Relationship between Plasma Homocysteine Level and Intracranial Artery Atherosclerosis in Patients with Cerebral Infarction_West China Medical Journal

Authors：

 GUCheng-wu , GUOWei-peng , JIANGShi-jie , YUMing

Department of Neurology, Central Hospital of Suining City, Suining, Sichuan 629000, P. R. China;

Corresponding?author：

Keywords：

Homocysteine; Atherosclerosis; Cerebral infarction

DOI：

10.7507/1002-0179.20140063

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Objective To explore the relationship between plasma homocysteine level and intracranial artery atherosclerosis in patients with cerebral infarction. Methods A total of 120 patients with cerebral infarction diagnosed between January and December 2013 were selected.Plasma homocysteine level was analyzed and intracranial artery was detected by DSA. Results Intracranial artery atherosclerosis can be found in most of patients with cerebral infarction.Moreover,Plasma Hcy level of patients with large cerebral artery atherosclerosis was much higher than others (P<0.05).The much higher Plasma Hcy level,the severe intracranial artery atherosclerosis were found in internal carotid artery and cerebral middle artery (P<0.05). Conclusion Intracranial artery atherosclerosis is common in patients with cerebral infarction.Occurrence of intracranial artery atherosclerosis is positively correlated with plasma homocysteine level.Plasma homocysteine level may be a risk factor of intracranial artery atherosclerosis in patients with cerebral infarction.

Citation： GUCheng-wu, GUOWei-peng, JIANGShi-jie, YUMing. Relationship between Plasma Homocysteine Level and Intracranial Artery Atherosclerosis in Patients with Cerebral Infarction. West China Medical Journal, 2014, 29(2): 207-209. doi: 10.7507/1002-0179.20140063 Copy

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11.	Tan NC,Venketasubramanian N,Saw SM,et al.Hyperhomocyst (e) inemia and risk of ischemic stroke among young Asian adults[J].Stroke,2002,33(8):1956-1962.
12.	王桂紅,王擁軍,何耀,等.血漿同型半胱氨酸水平與腦大動脈粥樣硬化性病變的相關性分析[J].中華內科雜志,2006,45(9):744-747.
13.	Sen S,Hinderliter A,Sen PK,et al.Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attack[J].Circulation,2007,116(8):928-935.
14.	Wald DS,Wald NJ,Morris JK,et al.Folic acid,homocysteine,and cardiovascular disease:judging causality in the face of inconclusive trial evidence[J].BMJ,2006,333(7578):1114-1117.
15.	王普清,羅韻文,張貴斌,等.進展性腦梗死危險因素Logistic回歸分析[J].卒中與神經疾病,2007,14(6):368-372.
16.	Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease and stroke:a meta-analysis[J].JAMA,2002,288(16):2015-2022.

1. 高晶,郭玉璞,趙慶杰,等.顱內動脈粥樣硬化的分布及炎性因素探討[J].中華神經科雜志,2006,39(7):459-462.
2. 易興陽,潘光強,余昌明,等.頸動脈粥樣硬化與腦梗死復發的關系探討[J].中華神經科雜志,2002,35(2):68-70.
3. 顧炳權,王多寧.血漿同型半胱氨酸水平及臨床診斷意義[J].中國血液流變學雜志,2004,14(4):630-634,638.
4. 中華醫學會神經病學分會腦血管病學組缺血性腦卒中二級預防指南撰寫組.中國缺血性腦卒中和短暫性腦缺血發作二級預防指南(2010)[J].中國臨床醫生,2011,2(11):68-74.
5. 淦作松,倪修紅,唐尤佳,等.全腦血管造影術在診斷腦血管病的應用[J].江西醫藥,2008,43(8):834-835.
6. Manninen AL,Isokangas JM,Karttunen A,et al.A comparison of radiation exposure between diagnostic CTA and DSA examinations of cerebral and cervicocerebral vessels[J].AJNR Am J Neuroradiol,2012,33(11):2038-2042.
7. 張志勇,李慎茂,魏嘉平,等.粥樣硬化性顱內-外動脈狹窄與冠狀動脈狹窄的關系[J].中國腦血管病雜志,2007,4(6):241-245.
8. 陳東,智睿,丁朝兵,等.頸動脈粥樣硬化斑塊及其相關因素與腦梗死的關系[J].臨床神經病學雜志,2007,20(6):468-470.
9. 劉文軍,姜萍,張宗權,等.低場磁共振彌散加權成像在急性腦梗死診斷中的應用價值[J].華西醫學,2010,25(8):1499-1501.
10. 劉新通,王偉,王麗娟,等.伴有顱內外動脈狹窄或閉塞的急性腦梗死后側支循環建立與預后的關系[J].中華醫學雜志,2011,91(11):766-768.
11. Tan NC,Venketasubramanian N,Saw SM,et al.Hyperhomocyst (e) inemia and risk of ischemic stroke among young Asian adults[J].Stroke,2002,33(8):1956-1962.
12. 王桂紅,王擁軍,何耀,等.血漿同型半胱氨酸水平與腦大動脈粥樣硬化性病變的相關性分析[J].中華內科雜志,2006,45(9):744-747.
13. Sen S,Hinderliter A,Sen PK,et al.Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attack[J].Circulation,2007,116(8):928-935.
14. Wald DS,Wald NJ,Morris JK,et al.Folic acid,homocysteine,and cardiovascular disease:judging causality in the face of inconclusive trial evidence[J].BMJ,2006,333(7578):1114-1117.
15. 王普清,羅韻文,張貴斌,等.進展性腦梗死危險因素Logistic回歸分析[J].卒中與神經疾病,2007,14(6):368-372.
16. Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease and stroke:a meta-analysis[J].JAMA,2002,288(16):2015-2022.

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Relationship between Plasma Homocysteine Level and Intracranial Artery Atherosclerosis in Patients with Cerebral Infarction

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