Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis_West China Medical Journal

Authors：

 CenYi ¹ , YanGuangjian ² ,  WangChuan'en ²

1. Emergency Department, Sport Hospital Attached to Chengdu Sport Institute, Chengdu, Sichuan 610041, P. R. China;
2. Department of Spinal Surgery, Sport Hospital Attached to Chengdu Sport Institute, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

WangChuan'en, Email: 420326301@qq.com

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Efficacy; Safety

DOI：

10.7507/1002-0179.201600317

Video：

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Objective To evaluate the efficacy and safety of glucosamine hydrochloride in the treatment of osteoarthritis. Methods A total of 150 patients with osteoarthritis treated between April 2014 and April 2015 were randomly divided into control group and trial group with 75 in each. Patients in the trial group accepted oral glucosamine hydrochloride, while those in the control group were given diclofenac sodium. Lequesne index, total effective rate and the incidence of adverse reactions of both groups were calculated before and 2, 4, 6 and 8 weeks after treatment, and 2 weeks after drug withdrawal. Results In both groups, Lequesne index started to decrease after 2 weeks of treatment (P<0.05), and reached the minimum value at treatment week eight (P<0.05). The Lequesne index 2 weeks after drug withdrawal was still obviously lower than that before treatment (P<0.05). There was no significant differences in the total effective rate at treatment week eight (83.1% for the control group and 80.9% for the trial group) or the total effective rate 2 weeks after drug withdrawal (80.0% for the control group and 79.4% for the trial group) between the control group and the trial group (P>0.05). The incidence of adverse reactions of the trial group (6.7%) was significantly lower than that of the control group (21.3%) (P<0.05). Conclusion Glucosamine hydrochloride is effective and safe in the treatment of osteoarthritis, which is suitable for long-term treatment.

Citation： CenYi, YanGuangjian, WangChuan'en. Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis. West China Medical Journal, 2016, 31(7): 1164-1166. doi: 10.7507/1002-0179.201600317 Copy

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13.	唐進, 楊濤, 熊小江, 等. 鹽酸氨基葡萄糖聯合塞來昔布治療不同程度膝關節骨性關節炎的臨床研究[J]. 現代生物醫學進展, 2015, 15(2):294-297.
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1. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis[J]. Curr Opin Rheumatol, 2010, 22(2):139-143.
2. Cushnaghan J, Dieppe P. Study of 500 patients with limb joint osteoarthritis. I. Analysis by age,sex,and distribution of symptomatic joint sites[J]. Ann Rheum Dis, 1991, 50(1):8-13.
3. 李玉飛. 湖南省中老年膝骨關節炎的流行病學調查研究[D]. 長沙:中南大學, 2013.
4. 譚靜雅, 楊南萍. 骨關節炎的發病機制及其診治的研究進展[J]. 華西醫學, 2012, 27(12):1828-1832.
5. Recht MP, Kramer J, Marcelis S, et al. Abnormalities of articular cartilage in the knee:analysis of available MR techniques[J]. Radiology, 1993, 187(2):473-478.
6. Bliddal H, Christensen RD, Kristensen PK, et al. Glucosamine effectiveness in the treatment of knee osteoarthritis. Presentation of a Cochrane analysis with the perspective on the GAIT trial[J]. Ugeskr Laeger, 2006, 168(50):4405-4409.
7. Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol Suppl, 1991, 27:16-18.
8. Behery O, Siston RA, Harris JD, et al. Treatment of cartilage defects of the knee:expanding on the existing algorithm[J]. Clin J Sport Med, 2014, 24(1):21-30.
9. Salazar J, Bello L, Chávez M, et al. Glucosamine for osteoarthritis:biological effects, clinical efficacy, and safety on glucose metabolism[J]. Arthritis, 2014, 2014:432463.
10. 石曉明, 于占革. 骨關節炎發病機制的研究進展[J]. 中華臨床醫師雜志:電子版, 2013, 12(24):11607-11610.
11. Permuy M, Guede D, López-Pe?a M, et al. Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis[J]. BMC Vet Res, 2014, 10(1):97.
12. 閔華, 蒙珍. 雙氯芬酸鈉聯合鹽酸氨基葡萄糖治療膝骨關節炎60例[J]. 中國藥業, 2013, 22(9):31-32.
13. 唐進, 楊濤, 熊小江, 等. 鹽酸氨基葡萄糖聯合塞來昔布治療不同程度膝關節骨性關節炎的臨床研究[J]. 現代生物醫學進展, 2015, 15(2):294-297.
14. Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003:an evidence based approach to the management of knee osteoarthritis:report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12):1145-1155.

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Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis

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