Observation of the Clinical Curative Effect of Arthroscopic Debridement Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis_West China Medical Journal

Authors：

 MaoXianfa , ZhuLijun , LiHong , SongXiaoyan

Department of Orthopedics, People's Hospital of Wenjiang District, Chengdu, Sichuan 611130, P. R. China;

Corresponding?author：

Keywords：

Osteoarthritis,knee; Arthroscopic debridement; Glucosamine hydrochloride

DOI：

10.7507/1002-0179.201600325

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Objective To investigate the effect of arthroscopic debridement combined with oral glucosamine hydrochloride tablets in the treatment of knee osteoarthritis. Methods Sixty-two patients with knee osteoarthritis treated between January 2013 and April 2015 were chosen to be our research subjects. They were randomly divided into trial group (n=31) and control group (n=31). The control group was treated with arthroscopic debridement, and the trial group was given glucosamine hydrochloride tablets for treatment, apart from arthroscopic debridement. We evaluated the clinical effects by visual analogue scale (VAS) score and Lysholm knee joint function score before, and 1 week, 4 weeks, 3 months and 6 months after surgery. Results One week after surgery, the VAS score and Lysholm knee joint function score were not significantly different between the two groups (P>0.05). Four weeks, 3 months and 6 months after surgery, the VAS score of the trial group was respectively 3.08±0.91, 2.46±0.87, and 1.45±0.66, and was 5.47±1.02, 3.55±1.20, and 2.37±0.53 in the control group; the Lysholm score of the trial group was 80.55±2.24, 85.35±1.79, and 89.74±4.58, respectively, and of the control group was 72.55±4.47, 74.68±2.94, and 76.69±5.63. The VAS score and the Lysholm score of the trial group were both better than those of the control group (P<0.05). Conclusion Arthroscopic debridement can alleviate the symptoms of knee osteoarthritis, and oral administration of glucosamine hydrochloride tablets after surgery has obvious effects.

Citation： MaoXianfa, ZhuLijun, LiHong, SongXiaoyan. Observation of the Clinical Curative Effect of Arthroscopic Debridement Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1193-1195. doi: 10.7507/1002-0179.201600325 Copy

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12.	蘇江, 張晶, 吳侗, 等. 鹽酸氨基葡萄糖治療膝關節炎的隨機對照研究[J]. 華西醫學, 2012, 27(12):1776-1779.
13.	Towheed TE, Anastassiades TP, Shea B, et al. Glucosamine therapy for treating osteoarthritis[J]. Cochrane Database Syst Rev, 2001(1):CD002946.
14.	春潔, 賈源源, 張琦, 等. 鹽酸氨基葡萄糖片聯合玻璃酸鈉治療顳下頜關節骨關節炎的臨床隨機對照實驗[J]. 華西口腔醫學雜志, 2011, 29(6):632-639.

1. 柳學勇, 冉春風, 劉盼, 等. 低強度聚焦超聲與普通超聲治療創傷性膝關節炎的療效比較[J]. 中華物理醫學與康復雜志, 2011, 33(12):927-929.
2. 何勇, 肖漣波, 翟偉韜, 等. 基于MRI滑膜測量的關節鏡滑膜切除術治療膝類風濕關節炎療效分析[J]. 中國矯形外科雜志, 2014, 22(18):1651-1656.
3. Losina E, Burbine SA, Suter LG. Pharmacologic regimens for knee osteoarthritis prevention:can they be cost-effective?[J]. Osteoarthritis Cartilage, 2014, 22(3):415-430.
4. 譚靜雅, 楊南萍. 骨關節炎的發病機制及診治的研究進展[J]. 華西醫學, 2012, 27(12):1828-1832.
5. 蔣禮源, 黃頌安. 關節鏡下清理術聯合玻璃酸鈉治療膝關節骨性關節炎55例[J]. 廣西醫學, 2012, 34(9):1220-1221.
6. Cooper MT, Miller MD.Primary articular cartilage procedures in the middle-aged Knee[J]. Sports Med Arthrosc Rev, 2003, 11(5):112-121.
7. Steadman JR, Briggs KK, Rodrigo JJ. Outcomes of microfracture for traumatic chondral of the knee:averge 11-year follow-up[J].Arthroscopy, 2003, 19(5):477-484.
8. Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucousamine hydrochloride on the production of prostaglandin E2, nitric oxide and metallogroteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3):293-299.
9. 何文革, 閆冬梅, 李瑞陽, 等. 膝關節滑膜炎關節鏡術后口服鹽酸氨基葡萄糖的療效[J]. 2015, 43(2):186-189.
10. Wise BL, Niu J, Zhang Y. The association of parity with osteoarthritis and knee replacement in the multicenter osteoarthritis study[J]. Osteoarthritis Cartilage, 2013, 21(12):1849-1854.
11. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on osteoarthritis progression:a meta-analysis[J]. Rheumatol Int, 2010, 30(3):357-363.
12. 蘇江, 張晶, 吳侗, 等. 鹽酸氨基葡萄糖治療膝關節炎的隨機對照研究[J]. 華西醫學, 2012, 27(12):1776-1779.
13. Towheed TE, Anastassiades TP, Shea B, et al. Glucosamine therapy for treating osteoarthritis[J]. Cochrane Database Syst Rev, 2001(1):CD002946.
14. 春潔, 賈源源, 張琦, 等. 鹽酸氨基葡萄糖片聯合玻璃酸鈉治療顳下頜關節骨關節炎的臨床隨機對照實驗[J]. 華西口腔醫學雜志, 2011, 29(6):632-639.

West China Medical Journal

Observation of the Clinical Curative Effect of Arthroscopic Debridement Combined with Glucosamine Hydrochloride Tablets in the Treatment of Knee Osteoarthritis

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