Short-term Effect of Arthroscopic Microfracture Surgery Combined with Oral Glucosamine Hydrochloride in the Treatment of Early Knee Osteoarthritis_West China Medical Journal

Authors：

 DuanXin , LiZhili , ChenZhichao , GuZuchao , LiJianhua , HuJianghai

Department of Orthopedics, the First People's Hospital of Chengdu, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

Keywords：

Osteoarthritis,knee; Microfracture; Glucosamine hydrochloride

DOI：

10.7507/1002-0179.201600326

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Objective To investigate the clinical effect of arthroscopic microfracture surgery combined with oral glucosamine hydrochloride in the treatment of early knee osteoarthritis. Methods We retrospectively analyzed the clinical data of 172 patients with knee osteoarthritis treated between March 2007 and August 2013. The patients were divided into observation group (n=82) and control group (n=90) according to their treatment. Patients in the control group only underwent arthroscopic debridement and cartilage defect microfracture surgery, while those in the observation group underwent arthroscopic microfracture surgery combined with oral glucosamine hydrochloride. The Lysholm knee functional scores, the Lequesne index and X ray image were used to compare the clinical efficacy between the two groups. Results The postoperative symptoms of both the two groups were significantly alleviated. The Lequesne index was not significantly different between the two groups before surgery, and 1 and 3 months after surgery (P>0.05), but it was significantly difference between the two groups 6, 12, 18 and 24 months after surgery (P<0.05). Before surgery, the Lysholm score was not significantly different between the two groups (P>0.05), and the score increased significantly after surgery in both the two groups (P<0.05). One and 3 months after surgery, the Lysholm score was not significantly different between the two groups (P>0.05), but it was significantly higher in the observation group 6, 12, 18 and 24 months after surgery. Conclusion Arthroscopic microfracture surgery combined with oral glucosamine hydrochloride is effective in treating patients with early knee osteoarthritis, and the clinical efficacy becomes more significant with the time of treatment.

Citation： DuanXin, LiZhili, ChenZhichao, GuZuchao, LiJianhua, HuJianghai. Short-term Effect of Arthroscopic Microfracture Surgery Combined with Oral Glucosamine Hydrochloride in the Treatment of Early Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1196-1199. doi: 10.7507/1002-0179.201600326 Copy

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7.	Behery O, Siston RA, Harris JD, et al. Treatment of cartilage defects of the knee[J]. Clin J Sport Med, 2014, 24(1):21-30.
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12.	張晶, 蘇江, 陳棲棲, 等. 自我行為管理聯合鹽酸氨基葡萄糖治療早期膝骨關節炎的療效評估[J]. 華西醫學, 2016, 31(5):803-807.
13.	Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis:a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib[J]. Ann Rheum Dis, 2016, 75(1):37-44.
14.	Salazar J, Bello L, Chávez M, et al. Glucosamine for osteoarthritis:biological effects, clinical efficacy, and safety on glucose metabolism[J]. Arthritis, 2014, 2014:432463.
15.	Terry DE, Rees-Milton K, Pruss C, et al. Modulation of articular chondrocyte proliferation and anionic glycoconjugate synthesis by glucosamine (GlcN), N-acetyl GlcN (GlcNAc) GlcN sulfate salt (GlcN.S) and covalent glucosamine sulfates (GlcN-SO4)[J]. Osteoarthritis Cartilage, 2007, 15(8):946-956.

1. 沈梓維, 林子洪, 鄭秋堅. 膝關節骨關節炎的非手術治療現狀[J]. 中華骨科雜志, 2015, 35(7):774-780.
2. 中華醫學會骨科學分會. 骨關節炎診治指南(2007年版)[J]. 中華骨科雜志, 2007, 27(10):793-796.
3. 魏增永. 關節鏡下微骨折術及其進展[J]. 醫學綜述, 2011, 17(18):2784-2785.
4. Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol Suppl, 1991, 27:16-18.
5. Blevins FT, Steadman JR, Rodrigo JJ, et al. Treatment of articular cartilage defects in athletes:an analysis of functional outcome and lesion appearance[J]. Orthopedics, 1998, 21(7):761-767.
6. Gobbi AK, Kumar A. Long-term results after microfracture treatment for full-thickness knee chondral lesions in athletes[J]. Knee Surg Sports Traumatol Arthrosc, 2014, 22(9):1986-1996.
7. Behery O, Siston RA, Harris JD, et al. Treatment of cartilage defects of the knee[J]. Clin J Sport Med, 2014, 24(1):21-30.
8. Dahmer S, Schiller RM. Glucosamine[J]. Am Fam Physician, 2008, 78(4):471-476.
9. Cibere J, Kopec JA, Thorne A, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis[J]. Arthritis Rheum, 2004, 51(5):738-745.
10. Wu D, Huang Y, Gu Y, et al. Efficacies of different preparations of glucosamine for the treatment of osteoarthritis:a meta-analysis of randomised, double-blind, placebo-controlled trials[J]. Int J Clin Pract, 2013, 67(6):585-594.
11. Hiyama Y, Yamada M, Kitagawa A, et al. A four-week walking exercise programme in patients with knee osteoarthritis improves the ability of dual-task performance:a randomized controlled trial[J]. Clin Rehabil, 2012, 26(5):403-412.
12. 張晶, 蘇江, 陳棲棲, 等. 自我行為管理聯合鹽酸氨基葡萄糖治療早期膝骨關節炎的療效評估[J]. 華西醫學, 2016, 31(5):803-807.
13. Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis:a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib[J]. Ann Rheum Dis, 2016, 75(1):37-44.
14. Salazar J, Bello L, Chávez M, et al. Glucosamine for osteoarthritis:biological effects, clinical efficacy, and safety on glucose metabolism[J]. Arthritis, 2014, 2014:432463.
15. Terry DE, Rees-Milton K, Pruss C, et al. Modulation of articular chondrocyte proliferation and anionic glycoconjugate synthesis by glucosamine (GlcN), N-acetyl GlcN (GlcNAc) GlcN sulfate salt (GlcN.S) and covalent glucosamine sulfates (GlcN-SO4)[J]. Osteoarthritis Cartilage, 2007, 15(8):946-956.

West China Medical Journal

Short-term Effect of Arthroscopic Microfracture Surgery Combined with Oral Glucosamine Hydrochloride in the Treatment of Early Knee Osteoarthritis

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