Clinical analysis of influence factors for lymph node metastasis of early gastric cancer patients_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yinzhong , ZHANG Yanping ,  HAN Chaoyang , FU Yanzhong , WANG Juan

Department of General Surgery Area 1, The First Affiliated Hospital of Henan Polytechnic University, The Second People’s Hospital of Jiaozuo, Jiaozuo, Henan 454000, P.R.China;

Corresponding?author：

HAN Chaoyang, Email: dhcy@126.com

Keywords：

early gastric cancer; lymph node metastasis; influence factor

DOI：

10.7507/1007-9424.201607007

Video：

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Objective To explore the clinicopathological characteristics which were associated with lymph node metastases in early gastric cancer patients. Methods Clinical data of 187 early gastric cancer patients who received surgical treatment in The Second People’s Hospital of Jiaozuo between January 2009 and January 2016, were retrospectively analyzed, and then exploring the clinicopathological characteristics which were associated with lymph node metastases in early gastric cancer, including age, gender, tumor location, diameter of tumor, number of tumor, depth of invasion, macroscopic type, histological type, venous invasion, and local ulcer. Results In this study, 187 patients with early gastric cancer were included, and lymph node metastasis was detected in 32 patients (17.1%). Results of multivariate logistic regression analysis showed that, lymph node metastasis was significantly closely related with diameter of tumor (OR=2.080,P=0.022), depth of invasion (OR=21.048,P=0.001), histological type (OR=3.507,P=0.018), venous invasion (OR=2.406,P=0.009), and local ulcer (OR=2.738,P=0.001), patients with diameter of tumor larger than 2 cm, infiltration depth of submucosa, histological types of undifferentiated type, vascular infiltration, and local ulcer had higher lymph node metastasis rate. Conclusion The clinicopathological characteristics, including diameter of tumor, depth of invasion, histological type, venous invasion, and local ulcer are risk factors for lymph node metastasis of early gastric cancer patients, which should be paid high attention.

Citation： WANG Yinzhong, ZHANG Yanping, HAN Chaoyang, FU Yanzhong, WANG Juan. Clinical analysis of influence factors for lymph node metastasis of early gastric cancer patients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(3): 328-332. doi: 10.7507/1007-9424.201607007 Copy

1.	?李誠, 周健, 裘炯良. 胃癌流行病學與分子生物學病因的研究進展. 腫瘤防治研究, 2004, 31(2): 115-118.
2.	李華, 霍志斌, 吳殿超, 等. 內鏡下治療未分化型早期胃癌的臨床研究. 中國腫瘤臨床, 2015, 42(19): 969-972.
3.	羅來斌, 黃湖南, 鄭馬亮, 等. 早期胃癌患者淋巴結轉移的危險因素分析. 實用臨床醫學(江西), 2013, 14(3): 46-48.
4.	Wang Y. The predictive factors for lymph node metastasis in early gastric cancer: a clinical study. Pak J Med Sci, 2015, 31(6): 1437-1440.
5.	何新陽, 邵峰, 梁偉, 等. 215例早期胃癌淋巴結轉移的危險因素分析. 中國腫瘤臨床, 2013, 40(2): 97-99.
6.	Hirasawa T, Gotoda T, Miyata S,et al. Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiatedtype early gastric cancer. Gastric Cancer, 2009, 12(3): 148-152.
7.	Feng XY, Wang W, Luo GY,et al. Comparison of endoscopic ultrasonography and multislice spiral computed tomography for the preoperative staging of gastric cancer-results of a single institution study of 610 Chinese patients. PLoS One, 2013, 8(11): e78846.
8.	鄭瑞, 聶明明, 張新, 等. 早期胃癌淋巴結轉移與臨床病理因素關系的臨床研究. 中華普外科手術學雜志(電子版), 2012, 6(2): 18-20.
9.	Abe N, Watanabe T, Suzuki K,et al. Risk factors predictive of lymph node metastasis in depressed early gastric cancer. Am J Surg, 2002, 183(2): 168-172.
10.	Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma-2nd English edition. Gastric Cancer, 1998, 1(1): 10-24.
11.	苗儒林, 李子禹, 季加孚. 早期胃癌的規范化治療. 中國普外基礎與臨床雜志, 2014, 21(1): 16-20.
12.	涂朝勇, 朱錦德, 邵初曉, 等. 影響早期胃癌淋巴結轉移的臨床病理因素分析. 浙江實用醫學, 2011, 16(5): 336-338.
13.	Kim KJ, Park SJ, Moon W,et al. Analysis of factors related to lymph node metastasis in undifferentiated early gastric cancer. Turk J Gastroenterol, 2011, 22(2): 139-144.
14.	Shen L, Huang Y, Sun M,et al. Clinicopathological characteristics associated with lymph node metastasis in early gastric cancer with submucosal invasion. Chinese J Pract Surg, 2012, 29(1): 91-93.
15.	張頑軍, 潘文勝, 許晶虹, 等. 早期胃癌淋巴轉移臨床病理因素探討. 實用腫瘤雜志, 2010, 25(5): 553-556.
16.	孟祥彩. 早期胃癌淋巴結轉移危險因素分析. 石家莊: 河北醫科大學, 2014: 31-35.
17.	張丹杰, 車向明, 李海軍, 等. 胃癌組織學類型與預后的關系. 中國普外基礎與臨床雜志, 2011, 18(5): 545-548.
18.	Lee JH, Nam BH, Ryu KW,et al. Tumor differentiation is not a risk factor for lymph node metastasis in elderly patients with early gastric cancer. Eur J Surg Oncol, 2014, 40(12): 1771-1776.
19.	畢鐵男, 馮杏君, 蘭躍福, 等. 老年與青年早期胃癌淋巴結轉移危險因素對比分析. 中華全科醫學, 2013, 11(11): 1673-1675.
20.	蔣志凌, 鄧桂英. 早期胃癌臨床病理特征與浸潤深度的關系. 華西醫學, 2014, 29(11): 2050-2054.
21.	Ren G, Cai R, Zhang WJ,et al. Prediction of risk factors for lymph node metastasis in early gastric cancer. World J Gastroenterol, 2013, 19(20): 3096-3107.
22.	于會生, 王九菊, 劉松玲, 等. 上海、洛陽兩地胃癌發生部位分析. 河南腫瘤學雜志, 2002, 15(4): 253-255.
23.	Yamamoto S, Nishida T, Kato M,et al. Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth. Gastroenterol Res Pract, 2012, 2012: 194530.
24.	朱敏, 李明陽, 吳本儼. 早期胃癌內鏡下切除術后復發的相關因素分析. 中華內科雜志, 2011, 50(5): 366-369.

1. ?李誠, 周健, 裘炯良. 胃癌流行病學與分子生物學病因的研究進展. 腫瘤防治研究, 2004, 31(2): 115-118.
2. 李華, 霍志斌, 吳殿超, 等. 內鏡下治療未分化型早期胃癌的臨床研究. 中國腫瘤臨床, 2015, 42(19): 969-972.
3. 羅來斌, 黃湖南, 鄭馬亮, 等. 早期胃癌患者淋巴結轉移的危險因素分析. 實用臨床醫學(江西), 2013, 14(3): 46-48.
4. Wang Y. The predictive factors for lymph node metastasis in early gastric cancer: a clinical study. Pak J Med Sci, 2015, 31(6): 1437-1440.
5. 何新陽, 邵峰, 梁偉, 等. 215例早期胃癌淋巴結轉移的危險因素分析. 中國腫瘤臨床, 2013, 40(2): 97-99.
6. Hirasawa T, Gotoda T, Miyata S,et al. Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiatedtype early gastric cancer. Gastric Cancer, 2009, 12(3): 148-152.
7. Feng XY, Wang W, Luo GY,et al. Comparison of endoscopic ultrasonography and multislice spiral computed tomography for the preoperative staging of gastric cancer-results of a single institution study of 610 Chinese patients. PLoS One, 2013, 8(11): e78846.
8. 鄭瑞, 聶明明, 張新, 等. 早期胃癌淋巴結轉移與臨床病理因素關系的臨床研究. 中華普外科手術學雜志(電子版), 2012, 6(2): 18-20.
9. Abe N, Watanabe T, Suzuki K,et al. Risk factors predictive of lymph node metastasis in depressed early gastric cancer. Am J Surg, 2002, 183(2): 168-172.
10. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma-2nd English edition. Gastric Cancer, 1998, 1(1): 10-24.
11. 苗儒林, 李子禹, 季加孚. 早期胃癌的規范化治療. 中國普外基礎與臨床雜志, 2014, 21(1): 16-20.
12. 涂朝勇, 朱錦德, 邵初曉, 等. 影響早期胃癌淋巴結轉移的臨床病理因素分析. 浙江實用醫學, 2011, 16(5): 336-338.
13. Kim KJ, Park SJ, Moon W,et al. Analysis of factors related to lymph node metastasis in undifferentiated early gastric cancer. Turk J Gastroenterol, 2011, 22(2): 139-144.
14. Shen L, Huang Y, Sun M,et al. Clinicopathological characteristics associated with lymph node metastasis in early gastric cancer with submucosal invasion. Chinese J Pract Surg, 2012, 29(1): 91-93.
15. 張頑軍, 潘文勝, 許晶虹, 等. 早期胃癌淋巴轉移臨床病理因素探討. 實用腫瘤雜志, 2010, 25(5): 553-556.
16. 孟祥彩. 早期胃癌淋巴結轉移危險因素分析. 石家莊: 河北醫科大學, 2014: 31-35.
17. 張丹杰, 車向明, 李海軍, 等. 胃癌組織學類型與預后的關系. 中國普外基礎與臨床雜志, 2011, 18(5): 545-548.
18. Lee JH, Nam BH, Ryu KW,et al. Tumor differentiation is not a risk factor for lymph node metastasis in elderly patients with early gastric cancer. Eur J Surg Oncol, 2014, 40(12): 1771-1776.
19. 畢鐵男, 馮杏君, 蘭躍福, 等. 老年與青年早期胃癌淋巴結轉移危險因素對比分析. 中華全科醫學, 2013, 11(11): 1673-1675.
20. 蔣志凌, 鄧桂英. 早期胃癌臨床病理特征與浸潤深度的關系. 華西醫學, 2014, 29(11): 2050-2054.
21. Ren G, Cai R, Zhang WJ,et al. Prediction of risk factors for lymph node metastasis in early gastric cancer. World J Gastroenterol, 2013, 19(20): 3096-3107.
22. 于會生, 王九菊, 劉松玲, 等. 上海、洛陽兩地胃癌發生部位分析. 河南腫瘤學雜志, 2002, 15(4): 253-255.
23. Yamamoto S, Nishida T, Kato M,et al. Evaluation of endoscopic ultrasound image quality is necessary in endosonographic assessment of early gastric cancer invasion depth. Gastroenterol Res Pract, 2012, 2012: 194530.
24. 朱敏, 李明陽, 吳本儼. 早期胃癌內鏡下切除術后復發的相關因素分析. 中華內科雜志, 2011, 50(5): 366-369.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical analysis of influence factors for lymph node metastasis of early gastric cancer patients

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