Clinical Study on the Therapeutic Effect of Glucosamine Hydrochloride in the Treatment of Chronic Lumbago and Backache_West China Medical Journal

Authors：

 ZhaoMian , DengHong , HeGuanlin , LiYang

Department of Orthopedics, the Third People's Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding?author：

Keywords：

Glucosamine hydrochloride; Chronic lumbago and backache; Short-form McGill pain questionnaire

DOI：

10.7507/1002-0179.201600318

Video：

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Objective To investigate the therapeutic effect of glucosamine hydrochloride on chronic lumbago and backache. Methods We selected 328 outpatients with chronic lumbago and backache diagnosed between May 2014 and May 2015, and randomly (with single blind method) divided them into study group (n=172) and control group (n=156). Patients in the control group were treated with ibuprofen and placebo, while those in the study group were treated with ibuprofen and glucosamine hydrochloride. The short-form McGill pain questionnaire (SF-MPQ) was used for investigation at three time points (before the treatment, one month and two months after the treatment). Results The score of SF-MPQ in the study group was 64.34±23.35 before the treatment, 44.04±13.22 one month after the treatment, and 19.87±8.11 two months after the treatment. While in the control group, the results at those three time points were 65.19±24.12, 47.04±11.36, and 54.44±21.39, respectively. There was no obvious difference between the two groups one month after the treatment (P>0.05). The pain was alleviated in both of the two groups one month after the treatment, while the therapeutic effect in the study group was significantly better than that in the control group two months after the treatment (P<0.05). Archenteric complications were found in 3 patients (1.74%) in the study group and 2 (1.28%) in the control group without a significant difference (P>0.05). Conclusion Glucosamine hydrochloride may effectively alleviate the lumbago and backache without any obvious adverse reactions.

Citation： ZhaoMian, DengHong, HeGuanlin, LiYang. Clinical Study on the Therapeutic Effect of Glucosamine Hydrochloride in the Treatment of Chronic Lumbago and Backache. West China Medical Journal, 2016, 31(7): 1167-1169. doi: 10.7507/1002-0179.201600318 Copy

1.	Kelsey JL, White AA 3rd. Epidemiology and impact of low-back pain[J]. Spine (Phila Pa 1976), 1980, 5(2):133-142.
2.	Snook SH. Self-care guidelines for the management of nonspecific low back pain[J]. J Occup Rehabil, 2004, 14(4):243-253.
3.	Frank J, Sinclair S, Hogg-Johnson S, et al. Preventing disability form workrelated low-back pain. New evidence give new hope-if we can just get all the players onside[J]. CMAJ, 1998, 158(12):1625-1631.
4.	Hestbaek L, Leboeuf-Yde C, Manniche C. Low back pain:what is the long-term course? A review of studies of general patient populations[J]. Eur Spine J, 2003, 12(2):149-165.
5.	羅躍嘉. 簡化McGill疼痛分表的臨床應用評價[J]. 中國康復, 1992, 7(2):160-164.
6.	于洪煒. 腰背痛[J]. 社區醫學雜志, 2007, 12(5):21-23.
7.	胡元明, 李春生. 慢性腰背痛X線分析(附120例報告)[J]. 影像診斷與介入放射學, 1996, 5(6):372-375.
8.	詹志剛. 慢性腰背痛病變的相關CT影像分析[J]. 影像診斷與介入放射學, 2006, 15(2):78-81.
9.	呂紅玲, 易紅赤, 毛曉雯. 腰背痛X線檢查的表現特點[J]. 實用醫技雜志, 2015, 22(7):733-735.
10.	麥甘樹. 腰椎間盤退變腰椎小關節退行性骨關節炎和年齡的相關性分析[J]. 河北醫學, 2011, 17(6):796-799.
11.	Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
12.	柳萬國, 唐成林, 孫莉, 等. 腰椎關節突關節骨性關節炎的CT分級及其臨床意義[J]. 中國脊柱脊髓雜志, 2011, 21(12):981-986.
13.	Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
14.	盧鋒, 郭紅衛. 鹽酸氨基葡萄糖對骨關節炎作用機制的初步探討[J]. 衛生研究, 2003, 32(6):594-597.

1. Kelsey JL, White AA 3rd. Epidemiology and impact of low-back pain[J]. Spine (Phila Pa 1976), 1980, 5(2):133-142.
2. Snook SH. Self-care guidelines for the management of nonspecific low back pain[J]. J Occup Rehabil, 2004, 14(4):243-253.
3. Frank J, Sinclair S, Hogg-Johnson S, et al. Preventing disability form workrelated low-back pain. New evidence give new hope-if we can just get all the players onside[J]. CMAJ, 1998, 158(12):1625-1631.
4. Hestbaek L, Leboeuf-Yde C, Manniche C. Low back pain:what is the long-term course? A review of studies of general patient populations[J]. Eur Spine J, 2003, 12(2):149-165.
5. 羅躍嘉. 簡化McGill疼痛分表的臨床應用評價[J]. 中國康復, 1992, 7(2):160-164.
6. 于洪煒. 腰背痛[J]. 社區醫學雜志, 2007, 12(5):21-23.
7. 胡元明, 李春生. 慢性腰背痛X線分析(附120例報告)[J]. 影像診斷與介入放射學, 1996, 5(6):372-375.
8. 詹志剛. 慢性腰背痛病變的相關CT影像分析[J]. 影像診斷與介入放射學, 2006, 15(2):78-81.
9. 呂紅玲, 易紅赤, 毛曉雯. 腰背痛X線檢查的表現特點[J]. 實用醫技雜志, 2015, 22(7):733-735.
10. 麥甘樹. 腰椎間盤退變腰椎小關節退行性骨關節炎和年齡的相關性分析[J]. 河北醫學, 2011, 17(6):796-799.
11. Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
12. 柳萬國, 唐成林, 孫莉, 等. 腰椎關節突關節骨性關節炎的CT分級及其臨床意義[J]. 中國脊柱脊髓雜志, 2011, 21(12):981-986.
13. Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
14. 盧鋒, 郭紅衛. 鹽酸氨基葡萄糖對骨關節炎作用機制的初步探討[J]. 衛生研究, 2003, 32(6):594-597.

West China Medical Journal

Clinical Study on the Therapeutic Effect of Glucosamine Hydrochloride in the Treatment of Chronic Lumbago and Backache

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