片仔癀聯合多西他賽對舌鱗狀細胞癌細胞生長及凋亡的影響_West China Medical Journal

Authors：

王丹 ¹ ,  張忠提 ² , 王振華 ¹

1. ;
2. ;

Corresponding?author：

張忠提, Email: zhangzhongti@163.com

Keywords：

片仔癀; 多西他賽; 舌鱗狀細胞癌; 細胞生長; 細胞凋亡

DOI：

10.7507/1002-0179.201704054

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的探討片仔癀聯合多西他賽對舌鱗狀細胞癌（鱗癌）Tca8113 細胞生長、凋亡及細胞周期的影響。方法取對數生長期 Tca8113 細胞，設對照組、片仔癀單藥組（450 μg/mL）、多西他賽單藥組（0.01 μg/L）及聯合用藥組，培養 48 h 后，應用碘化丙啶（propidium iodide，PI）染色檢測藥物對 Tca8113 細胞周期的影響，應用流式細胞儀檢測細胞的凋亡情況。結果 PI 染色結果顯示片仔癀與多西他賽聯合用藥可阻滯細胞于 G₀/G₁ 期和 G₂/M 期，且與對照組及各單藥組相比 S 期細胞的下降比例顯著降低（P<0.01）。AnnexinV/PI 雙染試驗結果顯示聯合用藥組與對照組及各單藥組相比，細胞凋亡比例顯著升高（P<0.01）。結論片仔癀與多西他賽聯合應用可抑制舌鱗癌細胞生長并促進細胞凋亡。

Citation： 王丹, 張忠提, 王振華. 片仔癀聯合多西他賽對舌鱗狀細胞癌細胞生長及凋亡的影響. West China Medical Journal, 2017, 32(6): 880-882. doi: 10.7507/1002-0179.201704054 Copy

1.	張陳平. 關于舌癌治療的幾點建議. 中國實用口腔科雜志, 2010, 3(7): 385-387.
2.	Takácsi-Nagy Z, Hitre E, Remenár é, et al. Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage Ⅲ-Ⅳ unresectable head and neck cancer: Results of a randomized phase Ⅱ study. Strahlenther Onkol, 2015, 191(8): 635-641.
3.	Van Der Veldt AA, Lubberink M, Mathijssen RH, et al. Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C] docetaxel and positron emission tomography. Clin Cancer Res, 2013, 19(15): 4163-4173.
4.	王興遠, 江波, 李程, 等. 多西他賽聯合拓撲替康治療晚期胃癌的臨床觀察. 華西醫學, 2009, 24(9): 2336-2337.
5.	Lü L, Wai MS, Yew DT, et al. Pien Tze huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells. Int J Neurosci, 2009, 119(2): 255-262.
6.	Zhuang Q, Hong F, Shen A, et al. Pien Tze huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol, 2012, 40(5): 1569-1574.
7.	Fu Y, Zhang L, Hong Z, et al. Methanolic extract of Pien Tze huang induces apoptosis signaling in human osteosarcoma MG63 cells via multiple pathways. Molecules, 2016, 21(3): 283.
8.	Lin J, Feng J, Jin Y, et al. Pien Tze huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncol Rep, 2016, 36(6): 3568-3576.
9.	He F, Wu HN, Cai MY, et al. Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. Oncol Lett, 2014, 7(6): 2047-2052.
10.	Shen A, Chen Y, Hong F, et al. Pien Tze huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncol Rep, 2012, 28(6): 2125-2130.
11.	Motonaga M, Yamamoto N, Makino Y, et al. Phase Ⅰ dose-finding and pharmacokinetic study of docetaxel and gefitinib in patients with advanced or metastatic non-small-cell lung cancer: evaluation of drug-drug interaction. Cancer Chemother Pharmacol, 2015, 76(4): 713-721.

1. 張陳平. 關于舌癌治療的幾點建議. 中國實用口腔科雜志, 2010, 3(7): 385-387.
2. Takácsi-Nagy Z, Hitre E, Remenár é, et al. Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage Ⅲ-Ⅳ unresectable head and neck cancer: Results of a randomized phase Ⅱ study. Strahlenther Onkol, 2015, 191(8): 635-641.
3. Van Der Veldt AA, Lubberink M, Mathijssen RH, et al. Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C] docetaxel and positron emission tomography. Clin Cancer Res, 2013, 19(15): 4163-4173.
4. 王興遠, 江波, 李程, 等. 多西他賽聯合拓撲替康治療晚期胃癌的臨床觀察. 華西醫學, 2009, 24(9): 2336-2337.
5. Lü L, Wai MS, Yew DT, et al. Pien Tze huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells. Int J Neurosci, 2009, 119(2): 255-262.
6. Zhuang Q, Hong F, Shen A, et al. Pien Tze huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol, 2012, 40(5): 1569-1574.
7. Fu Y, Zhang L, Hong Z, et al. Methanolic extract of Pien Tze huang induces apoptosis signaling in human osteosarcoma MG63 cells via multiple pathways. Molecules, 2016, 21(3): 283.
8. Lin J, Feng J, Jin Y, et al. Pien Tze huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncol Rep, 2016, 36(6): 3568-3576.
9. He F, Wu HN, Cai MY, et al. Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. Oncol Lett, 2014, 7(6): 2047-2052.
10. Shen A, Chen Y, Hong F, et al. Pien Tze huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncol Rep, 2012, 28(6): 2125-2130.
11. Motonaga M, Yamamoto N, Makino Y, et al. Phase Ⅰ dose-finding and pharmacokinetic study of docetaxel and gefitinib in patients with advanced or metastatic non-small-cell lung cancer: evaluation of drug-drug interaction. Cancer Chemother Pharmacol, 2015, 76(4): 713-721.

Previous Article
Investigation on the awareness of diabetes complications in outpatients with diabetes
Next Article
合并 2 型糖尿病對晚期結直腸癌患者疾病無進展生存時間的影響

West China Medical Journal

片仔癀聯合多西他賽對舌鱗狀細胞癌細胞生長及凋亡的影響

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content