Molecular biological research progress of non-coding RNAs modulating osteoarthritis_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

JIA Di ,  LI Yanlin , WANG Kun , CAI Guofeng , YANG Lingjian , MENG Xuhan

Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000, P.R.China;

Corresponding?author：

LI Yanlin, Email: 852387873@qq.com

Keywords：

Non-coding RNA; osteoarthritis; molecular biology

DOI：

10.7507/1002-1892.201610123

Video：

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Objective To summarize the molecular biological research progress of non-coding RNAs modulating osteoarthritis (OA), and provide a reference basis for biological study and clinical treatment of OA. Methods Recent domestic and foreign related literature about the regulation of OA pathological process by non-coding RNAs was widely reviewed. Results Non-coding RNAs can be divided into three types based on the length of RNA. A lot of non-coding RNAs participating in OA pathological process are screened out by high throughput sequencing technology and microarray technology, and it is verified that these non-coding RNAs involve in the regulation of OA by RT-PCR. The mechanism of OA mediated target is clarified by knocking-down and overexpressing of the most prominent expressed non-coding RNAs in OA. There are the complicated gene expressed network topology in non-coding RNAs, and between non-coding RNAs and coding RNAs. It provides a basis for clearing the effect of gene structure and function, and finding the definite therapeutic target of OA. Conclusion There is preliminary study on molecular biological mechanism of non-coding RNAs mediating OA, but the key structure or sequence of non-coding RNAs, formation and interaction of effecting composite structure about mediating OA are unknown, and it needs further study.

Citation： JIA Di, LI Yanlin, WANG Kun, CAI Guofeng, YANG Lingjian, MENG Xuhan. Molecular biological research progress of non-coding RNAs modulating osteoarthritis. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(3): 374-378. doi: 10.7507/1002-1892.201610123 Copy

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29.	Nakamura A, Rampersaud YR, Sharma A,et al. Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration. JCI Insight, 2016, 1(12): e86820.
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31.	Song J, Ahn C, Chun CH,et al. A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis. J Orthop Res, 2014, 32(12): 1628-1635.

1. Deng B, Wang F, Yin L,et al. Quantitative study on morphology of calcified cartilage zone in OARSI 04 cartilage from osteoarthritic knees. Curr Res Transl Med, 2016, 64(3): 149-154.
2. Fraysse F, Arnold J, Thewlis D. A method for concise reporting of joint reaction forces orientation during gait. J Biomech, 2016, 49(14): 3538-3542.
3. Bode G, Kloos F, Feucht MJ,et al. Comparison of the efficiency of an extra-articular absorber system and high tibial osteotomy for unloading the medial knee compartment: anin vitro study. Knee Surg Sports Traumatol Arthrosc, 2016.[Epub ahead of print].
4. Morgan TK, Jensen E, Lim J,et al. Image-guided hyaluronic acid injection and knee bracing significantly improve clinical outcomes for high-grade osteoarthritis. Sports Med Open, 2015, 1(1): 31.
5. Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet, 2006, 15(1): R17-R29.
6. Naomichi T, Kunihiro O. Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment. RNA Biol, 2016, 20: 1-5.
7. Yang K, Gao Y, Yang M,et al. Creating conditional dual fluorescence labeled transgenic animals for studying function of small noncoding RNAs. Connect Tissue Res, 2016.[Epub ahead of head].
8. Necsulea A, Soumillon M, Warnefors M. The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature, 2014, 505(7485): 635-640.
9. Chen G, Wang Z, Wang D,et al. LncRNADisease: a database for long-non-coding RNA-associated diseases. Nuc Aci Res, 2013, 41(Databaseissue): D983-D986.
10. Suzuki T, Hasso SM, Fallon JF. Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity. Proc Natl Acad Sci U S A, 2008, 105(11): 4185-4190.
11. Chimal-Monroy J, Rodriguez-Leon J, Montero JA,et al. Analysis of the molecular cascade responsible for mesodermal limb chondrogenesis: sox genes and BMP signaling. Dev Biol, 2003, 257(2): 292-301.
12. Lehmann K, Seemann P, Stricker S,et al. Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci U S A, 2003, 100(21): 12277-12282.
13. Fu M, Huang G, Zhang Z,et al. Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients. Osteoarthritis Cartilage, 2015, 23(3): 423-432.
14. Carthew RW, Sontheimer EJ, Carthew RW. Origins and Mechanisms of miRNA and siRNA. Cell, 2009, 136: 642-655.
15. Guzzi PH, Di Martino MT, Tagliaferri P,et al. Analysis of miRNA, mRNA, and TF interactions through network-based methods. EURASIP Journal on Bioinformatics and Systems Biology, 2015, 2015: 1-11.
16. Anokye-Danso F, Trivedi CM, Juhr D,et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell, 2011, 8(4): 376-388.
17. Tomankova T, Petrek M, Gallo J,et al. MicroRANs: Emerging regulates of immune-mediated diseases. Scand J Immunol, 2012, 75(2): 129-141.
18. Kostopoulou F, Malizos KN, Papathanasiou I,et al. MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes. Arthritis Res Ther, 2015, 17: 42.
19. Tardif G, Hum D, Pelletier JP,et al. Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord, 2009, 10: 148.
20. Li X, Gibson G, Kim JS,et al. MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene, 2011, 480(1-2): 34-41.
21. Park KW, Lee KM, Yoon DS,et al. Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1. Osteoarthritis Cartilage, 2016, 24(12): 2153-2161.
22. Mátrai J, Chuah MK, Vanden Driessche T. Recent advances in lentiviral vector development and applicantions. Mol Ther, 2010, 18(3): 477-490.
23. 寧仁德, 孔令超, 周業金, 等. 慢病毒介導siRNA沉默ERK2對創傷性骨性關節炎大鼠軟骨退變的影響及其機制. 山東醫藥, 2016, 56(16): 1-4.
24. Hansen TB, Jensen TI, Clausen BH,et al. Natural RNA circles function as efficient microRNA sponges. Nature, 2013, 495(7441): 384-388.
25. Memczak S, Jens M, Elefsinioti A,et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature, 2013, 495(7441): 333-338.
26. Liu Q, Zhang X, Hu X,et al. Circular RNA related to the chondrocyte ECM regulates MMP13 expression by functioning as a MiR-136‘Sponge’ in human cartilage degradation. Sci Rep, 2016, 6: 22572.
27. Jalali S, Bhartiya D, Lalwani MK,et al. Systematic transcriptome wide analysis of lncRNA-miRNA interactions. PLoS One, 2013, 8(2): e5382.
28. Rogler LE, Kosmyna B, Moskowitz D,et al. Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia. Hum Mol Genet, 2014, 23(2): 368-382.
29. Nakamura A, Rampersaud YR, Sharma A,et al. Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration. JCI Insight, 2016, 1(12): e86820.
30. Liu MX, Chen X, Chen G,et al. A computational framework to infer human disease-associated long noncoding RNAs. PLoS One, 2014, 9(1): e84408.
31. Song J, Ahn C, Chun CH,et al. A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis. J Orthop Res, 2014, 32(12): 1628-1635.

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