Epidemiological status and trends of colorectal cancer in China and the United States_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Lin ¹ , LI Xu ¹ , TAN Kun ² , DENG Ren ² , GAO Linna ³ ,  WANG Xiaodong ⁴

1. Center of Biostatistics, Design, Measurement and Evaluation (CBDME), Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Sichuan Provincial Health Information Center, Chengdu 610041, P. R. China;
3. Department of Gastrointestinal Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030000, P. R. China;
4. Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

WANG Xiaodong, Email: wangxiaodong@wchscu.cn

Keywords：

colorectal cancer; incidence; mortality; prevention

DOI：

10.7507/1007-9424.202505086

Video：

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Objective To compare the epidemiological status and trends of colorectal cancer in China and the United States, and to summarize the respective prevention and screening strategies. Methods Based on relevant data such as the Global cancer statistics (2022), Cancer statistics (2025), the China Cancer Burden of Disease Report (2022), and the China-United States colorectal cancer epidemiology report, the incidence, mortality and trends of colorectal cancer in China and the United States were analyzed. Results From 2000 to 2018, age-standardized incidence rate of colorectal cancer in China increased by an average of 2.7% per year for men and 1.1% per year for women, with an average annual mortality increase of 1.2% for men and a decrease of 0.3% per year for women. Colorectal cancer mortality decreased by an average of 1.2% per year in the United States in 2011–2021 and by an average of 1.7% per year in 2013–2022, and the 5-year relative survival rate for colorectal cancer increased from 50% in 1975–1977 to 64% in 2014–2020. Conclusions The incidence and mortality of colorectal cancer in the United States have shown a downward trend, and the survival rate of patients is increasing. The situation in our country is different: the incidence continues to rise, the mortality is higher than the United States, and although the survival rate has improved, it is still not at the level of the United States. China continues to face a heavy burden of colorectal cancer. To enhance colorectal cancer prevention and treatment, it is essential to establish a new multi-stakeholder collaborative framework for disease control, ultimately forming a colorectal cancer management system with Chinese characteristics, thereby effectively reducing the national colorectal cancer disease burden.

Citation： LI Lin, LI Xu, TAN Kun, DENG Ren, GAO Linna, WANG Xiaodong. Epidemiological status and trends of colorectal cancer in China and the United States. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2025, 32(6): 694-701. doi: 10.7507/1007-9424.202505086 Copy

1.	Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
2.	Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent, 2024, 4(1): 47-53.
3.	Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA Cancer J Clin, 2025, 75(1): 10-45.
4.	Siegel RL, Wagle NS, Cercek A, et al. Colorectal cancer statistics, 2023. CA Cancer J Clin, 2023, 73(3): 233-254.
5.	Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin, 1999, 49(1): 33-64.
6.	Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
7.	Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
8.	Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
9.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
10.	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
11.	王裕新, 潘凱楓, 李文慶. 2022全球癌癥統計報告解讀. 腫瘤綜合治療電子雜志, 2024, 10(3): 1-16.
12.	鄭榮壽, 陳茹, 韓冰峰, 等. 2022年中國惡性腫瘤流行情況分析. 中華腫瘤雜志, 2024, 46(3): 221-231.
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14.	Chen WQ, Zeng HM, Zheng RS, et al. Cancer incidence and mortality in China, 2007. Chin J Cancer Res, 2012, 24(1): 1-8.
15.	Chen W, Zheng R, Zhang S, et al. Cancer incidence and mortality in China, 2013. Cancer Lett, 2017, 401: 63-71.
16.	Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014. Chin J Cancer Res, 2018, 30(1): 1-12.
17.	趙文靜, 尹周一, 王裕新, 等. 2024美國癌癥統計報告解讀及中美癌癥流行情況對比. 腫瘤防治研究, 2024, 51(8): 630-641.
18.	尹周一, 王夢圓, 游偉程, 等. 2022美國癌癥統計報告解讀及中美癌癥流行情況對比. 腫瘤綜合治療電子雜志, 2022, 8(2): 54-63.
19.	黃理賓, 黃秋實, 楊烈. 全球及中國的結直腸癌流行病學特征及防治: 2022《全球癌癥統計報告》解讀. 中國普外基礎與臨床雜志, 2024, 31(5): 530-537.
20.	張金珠, 楊明, 王錫山. 中國、美國及世界結直腸癌流行病學與疾病負擔的對比和思考. 中華結直腸疾病電子雜志, 2024, 13(2): 89-93.
21.	王錫山. 從中美結直腸癌流行病學特征看結直腸癌早診早治的重要性. 中華結直腸疾病電子雜志, 2021, 10(1): 26-33.
22.	胡志強, 游偉程, 潘凱楓, 等. 中、美兩國癌癥流行特征分析—《2023美國癌癥統計報告》解讀. 科技導報, 2023, 41(18): 18-28.
23.	練佳韋, 劉穎春, 余紅平. 結直腸癌的全球流行情況、危險因素及歸因疾病負擔研究進展. 中國癌癥防治雜志, 2024, 16(1): 1-9.
24.	郭蘭偉, 張興龍, 蔡林, 等. 全球結直腸癌流行和防控現狀. 中華腫瘤雜志, 2024, 46(1): 57-65.
25.	中華醫學會腫瘤學分會早診早治學組. 中國結直腸癌早診早治專家共識 (2023版). 中華普通外科學文獻 (電子版), 2024, 18(1): 1-13.
26.	鄭瑩, 王澤洲. 全球結直腸癌流行數據解讀. 中華流行病學雜志, 2021, 42(1): 149-152.

1. Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries. CA Cancer J Clin, 2024, 74(3): 229-263.
2. Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022. J Natl Cancer Cent, 2024, 4(1): 47-53.
3. Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA Cancer J Clin, 2025, 75(1): 10-45.
4. Siegel RL, Wagle NS, Cercek A, et al. Colorectal cancer statistics, 2023. CA Cancer J Clin, 2023, 73(3): 233-254.
5. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin, 1999, 49(1): 33-64.
6. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin, 2005, 55(2): 74-108.
7. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
8. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin, 2015, 65(2): 87-108.
9. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
10. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
11. 王裕新, 潘凱楓, 李文慶. 2022全球癌癥統計報告解讀. 腫瘤綜合治療電子雜志, 2024, 10(3): 1-16.
12. 鄭榮壽, 陳茹, 韓冰峰, 等. 2022年中國惡性腫瘤流行情況分析. 中華腫瘤雜志, 2024, 46(3): 221-231.
13. Chen WQ, Zhang SW, Zou XN, et al. Cancer incidence and mortality in China, 2006. Chin J Cancer Res, 2011, 23(1): 3-9.
14. Chen WQ, Zeng HM, Zheng RS, et al. Cancer incidence and mortality in China, 2007. Chin J Cancer Res, 2012, 24(1): 1-8.
15. Chen W, Zheng R, Zhang S, et al. Cancer incidence and mortality in China, 2013. Cancer Lett, 2017, 401: 63-71.
16. Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014. Chin J Cancer Res, 2018, 30(1): 1-12.
17. 趙文靜, 尹周一, 王裕新, 等. 2024美國癌癥統計報告解讀及中美癌癥流行情況對比. 腫瘤防治研究, 2024, 51(8): 630-641.
18. 尹周一, 王夢圓, 游偉程, 等. 2022美國癌癥統計報告解讀及中美癌癥流行情況對比. 腫瘤綜合治療電子雜志, 2022, 8(2): 54-63.
19. 黃理賓, 黃秋實, 楊烈. 全球及中國的結直腸癌流行病學特征及防治: 2022《全球癌癥統計報告》解讀. 中國普外基礎與臨床雜志, 2024, 31(5): 530-537.
20. 張金珠, 楊明, 王錫山. 中國、美國及世界結直腸癌流行病學與疾病負擔的對比和思考. 中華結直腸疾病電子雜志, 2024, 13(2): 89-93.
21. 王錫山. 從中美結直腸癌流行病學特征看結直腸癌早診早治的重要性. 中華結直腸疾病電子雜志, 2021, 10(1): 26-33.
22. 胡志強, 游偉程, 潘凱楓, 等. 中、美兩國癌癥流行特征分析—《2023美國癌癥統計報告》解讀. 科技導報, 2023, 41(18): 18-28.
23. 練佳韋, 劉穎春, 余紅平. 結直腸癌的全球流行情況、危險因素及歸因疾病負擔研究進展. 中國癌癥防治雜志, 2024, 16(1): 1-9.
24. 郭蘭偉, 張興龍, 蔡林, 等. 全球結直腸癌流行和防控現狀. 中華腫瘤雜志, 2024, 46(1): 57-65.
25. 中華醫學會腫瘤學分會早診早治學組. 中國結直腸癌早診早治專家共識 (2023版). 中華普通外科學文獻 (電子版), 2024, 18(1): 1-13.
26. 鄭瑩, 王澤洲. 全球結直腸癌流行數據解讀. 中華流行病學雜志, 2021, 42(1): 149-152.

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Epidemiological status and trends of colorectal cancer in China and the United States

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