Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 沈宏 ,  趙冬雨 , 張寧

武警后勤學院附屬醫院普通外科（天津 300162）;

Corresponding?author：

趙冬雨, Email: 185082583@qq.com

Keywords：

結直腸癌; 修復基因; XRCC1; Arg194Trp; 基因多態性; 易感性

DOI：

10.7507/1007-9424.20140114

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的探討DNA損傷修復基因XRCC1 Arg194Trp位點多態性與結直腸癌易感性的關系。方法選取120例結直腸癌患者與120例正常對照者進行對比研究。取外周血提取DNA，采用限制性片段長度多態性聚合酶鏈反應（PCR-RFLP）技術對XRCC1 Arg194Trp基因多態性進行檢測分析，比較不同基因型與結直腸癌易感性的關系。結果 2組觀察對象在年齡、性別、吸煙、飲酒、飲食特點等常見暴露因素方面的差異均無統計學意義（P＞0.05），變異基因型Arg/Trp＋Trp/Trp出現頻率在2組觀察對象中分別為30.00%和24.17%，差異無統計學意義（P＞0.05）。結論 XRCC1 Arg194Trp位點多態性與結直腸癌的易感性并無顯著相關性。

Citation： 沈宏, 趙冬雨, 張寧. Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 476-478. doi: 10.7507/1007-9424.20140114 Copy

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4.	王永兵, 何苗, 程宏文. BRCA1、XRCC1基因多態性與乳腺癌易感性研究進展[J].中國醫藥導報, 2012, 9(33):30-31.
5.	黃姍, 易斌, 楊星海, 等.結直腸癌患者的DNA修復基因XRCC1單核苷酸多態研究[J].中華實驗外科雜志, 2010, 27(8):1057-1059.
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9.	趙波, 鐘華戈, 吳衛, 等.結直腸癌危險因素的流行病學研究進展[J].結直腸肛門外科, 2013, 19(3):199-202.
10.	Ruffinengo O, Tanno F, Covernton J, et al. Colorectal cancer:epidemiologic characteristics in a hospital center of Rosario, Arge-ntina[J]. Acta Gastroenterol Latinoam, 2010, 40(2):98-104.
11.	李莉, 黃河浪.結直腸癌發生危險因素的流行病學研究進展[J].結直腸肛門外科, 2010, 16(6):397-401.
12.	Gsur A, Bernhart K, Baierl A, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk[J]. Cancer Epidemiol, 2011, 35(5):e38-e41.
13.	Lee JM, Lee YC, Yang SY, et al. Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer[J]. Int J Cancer, 2001, 95(4):240-246.
14.	Huang YS, Li LG, Yu L, et al. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk:a meta-analysis[J]. Mutagenesis, 2009, 24(4):331-339.
15.	宋春英, 譚文, 林東昕.中國人DNA修復基因XRCC1單核苷酸多態及其與食管癌風險的關系[J].癌癥, 2001, 20(1):28-31.
16.	Yin G, Morita M, Ohnaka K, et al. Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan[J]. J Epidemiol, 2012, 22(1):64-71.
17.	Skjelbred CF, Saeb? M, Wallin H, et al. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort:a case control study[J]. BMC Cancer, 2006, 6:67.

1. Colditz GA, McGowan LD, James AS, et al. Screening for colorectal cancer:using data to set prevention priorities[J]. Cancer Causes Control, 2014, 25(1):93-98.
2. Lieberman D. Screening for colorectal cancer in individuals at average risk:current methods and emerging issues[J]. JAMA Intern Med, 2014, 174(1):10-11.
3. 萬德森.結直腸癌流行病學與預防[J].中國中西醫結合外科雜志, 2011, 17(1):3-8.
4. 王永兵, 何苗, 程宏文. BRCA1、XRCC1基因多態性與乳腺癌易感性研究進展[J].中國醫藥導報, 2012, 9(33):30-31.
5. 黃姍, 易斌, 楊星海, 等.結直腸癌患者的DNA修復基因XRCC1單核苷酸多態研究[J].中華實驗外科雜志, 2010, 27(8):1057-1059.
6. 葉慈慈, 黃智銘, 周春燕, 等. APE1D148E、PARP1 V762A、XRCC1 R399Q的多態性與結直腸癌的易患性[J].世界華人消化雜志, 2010, 18(12):1275-1279.
7. 宋潔云, 劉芳宏, 馬軍, 等.酚/氯仿法和鹽析法提取人類外周血基因組DNA方法的比較[J].中國實驗診斷學, 2013, 17(5):802-805.
8. Chen K, Cai J, Liu XY, et al. Nested case-control study on the risk factors of colorectal cancer[J]. World J Gastroenterol, 2003, 9(1):99-103.
9. 趙波, 鐘華戈, 吳衛, 等.結直腸癌危險因素的流行病學研究進展[J].結直腸肛門外科, 2013, 19(3):199-202.
10. Ruffinengo O, Tanno F, Covernton J, et al. Colorectal cancer:epidemiologic characteristics in a hospital center of Rosario, Arge-ntina[J]. Acta Gastroenterol Latinoam, 2010, 40(2):98-104.
11. 李莉, 黃河浪.結直腸癌發生危險因素的流行病學研究進展[J].結直腸肛門外科, 2010, 16(6):397-401.
12. Gsur A, Bernhart K, Baierl A, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk[J]. Cancer Epidemiol, 2011, 35(5):e38-e41.
13. Lee JM, Lee YC, Yang SY, et al. Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer[J]. Int J Cancer, 2001, 95(4):240-246.
14. Huang YS, Li LG, Yu L, et al. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk:a meta-analysis[J]. Mutagenesis, 2009, 24(4):331-339.
15. 宋春英, 譚文, 林東昕.中國人DNA修復基因XRCC1單核苷酸多態及其與食管癌風險的關系[J].癌癥, 2001, 20(1):28-31.
16. Yin G, Morita M, Ohnaka K, et al. Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan[J]. J Epidemiol, 2012, 22(1):64-71.
17. Skjelbred CF, Saeb? M, Wallin H, et al. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort:a case control study[J]. BMC Cancer, 2006, 6:67.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer

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