Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy_West China Medical Journal

Authors：

 WANGLi-ying , CHENXiao-man , WUYong-yue , CHENJun-qi

Department of Clinical Laboratory, the People's Hospital of Leizhou City, Leizhou, Guangdong 524200, P. R. China;

Corresponding?author：

Keywords：

Hypertensive disorder complicating pregnancy; Cystatin-C; Renal damage; Diagnosis; Clinical value

DOI：

10.7507/1002-0179.20140334

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Objective To investigate the diagnostic value of serum cystatin-C (Cys-C) detection in hypertensive disorder complicating pregnancy patients. Methods A hundred patients with pregnancy induced hypertension (PIH) were chosen as the research object from February 2012 to March 2013, and they were divided into mild group, moderate group and severe group according to the severity of the disease. The other 40 healthy pregnant women were selected as the controls (the control group). We compared the four groups in terms of Cys-C, serum urea nitrogen (BUN) and creatinine level, as well as the positive rate of Cys-C, BUN, and creatinine. Results Cys-C, BUN, and creatinine in the PIH group were significantly higher than those in the control group (P<0.05). Cys-C and creatinine in preeclampsia mild group were significantly higher than those in the control group (P<0.05), but BUN level between the two was not statistically significant (P>0.05). Cys-C, BUN, and creatinine in the PIH moderate and severe groups were significantly higher than those in the control group (P<0.05). The abnormal rate of Cys-C in the PIH mild group was significantly higher than that of Cys-C and creatinine (P<0.05). Conclusion Cys-C, BUN and creatinine can all show renal damage in PIH patients, but the Cys-C value in early diagnosis is better than that of BUN and creatinine. It can be used as a monitoring index of pregnancy-induced hypertension prevention and early treatment.

Citation： WANGLi-ying, CHENXiao-man, WUYong-yue, CHENJun-qi. Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy. West China Medical Journal, 2014, 29(6): 1096-1098. doi: 10.7507/1002-0179.20140334 Copy

1.	蔣亞萍. 妊娠高血壓綜合征患者血清胱抑素C測定的臨床意義[J]. 檢驗醫學與臨床, 2008, 5(7): 432-433.
2.	楊蔚潔, 顧敏娟, 夏洪, 等. 血清胱抑素C診斷早期糖尿病腎病腎損害[J]. 中國臨床醫學, 2008, 15(2): 223-224.
3.	劉碩, 徐東強, 孫麗麗. 胱抑素C、尿素、肌酐在腎臟疾病檢測和診斷中的應用研究[J]. 臨床合理用藥雜志, 2010, 3(24): 11-12.
4.	方穎, 于景云, 王亞男, 等. 血清胱抑素C在妊娠期高血壓早期腎損害中的意義[J]. 實用預防醫學, 2011, 18(6): 1108-1109.
5.	樂杰. 婦產科學[M]. 7版. 北京: 人民衛生出版社, 2008: 128-129.
6.	余秀瓊, 戴玫. 妊娠期高血壓疾病診斷及治療進展[J]. 心血管病學進展, 2012, 33(6): 777-781.
7.	陳朝霞, 王祥珍. 妊娠高血壓疾病患者免疫功能和C-反應蛋白水平變化及其臨床意義[J]. 廣東醫學院學報, 2011, 29(3): 263-265.
8.	安自民, 高紹華. 評價腎功能損害患者中血清胱抑素C測定的臨床價值[J]. 中國中西醫結合腎病雜志, 2009, 10(12): 1102-1103.
9.	全暉. 血清胱抑素C在腎功能損傷中的診斷價值[J]. 四川醫學, 2009, 30(8): 1320-1321.
10.	孫雪榮, 李海峰, 于春冬, 等. Cysc的動態變化對妊高癥的早期預防及臨床診療價值[J]. 中國優生與遺傳雜志, 2011, 19(12): 66-67.
11.	廖小清, 阮珍. 妊娠期高血壓疾病患者血清超敏C-反應蛋白和尿微量白蛋白的檢測意義[J]. 吉林醫學, 2011, 32(21): 4323-4324.
12.	高桂華, 滿冬亮, 蔡晶. 妊娠高血壓綜合征患者血清胱抑素C水平變化及與其他腎功能指標的相關性[J]. 檢驗醫學與臨床, 2011, 8(16): 1976-1977.
13.	向明, 王莉平. 血清8-isoPGF2α、Cys-C及CRP檢測在妊娠期高血壓綜合征診斷中的意義[J]. 國際檢驗醫學雜志, 2012, 33(14): 1677-1678, 1681.
14.	歐陽清, 劉健, 石青峰, 等. 血清胱抑素C及尿微量白蛋白對妊娠期糖尿病患者腎功能評價的臨床意義[J]. 山東醫藥, 2011, 51(28): 29-30.
15.	李毅, 祁成, 袁鵬, 等. 血清胱抑素C在妊娠期高血壓疾病早期腎損傷中的意義[J]. 中國婦幼保健, 2012, 27(15): 2256-2258.

1. 蔣亞萍. 妊娠高血壓綜合征患者血清胱抑素C測定的臨床意義[J]. 檢驗醫學與臨床, 2008, 5(7): 432-433.
2. 楊蔚潔, 顧敏娟, 夏洪, 等. 血清胱抑素C診斷早期糖尿病腎病腎損害[J]. 中國臨床醫學, 2008, 15(2): 223-224.
3. 劉碩, 徐東強, 孫麗麗. 胱抑素C、尿素、肌酐在腎臟疾病檢測和診斷中的應用研究[J]. 臨床合理用藥雜志, 2010, 3(24): 11-12.
4. 方穎, 于景云, 王亞男, 等. 血清胱抑素C在妊娠期高血壓早期腎損害中的意義[J]. 實用預防醫學, 2011, 18(6): 1108-1109.
5. 樂杰. 婦產科學[M]. 7版. 北京: 人民衛生出版社, 2008: 128-129.
6. 余秀瓊, 戴玫. 妊娠期高血壓疾病診斷及治療進展[J]. 心血管病學進展, 2012, 33(6): 777-781.
7. 陳朝霞, 王祥珍. 妊娠高血壓疾病患者免疫功能和C-反應蛋白水平變化及其臨床意義[J]. 廣東醫學院學報, 2011, 29(3): 263-265.
8. 安自民, 高紹華. 評價腎功能損害患者中血清胱抑素C測定的臨床價值[J]. 中國中西醫結合腎病雜志, 2009, 10(12): 1102-1103.
9. 全暉. 血清胱抑素C在腎功能損傷中的診斷價值[J]. 四川醫學, 2009, 30(8): 1320-1321.
10. 孫雪榮, 李海峰, 于春冬, 等. Cysc的動態變化對妊高癥的早期預防及臨床診療價值[J]. 中國優生與遺傳雜志, 2011, 19(12): 66-67.
11. 廖小清, 阮珍. 妊娠期高血壓疾病患者血清超敏C-反應蛋白和尿微量白蛋白的檢測意義[J]. 吉林醫學, 2011, 32(21): 4323-4324.
12. 高桂華, 滿冬亮, 蔡晶. 妊娠高血壓綜合征患者血清胱抑素C水平變化及與其他腎功能指標的相關性[J]. 檢驗醫學與臨床, 2011, 8(16): 1976-1977.
13. 向明, 王莉平. 血清8-isoPGF2α、Cys-C及CRP檢測在妊娠期高血壓綜合征診斷中的意義[J]. 國際檢驗醫學雜志, 2012, 33(14): 1677-1678, 1681.
14. 歐陽清, 劉健, 石青峰, 等. 血清胱抑素C及尿微量白蛋白對妊娠期糖尿病患者腎功能評價的臨床意義[J]. 山東醫藥, 2011, 51(28): 29-30.
15. 李毅, 祁成, 袁鵬, 等. 血清胱抑素C在妊娠期高血壓疾病早期腎損傷中的意義[J]. 中國婦幼保健, 2012, 27(15): 2256-2258.

West China Medical Journal

Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy

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