Application value of three-dimensional contrast-enhanced ultrasound angiography in differential diagnosis of breast masses_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Hongmei , WEI Tao ,  XIONG Runqing

Department of Ultrasound, The Second Hospital of Xiamen, Xiamen, Fujian 361021, P.R.China;

Corresponding?author：

XIONG Runqing, Email: xiongrunqing75@163.com

Keywords：

breast masses; three-dimensional contrast-enhanced ultrasound angiography; two-dimensional ultrasound; differential diagnosis; value; new blood vessels

DOI：

10.7507/1007-9424.201608044

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the value of three-dimensional contrast-enhanced ultrasound angiography in the differential diagnosis of breast masses. Methods A total of 120 patients with breast masses who were treated in our hospital from July 2013 to February 2016 were selected as the research objects retrospectively, including 70 patients of benign tumor (benign group) and 50 patients of malignant tumor (malignant group) that confirmed by surgery and pathology. All patients were given conventional two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography during the diagnosis. Compared the imaging features of benign group and malignant group, and compared the diagnostic value of two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography for breast masses. Results Compared with benign group, the rates of irregular masses, unclear boundary, inhomogeneous echo, lateral shadowing, echo attenuation, and micro calcification in the malignant group were all higher (P<0.05). The three-dimensional contrast-enhanced ultrasound angiography scores in malignant group and benign group were significantly different with each other (P<0.05), the score of the malignant group was higher than that of benign group. The 2- and 3-score was common in benign group, but 4- and 5-score was common in malignant group. The diagnostic sensitivity of two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography for breast masses were 97.1% (68/70) and 98.6% (69/70) respectively, and the specificity were 80.0% (40/50) and 96.0% (48/50) respectively, the specificity of three-dimensional contrast-enhanced ultrasound angiography was significantly higher than that of two-dimensional ultrasound (P<0.05). Conclusion Two-dimensional ultrasound and three-dimensional contrast-enhanced ultrasound angiography both have a certain diagnostic value in the differential diagnosis of breast masses, but the three dimensional contrast-enhanced ultrasound angiography can get more information through assessment of richness of the microvascular in tumor tissue, so as to improve the diagnostic specificity and is worthy of popularization and application.

Citation： WANG Hongmei, WEI Tao, XIONG Runqing. Application value of three-dimensional contrast-enhanced ultrasound angiography in differential diagnosis of breast masses. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(3): 333-337. doi: 10.7507/1007-9424.201608044 Copy

1.	?王曄, 李國杰, 朱向明, 等. 超聲顯像對乳腺疾病的診斷進展. 中華全科醫學, 2013, 11(4): 613-614.
2.	閆晨曦, 楊麗春. 乳腺癌的超聲診斷現狀及新技術應用進展. 醫學綜述, 2012, 18(12): 1919-1921.
3.	Liu D, Huang Y, Tian D,et al. Value of sonographic bidirectional arterial flow combined with elastography for diagnosis of breast imaging reporting and data system category 4 breast masses. J Ultrasound Med, 2015, 34(5): 759-766.
4.	李明慧, 劉翼, 柳莉莎, 等. 實時組織彈性成像和三維超聲造影在乳腺腫塊鑒別診斷中的應用價值. 中華醫學雜志, 2016, 96(19): 1515-1518.
5.	Chen L, Chen Y, Diao XH,et al. Comparative study of automated breast 3-D ultrasound and handheld B-mode ultrasound for differentiation of benign and malignant breast masses. Ultrasound Med Biol, 2013, 39(10): 1735-1742.
6.	程玉玲, 周軍. 二維、三維超聲及超聲造影在乳腺癌診療中的應用進展. 海南醫學, 2015, 22(13): 1949-1951.
7.	王志遠, 周啟昌. 乳腺惡性腫瘤診斷及療效監測的超聲研究新進展. 臨床超聲醫學雜志, 2014, 16(3): 185-187.
8.	Huang YH, Chen JH, Chang YC,et al. Diagnosis of solid breast tumors using vessel analysis in three-dimensional power Doppler ultrasound images. J Digit Imaging, 2013, 26(4): 731-739.
9.	李明慧, 劉翼, 李慧敏. 乳腺腫瘤動態三維超聲造影的誤診分析. 中國醫藥導刊, 2016, 18(5): 437-439.
10.	Lo CM, Moon WK, Huang CS,et al. Intensity-invariant texture analysis for classification of BI-RADS category 3 breast masses. Ultrasound Med Biol, 2015, 41(7): 2039-2048.
11.	O’Connell AM, Karellas A, Vedantham S. The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples. Breast J, 2014, 20(6): 592-605.
12.	柯文, 耿峰. 乳腺癌超聲診斷技術的研究進展. 海軍醫學雜志, 2013, 34(6): 429-431.
13.	紀甜甜, 趙青, 翟虹. 超聲聲觸診量化在乳腺腫塊良、惡性鑒別中的價值分析. 腫瘤學雜志, 2016, 22(1): 57-60.
14.	Trottmann M, Marcon J, D’Anastasi M,et al. Shear-wave elastography of the testis in the healthy man —— determination of standard values. Clin Hemorheol Microcirc, 2016, 62(3): 273-281.
15.	Li Z, Tian J, Wang X,et al. Differences in multi-modal ultrasound imaging between triple negative and non-triple negative breast cancer. Ultrasound Med Biol, 2016, 42(4): 882-890.
16.	鄭磊, 呂夕明, 黃福光, 等. 乳腺硬化性腺病的超聲診斷價值. 中華超聲影像學雜志, 2016, 25(3): 263-264.
17.	Kupeli A, Kul S, Eyuboglu I,et al. Role of 3D power Doppler ultrasound in the further characterization of suspicious breast masses. Eur J Radiol, 2016, 85(1): 1-6.
18.	Kuzmiak CM, Ko EY, Tuttle LA,et al. Whole breast ultrasound: comparison of the visibility of suspicious lesions with automated breast volumetric scanningversus hand-held breast ultrasound. Acad Radiol, 2015, 22(7): 870-879.
19.	蔣艷平, 王欣, 李友芳. 高頻彩色多普勒超聲在鑒別診斷乳腺腫塊的應用價值. 現代診斷與治療, 2016, 27(1): 17-19.
20.	Clauser P, Londero V, Como G,et al. Comparison between different imaging techniques in the evaluation of malignant breast lesions: can 3D ultrasound be useful? Radiol Med, 2014, 119(4): 240-248.
21.	張麗芝, 曾涵江, 黃子星, 等. MRI 擴散加權成像對乳腺浸潤性導管癌新輔助化療效果的評價. 中國普外基礎與臨床雜志, 2013, 20(1): 88-91.
22.	鐘穎, 孫強, 黃漢源, 等. 妊娠期乳腺癌的診斷和治療. 中國普外基礎與臨床雜志, 2012, 19(12): 1332-1334.
23.	張偉民. 高頻超聲聯合鉬靶 X 線攝影診斷乳腺腫塊的效果和價值. 中國實用醫刊, 2016, 43(22): 120-122.
24.	李志華, 常愛敏, 吳剛. 基層醫院 76 例乳腺腫塊細針穿刺細胞學與組織病理學對照分析. 中國現代醫生, 2016, 54(6): 88-90.
25.	周瑋珺, 孔文韜, 張捷, 等. 超聲影像學報告及數據系統鑒別乳腺腫塊良惡性的多因素分析. 腫瘤學雜志, 2016, 22(4): 265-268.

1. ?王曄, 李國杰, 朱向明, 等. 超聲顯像對乳腺疾病的診斷進展. 中華全科醫學, 2013, 11(4): 613-614.
2. 閆晨曦, 楊麗春. 乳腺癌的超聲診斷現狀及新技術應用進展. 醫學綜述, 2012, 18(12): 1919-1921.
3. Liu D, Huang Y, Tian D,et al. Value of sonographic bidirectional arterial flow combined with elastography for diagnosis of breast imaging reporting and data system category 4 breast masses. J Ultrasound Med, 2015, 34(5): 759-766.
4. 李明慧, 劉翼, 柳莉莎, 等. 實時組織彈性成像和三維超聲造影在乳腺腫塊鑒別診斷中的應用價值. 中華醫學雜志, 2016, 96(19): 1515-1518.
5. Chen L, Chen Y, Diao XH,et al. Comparative study of automated breast 3-D ultrasound and handheld B-mode ultrasound for differentiation of benign and malignant breast masses. Ultrasound Med Biol, 2013, 39(10): 1735-1742.
6. 程玉玲, 周軍. 二維、三維超聲及超聲造影在乳腺癌診療中的應用進展. 海南醫學, 2015, 22(13): 1949-1951.
7. 王志遠, 周啟昌. 乳腺惡性腫瘤診斷及療效監測的超聲研究新進展. 臨床超聲醫學雜志, 2014, 16(3): 185-187.
8. Huang YH, Chen JH, Chang YC,et al. Diagnosis of solid breast tumors using vessel analysis in three-dimensional power Doppler ultrasound images. J Digit Imaging, 2013, 26(4): 731-739.
9. 李明慧, 劉翼, 李慧敏. 乳腺腫瘤動態三維超聲造影的誤診分析. 中國醫藥導刊, 2016, 18(5): 437-439.
10. Lo CM, Moon WK, Huang CS,et al. Intensity-invariant texture analysis for classification of BI-RADS category 3 breast masses. Ultrasound Med Biol, 2015, 41(7): 2039-2048.
11. O’Connell AM, Karellas A, Vedantham S. The potential role of dedicated 3D breast CT as a diagnostic tool: review and early clinical examples. Breast J, 2014, 20(6): 592-605.
12. 柯文, 耿峰. 乳腺癌超聲診斷技術的研究進展. 海軍醫學雜志, 2013, 34(6): 429-431.
13. 紀甜甜, 趙青, 翟虹. 超聲聲觸診量化在乳腺腫塊良、惡性鑒別中的價值分析. 腫瘤學雜志, 2016, 22(1): 57-60.
14. Trottmann M, Marcon J, D’Anastasi M,et al. Shear-wave elastography of the testis in the healthy man —— determination of standard values. Clin Hemorheol Microcirc, 2016, 62(3): 273-281.
15. Li Z, Tian J, Wang X,et al. Differences in multi-modal ultrasound imaging between triple negative and non-triple negative breast cancer. Ultrasound Med Biol, 2016, 42(4): 882-890.
16. 鄭磊, 呂夕明, 黃福光, 等. 乳腺硬化性腺病的超聲診斷價值. 中華超聲影像學雜志, 2016, 25(3): 263-264.
17. Kupeli A, Kul S, Eyuboglu I,et al. Role of 3D power Doppler ultrasound in the further characterization of suspicious breast masses. Eur J Radiol, 2016, 85(1): 1-6.
18. Kuzmiak CM, Ko EY, Tuttle LA,et al. Whole breast ultrasound: comparison of the visibility of suspicious lesions with automated breast volumetric scanningversus hand-held breast ultrasound. Acad Radiol, 2015, 22(7): 870-879.
19. 蔣艷平, 王欣, 李友芳. 高頻彩色多普勒超聲在鑒別診斷乳腺腫塊的應用價值. 現代診斷與治療, 2016, 27(1): 17-19.
20. Clauser P, Londero V, Como G,et al. Comparison between different imaging techniques in the evaluation of malignant breast lesions: can 3D ultrasound be useful? Radiol Med, 2014, 119(4): 240-248.
21. 張麗芝, 曾涵江, 黃子星, 等. MRI 擴散加權成像對乳腺浸潤性導管癌新輔助化療效果的評價. 中國普外基礎與臨床雜志, 2013, 20(1): 88-91.
22. 鐘穎, 孫強, 黃漢源, 等. 妊娠期乳腺癌的診斷和治療. 中國普外基礎與臨床雜志, 2012, 19(12): 1332-1334.
23. 張偉民. 高頻超聲聯合鉬靶 X 線攝影診斷乳腺腫塊的效果和價值. 中國實用醫刊, 2016, 43(22): 120-122.
24. 李志華, 常愛敏, 吳剛. 基層醫院 76 例乳腺腫塊細針穿刺細胞學與組織病理學對照分析. 中國現代醫生, 2016, 54(6): 88-90.
25. 周瑋珺, 孔文韜, 張捷, 等. 超聲影像學報告及數據系統鑒別乳腺腫塊良惡性的多因素分析. 腫瘤學雜志, 2016, 22(4): 265-268.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Application value of three-dimensional contrast-enhanced ultrasound angiography in differential diagnosis of breast masses

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content