Experimental study on temperature dependence of dielectric properties of biological tissues at 2 450 MHz_Journal of Biomedical Engineering

Authors：

LIU Hongxing , CHENG Yanyan , ZHANG Meng , TIAN Zhen ,  NAN Qun

College of Life Science and Chemistry, The Faculty of Environment and Life Science, Beijing University of Technology; Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, P.R.China;

Corresponding?author：

NAN Qun, Email: nanqun@bjut.edu.cn

Keywords：

biological tissue; dielectric properties; temperature dependence; dielectric model; thermal ablation

DOI：

10.7507/1001-5515.202005027

Video：

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The temperature dependence of relative permittivity and conductivity of ex-vivo pig liver, lung and heart at 2 450 MHz was studied. The relative permittivity and conductivity of three kinds of biological tissues were measured by the open-end coaxial line method. The dielectric model was fitted according to the principle of least square method. The results showed that the relative permittivity and conductivity of pig liver, pig lung and pig heart decreased with the increase of tissue temperature from 20 to 80 ℃. The relative permittivity and conductivity models of pig liver, pig lung and pig heart were established to reflect the law of dielectric properties of biological tissue changing with temperature and provide a reference for the parameters setting of thermal ablation temperature field.

Citation： LIU Hongxing, CHENG Yanyan, ZHANG Meng, TIAN Zhen, NAN Qun. Experimental study on temperature dependence of dielectric properties of biological tissues at 2 450 MHz. Journal of Biomedical Engineering, 2021, 38(4): 703-708. doi: 10.7507/1001-5515.202005027 Copy

1.	陳凱, 方主亭. 熱消融在肺癌中的應用和展望. 中華介入放射學電子雜志, 2019, 7(2): 126-129.
2.	Gao Xiang, Tian Zhen, Cheng Yanyan, et al. Experimental and numerical study of microwave ablation on ex-vivo porcine lung. Electromagn Biol Med, 2019, 38(4): 249-261.
3.	嵇敏潔, 印佳, 楊悅, 等. 腫瘤熱療無損測溫方法的研究進展. 北京生物醫學工程, 2019, 38(1): 96-101.
4.	羅光彩. 2450 MHz微波消融離體豬肺組織的實驗研究. 山東: 泰山醫學院, 2014.
5.	高翔, 陳仕林, 劉靜紈, 等. 基于CT的兔肺腫瘤微波消融的溫度場研究. 北京生物醫學工程, 2020, 39(4): 372-379.
6.	Carberry G A, Nocerino E, Cristescu M M, et al. Microwave ablation of the lung in a porcine model: vessel diameter predicts pulmonary artery occlusion. Cardiovasc Inter Rad, 2017, 40(10): 1609-1616.
7.	南群, 郭雪梅, 翟飛, 等. 血管對肝臟微波消融溫度場的影響. 北京工業大學學報, 2014, 40(12): 1917-1922.
8.	Cheng Gui, Shi Liangrong, Qiang Weiguang, et al. The safety and efficacy of microwave ablation for the treatment of CRC pulmonary metastases. Int J Hyperther, 2018, 34(4): 486-491.
9.	田甄, 程妍妍, 高翔, 等. 微波消融聯合液體注射的溫度場. 北京工業大學學報, 2020, 46(7): 803-811.
10.	曾海萍, 韓繼鈞, 辛學剛. 生物組織介電特性測量研究進展. 中國醫療設備, 2016, 31(5): 5-11.
11.	趙金哲, 王娟, 沐勇杰, 等. 肝癌微波消融中熱損傷參數分析. 北京生物醫學工程, 2019, 38(4): 392-399.
12.	Fu Fanrui, Xin Xuegang, Chen Wufan. Temperature and frequency-dependent dielectric properties of biological tissues within the temperature and frequency ranges typically used for magnetic resonance imaging-guided focused ultrasound surgery. Int J Hyperther, 2014, 30(1): 56-65.
13.	張立彬, 胥芳, 計時鳴, 等. 蘋果內部品質自動化無損檢測系統的原理與實現(英文). 農業工程學報, 2001, 17(1): 140-145.
14.	陳蕊. 基于動態掃頻介電常數的測量研究. 西安: 西安電子科技大學, 2009.
15.	傅世強, 姜家宏, 李嬋娟. 基于諧振腔微擾理論的電介質測量創新實驗設計. 實驗科學與技術, 2015, 13(5): 25-28.
16.	王秀麗, 陳彥, 賈明全. 介電常數的實地測量裝置的研制. 電子測量技術, 2010, 33(9): 4-7.
17.	La G A, Porter E, Merunka I, et al. Open-ended coaxial probe technique for dielectric measurement of biological tissues: Challenges and common practices. Diagnostics, 2018, 8(2): 40-48.
18.	陳妙良, 陳建國, 魏珊珊, 等. 基于開端同軸射頻組織介電特性測量技術的乳腺癌及癌周組織鑒別檢測實驗研究. 生物醫學工程學雜志, 2016, 33(5): 958-962.
19.	賈曄. 用同軸探針法測量部分生物材料的復介電常數. 真空電子技術, 2011(2): 54-57.
20.	馮健. 生物組織介電特性測量及模擬材料研究. 廣州: 南方醫科大學, 2015.
21.	Trujillo M, Berjano E. Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation. Int J Hyperther, 2013, 29(6): 590-597.
22.	Etoz S, Brace C L. Development of water content dependent tissue dielectric property models. IEEE J Electromagn RF Microw Med Biol, 2019, 3(2): 105-110.
23.	Sebek J, Bortel R, Prakash P. Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models. Med Phys, 2019, 46(10): 4291-4303.
24.	Bobowski J S, Johnson T. Permittivity measurements of biological samples by an open-ended coaxial line. Prog Electromang Res, 2012, 40(2): 159-183.
25.	Gregory A P, Clarke R N. Tables of the complex permittivity of dielectric reference liquids at frequencies up to 5 GHz. Teddington: Nation Physical Laboratory, 2012.
26.	陳曦, 王偉. 基于Matlab的電介質介電常數測量試驗數據處理. 教育教學論壇, 2018, 10(10): 267-268.
27.	呂喜明, 李明遠. 最小二乘法曲線擬合的Matlab實現. 內蒙古民族大學學報, 2009, 24(2): 125-127.
28.	陳軍. 數據的正態性檢驗及Excel/SPSS/Stata軟件的實操應用. 四川職業技術學院學報, 2019, 29(3): 157-161.
29.	劉濤. 水果表面農藥殘留快速檢測方法及模型研究. 南昌: 華東交通大學, 2011.
30.	Liu Dong. Characterization and modeling of tissue contraction during thermal ablation. Madison: University of Wisconsin-Madison, 2016.
31.	Zhen Ji, Christopher L B. Expanded modeling of temperature-dependent dielectric properties for microwave thermal ablation. Phys Med Biol, 2011, 56(10): 5249-5264.
32.	胡昊, 田甄, 南群. 肺腫瘤微波消融治療效果影響因素的研究現狀. 北京生物醫學工程, 2020, 39(6): 643-649.

1. 陳凱, 方主亭. 熱消融在肺癌中的應用和展望. 中華介入放射學電子雜志, 2019, 7(2): 126-129.
2. Gao Xiang, Tian Zhen, Cheng Yanyan, et al. Experimental and numerical study of microwave ablation on ex-vivo porcine lung. Electromagn Biol Med, 2019, 38(4): 249-261.
3. 嵇敏潔, 印佳, 楊悅, 等. 腫瘤熱療無損測溫方法的研究進展. 北京生物醫學工程, 2019, 38(1): 96-101.
4. 羅光彩. 2450 MHz微波消融離體豬肺組織的實驗研究. 山東: 泰山醫學院, 2014.
5. 高翔, 陳仕林, 劉靜紈, 等. 基于CT的兔肺腫瘤微波消融的溫度場研究. 北京生物醫學工程, 2020, 39(4): 372-379.
6. Carberry G A, Nocerino E, Cristescu M M, et al. Microwave ablation of the lung in a porcine model: vessel diameter predicts pulmonary artery occlusion. Cardiovasc Inter Rad, 2017, 40(10): 1609-1616.
7. 南群, 郭雪梅, 翟飛, 等. 血管對肝臟微波消融溫度場的影響. 北京工業大學學報, 2014, 40(12): 1917-1922.
8. Cheng Gui, Shi Liangrong, Qiang Weiguang, et al. The safety and efficacy of microwave ablation for the treatment of CRC pulmonary metastases. Int J Hyperther, 2018, 34(4): 486-491.
9. 田甄, 程妍妍, 高翔, 等. 微波消融聯合液體注射的溫度場. 北京工業大學學報, 2020, 46(7): 803-811.
10. 曾海萍, 韓繼鈞, 辛學剛. 生物組織介電特性測量研究進展. 中國醫療設備, 2016, 31(5): 5-11.
11. 趙金哲, 王娟, 沐勇杰, 等. 肝癌微波消融中熱損傷參數分析. 北京生物醫學工程, 2019, 38(4): 392-399.
12. Fu Fanrui, Xin Xuegang, Chen Wufan. Temperature and frequency-dependent dielectric properties of biological tissues within the temperature and frequency ranges typically used for magnetic resonance imaging-guided focused ultrasound surgery. Int J Hyperther, 2014, 30(1): 56-65.
13. 張立彬, 胥芳, 計時鳴, 等. 蘋果內部品質自動化無損檢測系統的原理與實現(英文). 農業工程學報, 2001, 17(1): 140-145.
14. 陳蕊. 基于動態掃頻介電常數的測量研究. 西安: 西安電子科技大學, 2009.
15. 傅世強, 姜家宏, 李嬋娟. 基于諧振腔微擾理論的電介質測量創新實驗設計. 實驗科學與技術, 2015, 13(5): 25-28.
16. 王秀麗, 陳彥, 賈明全. 介電常數的實地測量裝置的研制. 電子測量技術, 2010, 33(9): 4-7.
17. La G A, Porter E, Merunka I, et al. Open-ended coaxial probe technique for dielectric measurement of biological tissues: Challenges and common practices. Diagnostics, 2018, 8(2): 40-48.
18. 陳妙良, 陳建國, 魏珊珊, 等. 基于開端同軸射頻組織介電特性測量技術的乳腺癌及癌周組織鑒別檢測實驗研究. 生物醫學工程學雜志, 2016, 33(5): 958-962.
19. 賈曄. 用同軸探針法測量部分生物材料的復介電常數. 真空電子技術, 2011(2): 54-57.
20. 馮健. 生物組織介電特性測量及模擬材料研究. 廣州: 南方醫科大學, 2015.
21. Trujillo M, Berjano E. Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation. Int J Hyperther, 2013, 29(6): 590-597.
22. Etoz S, Brace C L. Development of water content dependent tissue dielectric property models. IEEE J Electromagn RF Microw Med Biol, 2019, 3(2): 105-110.
23. Sebek J, Bortel R, Prakash P. Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models. Med Phys, 2019, 46(10): 4291-4303.
24. Bobowski J S, Johnson T. Permittivity measurements of biological samples by an open-ended coaxial line. Prog Electromang Res, 2012, 40(2): 159-183.
25. Gregory A P, Clarke R N. Tables of the complex permittivity of dielectric reference liquids at frequencies up to 5 GHz. Teddington: Nation Physical Laboratory, 2012.
26. 陳曦, 王偉. 基于Matlab的電介質介電常數測量試驗數據處理. 教育教學論壇, 2018, 10(10): 267-268.
27. 呂喜明, 李明遠. 最小二乘法曲線擬合的Matlab實現. 內蒙古民族大學學報, 2009, 24(2): 125-127.
28. 陳軍. 數據的正態性檢驗及Excel/SPSS/Stata軟件的實操應用. 四川職業技術學院學報, 2019, 29(3): 157-161.
29. 劉濤. 水果表面農藥殘留快速檢測方法及模型研究. 南昌: 華東交通大學, 2011.
30. Liu Dong. Characterization and modeling of tissue contraction during thermal ablation. Madison: University of Wisconsin-Madison, 2016.
31. Zhen Ji, Christopher L B. Expanded modeling of temperature-dependent dielectric properties for microwave thermal ablation. Phys Med Biol, 2011, 56(10): 5249-5264.
32. 胡昊, 田甄, 南群. 肺腫瘤微波消融治療效果影響因素的研究現狀. 北京生物醫學工程, 2020, 39(6): 643-649.

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