealbumin; Homocysteine; High-sensitivity C-reactive protein; Body mass index; Correlation analysis

DOI：

10.7507/1671-6205.201712026

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ObjectiveTo explore the changes of plasma prealbumin (PA), homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) levels before and after treatment in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and analyze the correlation of PA and Hcy with hs-CRP and body mass index (BMI).MethodsA total of 132 hospitalized AECOPD patients with GOLD lung function as grade III-IV were recruited as an experimental group and 45 healthy subjects as a control group. The levels of plasma PA, Hcy and hs-CRP were measured by automatic biochemical analyzer, and the main indexes of pulmonary function were determined in all subjects.ResultsCompared with the control group, the level of plasma PA before and after treatment in the experimental group decreased significantly [(146.49±36.53) mg/L and (219.60±41.29) mg/L vs. (269.48±42.63) mg/L], the level of plasma Hcy before and after treatment increased significantly [(16.44±5.21) μmol/L and (12.61±4.56) μmol /L vs. (10.13±3.25) μmol/L], and the levels of plasma hs-CRP before and after treatment increased significantly [(45.24±29.94) mg/L and (7.71±3.41) mg/L vs. (5.01±1.52) mg/L] (all P<0.05). The levels of plasma PA, Hcy and hs-CRP after treatment were significantly better than before treatment in the experimental group (allP<0.01). The plasma PA values before and after treatment were negatively correlated with the level of hs-CRP before and after treatment, and positively correlated with BMI (bothP<0.05).ConclusionsThe levels of plasma PA, Hcy and hs-CRP are significantly different before and after the treatment in AECOPD patients and the healthy controls. PA is negatively correlated with hs-CRP and positively correlated with BMI. The detection of plasma PA and Hcy can help to determine the condition and efficacy of patients with COPD, and PA can reflect the level of inflammation and nutritional status to a certain extent.

Citation： NIE Xiaohong, ZHANG Yi, HE Hanfu, GU Qin. Plasma prealbumin, homocysteine levels and the correlation with high-sensitivity C-reactive protein and body mass index in patients with chronic obstructive pulmonary disease. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(4): 331-335. doi: 10.7507/1671-6205.201712026 Copy

1.	Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology, 2017, 22(3): 575-601.
2.	邱川, 李明才, 武燕, 等. 慢性阻塞性肺疾病氣道炎癥的研究進展. 中國呼吸與危重監護雜志, 2011, 10(2): 196-199.
3.	孫洪巖, 程雪松, 周平, 等. 老年慢性阻塞性肺疾病急性加重期患者血清 hs-CRP Cys-C PA 變化及臨床意義. 安徽醫學, 2016, 6(37): 739-740.
4.	Mohan A, Arora S, Uniyal A, et al. Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India, 2017, 34(1): 3-8.
5.	高恒興, 溫中梅, 袁海波, 等. 慢性阻塞性肺病發病機制研究的最新進展. 中國老年學雜志, 2015, 35(19): 5668-5670.
6.	董燕燕, 陳光亮. 高同型半胱氨酸血癥危害及致病機制研究進展. 中國藥理學通報, 2014, 30(9): 1205-1208.
7.	Karkhah A, Ataee R, Ataie A. Morphine pre- and post-conditioning exacerbates apoptosis in rat hippocampus cells in a model of homocysteine-induced oxidative stress. Biomed Rep, 2017, 7(4): 309-313.
8.	慢性阻塞性肺疾病急性發作(AECOPD)診治專家組. 慢性阻塞性肺疾病急性加重(AECOPD)診治中國專家共識(2017 年更新版). 國際呼吸雜志, 2017, 37(14): 1041-1057.
9.	Wedzicha JA, Calverley PMA, Albert RK, et al. Prevention of COPD exacerbations: European Respiratory Society/ American Thoracic Society guideline. Eur Respir J, 2017, 50(3):1-12.
10.	麻雅婷, 李新軍, 楊明, 等. C 反應蛋白的研究進展及臨床應用. 臨床檢驗雜志(電子版), 2015, 4(4): 997-1002.
11.	Jing Z, Chun C, Ning S, et al. Systemic inflammatory marker CRP was better predictor of readmission for AECOPD than sputum inflammatory markers. Arch Bronconeumol, 2016, 52(3): 138-144.
12.	Gao D, Chen X, Wu H, et al. The levels of serum pro-calcitonin and high-sensitivity C-reactive protein in the early diagnosis ofchronic obstructive pulmonary disease during acute exacerbation. Exp Ther Med, 2017, 14(1): 193-198.
13.	Gaudiani JL, Sabel AL, Mehler PS. Low prealbumin is a significant predictor of medical complications in severe anorexianervosa. Int J Eat Disord, 2014, 47(2): 148-156.
14.	孫佳, 張艷華, 劉樹軍, 等. 老年慢性疾病與血清前白蛋白關系的研究進展. 吉林大學學報(醫學版), 2016, 42(1): 186-190.
15.	陶新曹, 林江濤, 劉國梁, 等. 血清前白蛋白水平評價呼吸危重癥患者預后的價值. 中日友好醫院學報, 2015, 18(3): 158-160.
16.	諸興桂, 葉兆萍, 曾垂利, 等. 前白蛋白對慢性阻塞性肺疾病的診斷與病原菌感染的影響研究. 中華醫院感染學雜志, 2016, 26(15): 3387-3388, 3397.
17.	趙彥楠, 楊博逸, 孫貴范. 同型半胱氨酸與主要慢性病關系研究進展. 中國公共衛生, 2015, 31(2): 241-245.
18.	Khan NA, Saini H, Mawari G, et al. The effect of folic acid supplementation on hyperhomocysteinemia and pulmonary function parameters in chronic obstructive pulmonary disease: a pilot study. J Clin Diagn Res, 2016, 10(11): OC17-OC21.
19.	Beleti? A, Mirkovi? D, Dudvarski-Ili? A, et al. Questionable reliability of homocysteine as the metabolic marker for folate and vitamin B12 deficiency in patients with chronic obstructive pulmonary disease. J Med Biochem, 2015, 34(4): 467-472.
20.	楊雪嬌, 趙國厚, 袁開芬. 血清同型半胱氨酸與慢阻肺相關性的研究進展. 中國老年保健醫學, 2015, 13(4): 76-77.
21.	Seemungal TA, Lun JC, Davis G, et al. Plasma homocysteine is elevated in COPD patients and is related to COPD severity. Int J Chron Obstruct Pulmon Dis, 2007, 2(3): 313-321.
22.	楊海濤, 劉海峰, 王海彥. Hcy、NO 及 IL-8 在慢性阻塞性肺疾病中的變化與意義. 中國醫藥導刊, 2015, 17(30): 246-247.
23.	胡萍, 王娟, 張運劍. 慢性阻塞性肺疾病患者同型半胱氨酸及血脂水平分析. 中華全科醫學, 2017, 15 (10): 1711-1713, 1751.

1. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary. Respirology, 2017, 22(3): 575-601.
2. 邱川, 李明才, 武燕, 等. 慢性阻塞性肺疾病氣道炎癥的研究進展. 中國呼吸與危重監護雜志, 2011, 10(2): 196-199.
3. 孫洪巖, 程雪松, 周平, 等. 老年慢性阻塞性肺疾病急性加重期患者血清 hs-CRP Cys-C PA 變化及臨床意義. 安徽醫學, 2016, 6(37): 739-740.
4. Mohan A, Arora S, Uniyal A, et al. Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease. Lung India, 2017, 34(1): 3-8.
5. 高恒興, 溫中梅, 袁海波, 等. 慢性阻塞性肺病發病機制研究的最新進展. 中國老年學雜志, 2015, 35(19): 5668-5670.
6. 董燕燕, 陳光亮. 高同型半胱氨酸血癥危害及致病機制研究進展. 中國藥理學通報, 2014, 30(9): 1205-1208.
7. Karkhah A, Ataee R, Ataie A. Morphine pre- and post-conditioning exacerbates apoptosis in rat hippocampus cells in a model of homocysteine-induced oxidative stress. Biomed Rep, 2017, 7(4): 309-313.
8. 慢性阻塞性肺疾病急性發作(AECOPD)診治專家組. 慢性阻塞性肺疾病急性加重(AECOPD)診治中國專家共識(2017 年更新版). 國際呼吸雜志, 2017, 37(14): 1041-1057.
9. Wedzicha JA, Calverley PMA, Albert RK, et al. Prevention of COPD exacerbations: European Respiratory Society/ American Thoracic Society guideline. Eur Respir J, 2017, 50(3):1-12.
10. 麻雅婷, 李新軍, 楊明, 等. C 反應蛋白的研究進展及臨床應用. 臨床檢驗雜志(電子版), 2015, 4(4): 997-1002.
11. Jing Z, Chun C, Ning S, et al. Systemic inflammatory marker CRP was better predictor of readmission for AECOPD than sputum inflammatory markers. Arch Bronconeumol, 2016, 52(3): 138-144.
12. Gao D, Chen X, Wu H, et al. The levels of serum pro-calcitonin and high-sensitivity C-reactive protein in the early diagnosis ofchronic obstructive pulmonary disease during acute exacerbation. Exp Ther Med, 2017, 14(1): 193-198.
13. Gaudiani JL, Sabel AL, Mehler PS. Low prealbumin is a significant predictor of medical complications in severe anorexianervosa. Int J Eat Disord, 2014, 47(2): 148-156.
14. 孫佳, 張艷華, 劉樹軍, 等. 老年慢性疾病與血清前白蛋白關系的研究進展. 吉林大學學報(醫學版), 2016, 42(1): 186-190.
15. 陶新曹, 林江濤, 劉國梁, 等. 血清前白蛋白水平評價呼吸危重癥患者預后的價值. 中日友好醫院學報, 2015, 18(3): 158-160.
16. 諸興桂, 葉兆萍, 曾垂利, 等. 前白蛋白對慢性阻塞性肺疾病的診斷與病原菌感染的影響研究. 中華醫院感染學雜志, 2016, 26(15): 3387-3388, 3397.
17. 趙彥楠, 楊博逸, 孫貴范. 同型半胱氨酸與主要慢性病關系研究進展. 中國公共衛生, 2015, 31(2): 241-245.
18. Khan NA, Saini H, Mawari G, et al. The effect of folic acid supplementation on hyperhomocysteinemia and pulmonary function parameters in chronic obstructive pulmonary disease: a pilot study. J Clin Diagn Res, 2016, 10(11): OC17-OC21.
19. Beleti? A, Mirkovi? D, Dudvarski-Ili? A, et al. Questionable reliability of homocysteine as the metabolic marker for folate and vitamin B12 deficiency in patients with chronic obstructive pulmonary disease. J Med Biochem, 2015, 34(4): 467-472.
20. 楊雪嬌, 趙國厚, 袁開芬. 血清同型半胱氨酸與慢阻肺相關性的研究進展. 中國老年保健醫學, 2015, 13(4): 76-77.
21. Seemungal TA, Lun JC, Davis G, et al. Plasma homocysteine is elevated in COPD patients and is related to COPD severity. Int J Chron Obstruct Pulmon Dis, 2007, 2(3): 313-321.
22. 楊海濤, 劉海峰, 王海彥. Hcy、NO 及 IL-8 在慢性阻塞性肺疾病中的變化與意義. 中國醫藥導刊, 2015, 17(30): 246-247.
23. 胡萍, 王娟, 張運劍. 慢性阻塞性肺疾病患者同型半胱氨酸及血脂水平分析. 中華全科醫學, 2017, 15 (10): 1711-1713, 1751.

Chinese Journal of Respiratory and Critical Care Medicine

Plasma prealbumin, homocysteine levels and the correlation with high-sensitivity C-reactive protein and body mass index in patients with chronic obstructive pulmonary disease

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