Research Progress of Pulmonary Ground-glass Opacity_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

TIANLong , SHENCheng ,  CHEGuo-wei

Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, P. R. China;

Corresponding?author：

CHEGuo-wei, Email: chebenben2005@163.com

Keywords：

Lung cancer; Ground-glass opacity; Diagnosis; Treatment; Surgery

DOI：

10.7507/1007-4848.20150098

Video：

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Abstract Full text Figures/Tables Video References Cited by

Increasing evidence suggests that there is a close relationship between pulmonary ground-glass opacity (GGO) and early-stage lung cancer, especially bronchial alveolar carcinoma in the early stage. With the use of high-resolution computed tomography (HRCT) and positron emission tomography/computed tomography (PET/CT), more and more GGO patients have been identified. Correct diagnosis and surgical indications should be determined according to the image characteristics including proportion and size of GGO in a pulmonary nodule as well as intraoperative quick pathological examination to avoid unnecessary surgical resection. Therefore, early detection and correct diagnosis of GGO are very important to improve patient prognosis.

Citation： TIANLong, SHENCheng, CHEGuo-wei. Research Progress of Pulmonary Ground-glass Opacity. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(4): 371-374. doi: 10.7507/1007-4848.20150098 Copy

1.	Miura A, Akagi S, Nakamura K, et al.Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis.Cardiovascular Pathology, 2013, 22(4):287-293.
2.	雷志丹, 葛英輝, 史大鵬.肺部彌漫性磨玻璃陰影的CT診斷與鑒別診斷.中國醫學影像技術, 2007, 23(8):1147-1151.
3.	雷志丹, 王思勤, 史大鵬.特發性間質性肺炎的HRCT診斷.實用診斷與治療雜志, 2006, 20(3):198-201.
4.	劉建東, 廖強, 李建國.肺部磨玻璃密度影的CT診斷與鑒別診斷.中國當代醫藥, 2011, 18(13):94-97.
5.	Nakamura S, Fukui T, Taniguchi T, et al.Prognostic impact of tumor size eliminating the ground glass opacity component modi-fied clinical T descriptors of the tumor, node, metastasis classifica——tion of lung cancer.J Thorac Oncol, 2013, 8(12):1551-1557.
6.	Miao XH, Yao YW, Yuan DM, et al.Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma:A meta-analysis.J Thorac Dis, 2012, 4(3):265-271.
7.	張麗萍, 徐海, 杜春華, 等.肺磨玻璃樣病變HRCT征象的診斷價值.江蘇醫藥, 2013, 39(8):969-970.
8.	張善華, 王和平, 王善軍, 等.肺部局灶性磨玻璃影的CT診斷.醫學影像學雜志, 2012, 22(8):1329-1332.
9.	Kim HY, Shim YM, Lee KS, et al.Persistent pulmonary nodular ground-glass opacity at thin-section CT:histopathologic compari-sons.Radiology, 2007, 245(1):267-275.
10.	Park JH, Lee KS, Kim JH, et al.Malignant pure pulmonary ground-glass opacity nodules:prognostic implications.Kor J Radio, 2009, 10(1):12-20.
11.	王琦, 時高峰, 王士杰.薄層CT和動態觀察對肺部磨玻璃結節的診斷價值.臨床薈萃, 2011, 26(6):512-515, 封3.
12.	Henschke CI, Yankelevitz DF, Mirtcheva R, et al.CT screening for lung cancer:Frequency and significance of part-solid and nonsolid nodules.Am J Roentgenol, 2002, 178(5):1053-1057.
13.	Lee HY, Choi YL, Lee KS, et al.Pure ground-glass opacity neoplastic lung nodules:histopathology, imaging, and management.Am J Roentgenol, 2014, 202(3):W224-W233.
14.	Fischer BM, Mortensen J.The future in diagnosis and staging of lung cancer:Positron emission tomography.Respiration, 2006, 73(3):267-276.
15.	柳偉坤, 李向東, 全江濤, 等.18F-FDG PET/CT顯像對孤立結節型細支氣管肺泡癌的診斷價值.南方醫科大學學報, 2013, 33(1):114-116.
16.	Tao W, Chang P, Changhai Y, et al.FDG-PET in bronchial alveolar carcinoma.Chinese-German J Clin Oncol, 2006, 5(1):54-57.
17.	潘建虎, 郝建, 歐小波, 等.18F-FDG PET/CT掃描對孤立性肺結節病診斷價值的探討.臨床肺科雜志, 2011, 16(10):1490-1491.
18.	Bruzzi JF, Munden RF.PET/CT imaging of lung cancer.J Thorac Imaging, 2006, 21(2):123-136.
19.	何寶明, 王志忠, 劉曉飛, 等.細支氣管肺泡癌18F FDG PET/CT SUV值與HRCT形態學的相關性研究.科學技術與工程, 2011, 11(35):8858-8861.
20.	Nakayama H, Okumura S, Daisaki H, et al.Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma a multicenter study.Cancer, 2010, 116(13):3170-3177.
21.	Takeda A, Kunieda E, Fujii H, et al.Evaluation for local failure by 18F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer.Lung Cancer, 2013, 79(3):248-253.
22.	Uehara H, Tsutani Y, Okumura S, et al.Prognostic role of positron emission tomography and high-resolution computed tomography in clinical stage IA lung adenocarcinoma.Ann Thorac Surg, 2013, 96(6):1958-1965.
23.	Chun EJ, Lee HJ, Kang WJ, et al.Differentiation between malignancy and inflammation in pulmonary ground-glass nodules:The feasibility of integrated 18F-FDG PET/CT.Lung Cancer, 2009, 65(2):180-186.
24.	Ichinose J, Kohno T, Fujimori S, et al.Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities.Ann Thorac Cardiovas Surg, 2014, 20(5):347-352.
25.	Sakata I, Ozeki Y, Tamura K, et al.A case of early stage lung cancer detected by repeated cancer screening with positron emission tomography.Oncol Lett, 2012, 3(2):297-299.
26.	張麗萍, 陳成水.肺部單發磨玻璃樣結節的最新研究進展.醫學研究雜志, 2011, 40(2):13-15, 2.
27.	郭峰, 張志庸, 崔玉尚, 等.肺局限性磨玻璃樣病灶的外科處理.中國肺癌雜志, 2008, 11(5):739-741.
28.	虞桂平, 黃斌, 陳國強, 等.電視胸腔鏡在肺部局限性磨玻璃樣病灶手術中的應用.江蘇醫藥, 2012, 38(22):2768-2768.
29.	潘小杰, 郭天興, 葉明凡, 等.胸腔鏡手術聯合PET/CT診療44例肺磨玻璃樣病變臨床分析.腫瘤防治研究, 2013, 40(7):706-708.
30.	Yan TD, Black D, Bannon PG, et al.Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer.J Clin Oncol, 2009, 27(15):2553-2562.
31.	Kohno T, Fujimori S, Kishi K, et al.Safe and effective minimally invasive approaches for small ground glass opacity.Ann Thorac Surg, 2010, 89(6):S2114-S2117.
32.	Tsutani Y, Miyata Y, Nakayama HA, et al.Prediction of pathologic node-negative clinical stage IA lung adenocarcinoma for optimal candidates undergoing sublobar resection.J Thorac Cardiovasc Surg, 2012, 144(6):1365-1371.
33.	魏立, 趙松, 陳明耀, 等.精確CT引導定位局限性肺磨玻璃影的臨床病理和手術模式探討.實用醫學雜志, 2012, 28(22):3723-3725.
34.	Tsutani Y, Miyata Y, Nakayama H, et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma.Chest, 2014, 145(1):66-71.
35.	Sugi K, Kobayashi S, Sudou M, et al.Long-term prognosis of video-assisted limited surgery for early lung cancer.Eur J Cardio-Thorac Surg, 2010, 37(2):456-460.
36.	Yoshida J, Nagai K, Yokose T, et al.Limited resection trial for pulmonary ground-glass opacity nodules:fifty-case experience.J Thorac Cardiovasc Surg, 2005, 129(5):991-996.
37.	Matsuguma H, Nakahara R, Anraku M, et al.Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung.Euro J Cardio-Thorac Surg, 2004, 25(6):1102-1105.
38.	Ohtsuka T, Watanabe KI, Kaji M, et al.A clinicopathological study of resected putmonary nodules with focal pure ground-glass opacity.Euro J Cardio-Thorac Surg, 2006, 30(1):160-163.

1. Miura A, Akagi S, Nakamura K, et al.Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis.Cardiovascular Pathology, 2013, 22(4):287-293.
2. 雷志丹, 葛英輝, 史大鵬.肺部彌漫性磨玻璃陰影的CT診斷與鑒別診斷.中國醫學影像技術, 2007, 23(8):1147-1151.
3. 雷志丹, 王思勤, 史大鵬.特發性間質性肺炎的HRCT診斷.實用診斷與治療雜志, 2006, 20(3):198-201.
4. 劉建東, 廖強, 李建國.肺部磨玻璃密度影的CT診斷與鑒別診斷.中國當代醫藥, 2011, 18(13):94-97.
5. Nakamura S, Fukui T, Taniguchi T, et al.Prognostic impact of tumor size eliminating the ground glass opacity component modi-fied clinical T descriptors of the tumor, node, metastasis classifica——tion of lung cancer.J Thorac Oncol, 2013, 8(12):1551-1557.
6. Miao XH, Yao YW, Yuan DM, et al.Prognostic value of the ratio of ground glass opacity on computed tomography in small lung adenocarcinoma:A meta-analysis.J Thorac Dis, 2012, 4(3):265-271.
7. 張麗萍, 徐海, 杜春華, 等.肺磨玻璃樣病變HRCT征象的診斷價值.江蘇醫藥, 2013, 39(8):969-970.
8. 張善華, 王和平, 王善軍, 等.肺部局灶性磨玻璃影的CT診斷.醫學影像學雜志, 2012, 22(8):1329-1332.
9. Kim HY, Shim YM, Lee KS, et al.Persistent pulmonary nodular ground-glass opacity at thin-section CT:histopathologic compari-sons.Radiology, 2007, 245(1):267-275.
10. Park JH, Lee KS, Kim JH, et al.Malignant pure pulmonary ground-glass opacity nodules:prognostic implications.Kor J Radio, 2009, 10(1):12-20.
11. 王琦, 時高峰, 王士杰.薄層CT和動態觀察對肺部磨玻璃結節的診斷價值.臨床薈萃, 2011, 26(6):512-515, 封3.
12. Henschke CI, Yankelevitz DF, Mirtcheva R, et al.CT screening for lung cancer:Frequency and significance of part-solid and nonsolid nodules.Am J Roentgenol, 2002, 178(5):1053-1057.
13. Lee HY, Choi YL, Lee KS, et al.Pure ground-glass opacity neoplastic lung nodules:histopathology, imaging, and management.Am J Roentgenol, 2014, 202(3):W224-W233.
14. Fischer BM, Mortensen J.The future in diagnosis and staging of lung cancer:Positron emission tomography.Respiration, 2006, 73(3):267-276.
15. 柳偉坤, 李向東, 全江濤, 等.18F-FDG PET/CT顯像對孤立結節型細支氣管肺泡癌的診斷價值.南方醫科大學學報, 2013, 33(1):114-116.
16. Tao W, Chang P, Changhai Y, et al.FDG-PET in bronchial alveolar carcinoma.Chinese-German J Clin Oncol, 2006, 5(1):54-57.
17. 潘建虎, 郝建, 歐小波, 等.18F-FDG PET/CT掃描對孤立性肺結節病診斷價值的探討.臨床肺科雜志, 2011, 16(10):1490-1491.
18. Bruzzi JF, Munden RF.PET/CT imaging of lung cancer.J Thorac Imaging, 2006, 21(2):123-136.
19. 何寶明, 王志忠, 劉曉飛, 等.細支氣管肺泡癌18F FDG PET/CT SUV值與HRCT形態學的相關性研究.科學技術與工程, 2011, 11(35):8858-8861.
20. Nakayama H, Okumura S, Daisaki H, et al.Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma a multicenter study.Cancer, 2010, 116(13):3170-3177.
21. Takeda A, Kunieda E, Fujii H, et al.Evaluation for local failure by 18F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer.Lung Cancer, 2013, 79(3):248-253.
22. Uehara H, Tsutani Y, Okumura S, et al.Prognostic role of positron emission tomography and high-resolution computed tomography in clinical stage IA lung adenocarcinoma.Ann Thorac Surg, 2013, 96(6):1958-1965.
23. Chun EJ, Lee HJ, Kang WJ, et al.Differentiation between malignancy and inflammation in pulmonary ground-glass nodules:The feasibility of integrated 18F-FDG PET/CT.Lung Cancer, 2009, 65(2):180-186.
24. Ichinose J, Kohno T, Fujimori S, et al.Invasiveness and malignant potential of pulmonary lesions presenting as pure ground-glass opacities.Ann Thorac Cardiovas Surg, 2014, 20(5):347-352.
25. Sakata I, Ozeki Y, Tamura K, et al.A case of early stage lung cancer detected by repeated cancer screening with positron emission tomography.Oncol Lett, 2012, 3(2):297-299.
26. 張麗萍, 陳成水.肺部單發磨玻璃樣結節的最新研究進展.醫學研究雜志, 2011, 40(2):13-15, 2.
27. 郭峰, 張志庸, 崔玉尚, 等.肺局限性磨玻璃樣病灶的外科處理.中國肺癌雜志, 2008, 11(5):739-741.
28. 虞桂平, 黃斌, 陳國強, 等.電視胸腔鏡在肺部局限性磨玻璃樣病灶手術中的應用.江蘇醫藥, 2012, 38(22):2768-2768.
29. 潘小杰, 郭天興, 葉明凡, 等.胸腔鏡手術聯合PET/CT診療44例肺磨玻璃樣病變臨床分析.腫瘤防治研究, 2013, 40(7):706-708.
30. Yan TD, Black D, Bannon PG, et al.Systematic review and meta-analysis of randomized and nonrandomized trials on safety and efficacy of video-assisted thoracic surgery lobectomy for early-stage non-small-cell lung cancer.J Clin Oncol, 2009, 27(15):2553-2562.
31. Kohno T, Fujimori S, Kishi K, et al.Safe and effective minimally invasive approaches for small ground glass opacity.Ann Thorac Surg, 2010, 89(6):S2114-S2117.
32. Tsutani Y, Miyata Y, Nakayama HA, et al.Prediction of pathologic node-negative clinical stage IA lung adenocarcinoma for optimal candidates undergoing sublobar resection.J Thorac Cardiovasc Surg, 2012, 144(6):1365-1371.
33. 魏立, 趙松, 陳明耀, 等.精確CT引導定位局限性肺磨玻璃影的臨床病理和手術模式探討.實用醫學雜志, 2012, 28(22):3723-3725.
34. Tsutani Y, Miyata Y, Nakayama H, et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma.Chest, 2014, 145(1):66-71.
35. Sugi K, Kobayashi S, Sudou M, et al.Long-term prognosis of video-assisted limited surgery for early lung cancer.Eur J Cardio-Thorac Surg, 2010, 37(2):456-460.
36. Yoshida J, Nagai K, Yokose T, et al.Limited resection trial for pulmonary ground-glass opacity nodules:fifty-case experience.J Thorac Cardiovasc Surg, 2005, 129(5):991-996.
37. Matsuguma H, Nakahara R, Anraku M, et al.Objective definition and measurement method of ground-glass opacity for planning limited resection in patients with clinical stage IA adenocarcinoma of the lung.Euro J Cardio-Thorac Surg, 2004, 25(6):1102-1105.
38. Ohtsuka T, Watanabe KI, Kaji M, et al.A clinicopathological study of resected putmonary nodules with focal pure ground-glass opacity.Euro J Cardio-Thorac Surg, 2006, 30(1):160-163.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Pulmonary Ground-glass Opacity

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