Meta-analysis on the Association of <i>CYP11B2</i> Gene Polymorphism and Left Ventricular Hypertrophy in Chinese Hypertensive Patients_West China Medical Journal

Authors：

 MABao-xin ¹ , LIUXian-liang ² , LIHua ¹ , LIZong-qing ¹

1. Department of Cardiology, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P. R. China;
2. Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P. R. China;

Corresponding?author：

Keywords：

Hypertension; Left ventricular hypertrophy; Aldosterone synthase; Gene polymorphism; Meta-analysis

DOI：

10.7507/1002-0179.20140074

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Objective To investigate the association between CYP11B2 gene polymorphism and left ventricular hypertrophy in Chinese hypertensive patients by the means of meta-analysis. Methods Literatures about case control study on the association of CYP11B2 gene polymorphism and left ventricular hypertrophy were searched from January 1980 to December 2012.The electronic databases searched included China national knowledge internet,Chinese biological medicine disk,Vip fulltext database,Wanfang fulltext database and Pubmed.Odds ratio (OR) of CYP11B2 genotype distributions in left ventricular hypertrophy (LVH) patients against NLVH patients were analyzed.RevMan 5.1 software was applied for investigating heterogeneity among individual studies and summarizing effects across studies by proper statistical methods. Results Six case-control studies were selected finally.A total of 1 791 hypertensive patients were included.The pooled OR (95% CI) of CC vs.TT+TC genotype was 1.21(0.80,1.81)(Z=0.91,P=0.36),the pooled OR (95% CI) of (TC+CC) vs.TT genotype was 1.16(0.68,1.98)(Z=0.54,P=0.59),and the pooled OR (95% CI) of C vs.T allele was 1.09(0.78,1.54)(Z=0.51,P=0.61). Conclusion The genotype of CYP11B2 polymorphism is not associated with an increase risk of left ventricular hypertrophy in Chinese hypertensive patients.

Citation： MABao-xin, LIUXian-liang, LIHua, LIZong-qing. Meta-analysis on the Association of CYP11B2 Gene Polymorphism and Left Ventricular Hypertrophy in Chinese Hypertensive Patients. West China Medical Journal, 2014, 29(2): 239-242. doi: 10.7507/1002-0179.20140074 Copy

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8.	周永,高春香,張瑞志,等.醛固酮合成酶基因多態性(C/T)與高血壓患者左室肥厚相關性研究[J].高血壓雜志,2004,12(4):315-318.
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11.	陳愛華,張文秀,唐曉明,等.醛固酮合成酶基因多態性與高血壓及左室肥厚的關系[J].中華內科雜志,2002,41(5):298-301.
12.	鄒茜婷,安振梅.醛固酮對心血管系統的不良影響與治療[J].華西醫學,2007,22(3):551-552.
13.	鄧玨琳,高云,黃德嘉,等.原發性高血壓與血管緊張素轉換酶基因多態性的相關性研究[J].華西醫學,2000,15(2):164-166.
14.	楊靜,張泉,李江津,等.中國漢族人群醛固酮合成酶CYP11B2基因多態性與原發性高血壓相關性的薈萃分析[J].中華高血壓雜志,2011,19(7):673-677.

1. Delles C,Erdmann J,Jacobi J,et al.Aldosterone synthase (CYP11B2)-344C/T polymorphism is associated with left ventricular structure in human arterial hypertension[J].J Am Coll Cardiol,2001,37(3):878-884.
2. Stella P,Bigatti G,Tizzoni L,et al.Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension[J].J Am Coll Cardiol,2004,43(2):265-270.
3. Kupari M,Hautanen A,Lankinen L,et al.Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size,mass,and function[J].Circulation,1998,97(6):569-575.
4. Kurbanova D,Eliseyeva M.Genetic background of left ventricular hypertrophy in Uzbek hypertensive men[J].Turk Kardiyol Dern Ars,2010,38(7):466-472.
5. Isaji M,Mune T,Takada N,et al.Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2[J].J Hypertens,2005,23(6):1149-1157.
6. 崔俊彪,王曦云,盛莉,等.醛固酮合成酶基因-344C/T多態性與高血壓左室肥厚相關性研究[J].中國心血管病研究雜志,2006,4(3):190-193.
7. 孫曉健,劉少榮,劉文波,等.醛固酮合成酶基因-344T/C多態性與高血壓性左室肥厚相關性研究[J].臨床心血管病雜志,2004,20(7):386-388.
8. 周永,高春香,張瑞志,等.醛固酮合成酶基因多態性(C/T)與高血壓患者左室肥厚相關性研究[J].高血壓雜志,2004,12(4):315-318.
9. 陳丹.醛固酮合成酶CYP11B2基因C-344T多態性與原發性高血壓發病關系的研究[D].大連:大連醫科大學,2004:18.
10. 李慶祥.高血壓及其靶器官損害的相關基因研究[D].北京:北京協和醫科大學,2003.
11. 陳愛華,張文秀,唐曉明,等.醛固酮合成酶基因多態性與高血壓及左室肥厚的關系[J].中華內科雜志,2002,41(5):298-301.
12. 鄒茜婷,安振梅.醛固酮對心血管系統的不良影響與治療[J].華西醫學,2007,22(3):551-552.
13. 鄧玨琳,高云,黃德嘉,等.原發性高血壓與血管緊張素轉換酶基因多態性的相關性研究[J].華西醫學,2000,15(2):164-166.
14. 楊靜,張泉,李江津,等.中國漢族人群醛固酮合成酶CYP11B2基因多態性與原發性高血壓相關性的薈萃分析[J].中華高血壓雜志,2011,19(7):673-677.

West China Medical Journal

Meta-analysis on the Association of CYP11B2 Gene Polymorphism and Left Ventricular Hypertrophy in Chinese Hypertensive Patients

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