Utilization of three-dimensional printing technology for repairing skin tissue_Journal of Biomedical Engineering

Authors：

LAM Yuet-wai ^1,2 ,  AO Ningjian ^1,2

1. Department of Biomedical Engineering, Jinan University, Guangzhou 510632, P.R.China;
2. Key Laboratory of Biomaterials, Guangdong Provincial Department of Education, Guangzhou 510632, P.R.China;

Corresponding?author：

Keywords：

three-dimensional printing; wound dressings; tissue engineering skin; fused deposition modeling; three-dimensional bioprinting

DOI：

10.7507/1001-5515.201711045

Video：

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Three-dimensional (3D) printing is a low-cost, high-efficiency production method, which can reduce the current cost and increase the profitability of skin repair material industry nowadays, and develop products with better performance. The 3D printing technology commonly used in the preparation of skin repair materials includes fused deposition molding technology and 3D bioprinting technology. Fused deposition molding technology has the advantages of simple and light equipment, but insufficient material selection. 3D bioprinting technology has more materials to choose from, but the equipment is cumbersome and expensive. In recent years, research on both technologies has focused on the development and application of materials. This article details the principles of fused deposition modeling and 3D bioprinting, research advances in wound dressings and tissue engineering skin production, and future developments in 3D printing on skin tissue repair, including cosmetic restoration and biomimetic tissue engineering. Also, this review prospects the development of 3D printing technology in skin tissue repairment.

Citation： LAM Yuet-wai, AO Ningjian. Utilization of three-dimensional printing technology for repairing skin tissue. Journal of Biomedical Engineering, 2018, 35(5): 805-810. doi: 10.7507/1001-5515.201711045 Copy

1.	于家傲. 皮膚修復材料的發展歷程-理念與技術的融合. 中華損傷與修復雜志, 2011, 6(1): 12-15.
2.	王彤華, 周雄麗, 謝利勤, 等. 濕性敷料在傷口護理中的應用進展. 齊齊哈爾醫學院學報, 2016, 37(24): 3078-3079.
3.	劉公洪, 廖毅. 濕性敷料治療在燒傷創面的應用進展. 西南軍醫, 2012, 14(1): 113-114.
4.	Kamoun E A, Kenawy E S, Chen Xin. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res, 2017, 8(3): 217-233.
5.	Eberlein T, Gerke P, Lorenzc H, et al. Advantages in wound healing by a topical easy to use wound healing lipo-gel for abrasive wounds—Evidence from a randomized, controlled experimental clinical study. Wound Medicine, 2016, 15: 11-19.
6.	馮占錄, 張興宏, 趙燕玲. 濕性治療技術救治26例燒傷病人的體會//第七屆全國燒傷創瘍學術會議論文匯編. 北京: 中國中西醫結合學會燒傷專業委員會, 2002: 107.
7.	陳曉潔, 呂愛鳳, 高晶, 等. 功能敷料的" 傷口濕潤環境愈合”理論與實踐. 生物醫學工程學進展, 2013, 34(1): 31-34.
8.	江敏君, 邱玉友, 廖新芳. 燒傷創面應用濕性愈合療法的效果觀察與成本效益分析. 實用醫學雜志, 2014, 30(15): 2523-2524.
9.	錢程. 殼聚糖纖維醫用敷料的生產及應用. 紡織學報, 2006, 27(11): 100-105.
10.	馬艷紅. 耗材產業:" 增速換擋期”注重動力轉換. 中國醫藥報, 2016-08-04(3).
11.	馬東東, 周玉杰, 路婷婷, 等. 組織工程皮膚研究現狀. 現代生物醫學進展, 2014, 14(6): 1183-1187.
12.	郝文麗, 張平, 吳訓偉. 組織工程皮膚的現狀和展望. 北京生物醫學工程, 2016, 35(1): 94-99.
13.	楊維, 崔占峰. 組織工程皮膚發展現狀. 中國科學: 生命科學, 2015, 45(5): 460-470.
14.	林越威, 曾輝宇, 劉嘯宇, 等. 三維打印技術在人工器官生產上的應用. 生物醫學工程學雜志, 2015, 32(5): 1160-1164.
15.	羅文峰, 楊雪香, 敖寧建. 生物醫用材料的3D打印技術與發展. 材料導報, 2016, 30(7): 81-86.
16.	鄧濱, 歐陽漢斌, 黃文華. 3D打印在醫學領域的應用進展. 中國醫學物理學雜志, 2016, 33(4): 389-392.
17.	魏玉雪, 劉曉秋, 李迪, 等. 3D打印技術在細胞打印方面的應用與發展. 海南醫學, 2017, 28(5): 801-804.
18.	田曉紅, 張彬, 房艷, 等. 大鼠脂肪源性干細胞與三維打印明膠支架的兼容性. 解剖學報, 2017, 48(2): 209-216.
19.	工業和信息化部, 發展改革委, 教育部, 等. 增材制造產業發展行動計劃(2017～2020年). 鑄造設備與工藝, 2018(2): 59-63.
20.	劉鳳珍, 劉明信, 王運華, 等. 3D打印技術在醫學領域中的應用研究進展. 中國材料進展, 2016, 35(5): 381-385.
21.	Stansbury J W, Idacavage M J. 3D printing with polymers: Challenges among expanding options and opportunities. Dent Mater, 2016, 32(1): 54-64.
22.	Kim K, Park J, Suh J H, et al. 3D printing of multiaxial force sensors using carbon nanotube (CNT)/thermoplastic polyurethane (TPU) filaments. Sens Actuators A Phys, 2017, 263: 493-500.
23.	Liu Wei, Wang Daming, Huang Jianghong, et al. Low-temperature deposition manufacturing: A novel and promising rapid prototyping technology for the fabrication of tissue-engineered scaffold. Mater Sci Eng C Mater Biol Appl, 2017, 70(Pt 2): 976-982.
24.	Hung K C, Tseng C S, Dai L G, et al. Water-based polyurethane 3D printed scaffolds with controlled release function for customized cartilage tissue engineering. Biomaterials, 2016, 83: 156-168.
25.	Mohanty S, Sanger K, Heiskanen A, et al. Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching. Mater Sci Eng C Mater Biol Appl, 2016, 61: 180-189.
26.	Muwaffak Z, Goyanes A, Clark V, et al. Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings. Int J Pharm, 2017, 527(1/2): 161-170.
27.	Cheng Y L, Chen F. Preparation and characterization of photocured poly (ε-caprolactone) diacrylate/poly (ethylene glycol) diacrylate/chitosan for photopolymerization-type 3D printing tissue engineering scaffold application. Materials Science and Engineering: C, 2017, 81: 66-73.
28.	Bégin-Drolet A, Dussault M A, Fernandez S A, et al. Design of a 3D printer head for additive manufacturing of sugar glass for tissue engineering applications. Additive Manufacturing, 2017, 15: 29-39.
29.	Munaz A, Vadivelu R K, John J S, et al. Three-dimensional printing of biological matters. Journal of Science: Advanced Materials and Devices, 2016, 1(1): 1-17.
30.	W?odarczyk-Biegun M K, Del Campo A. 3D bioprinting of structural proteins. Biomaterials, 2017, 134: 180-201.
31.	Zhu Wei, Ma Xuanyi, Gou Maling, et al. 3D printing of functional biomaterials for tissue engineering. Curr Opin Biotechnol, 2016, 40: 103-112.
32.	El-Serafi A T, El-Serafi I T, Elmasry M, et al. Skin regeneration in three dimensions, current status, challenges and opportunities. Differentiation, 2017, 96: 26-29.
33.	劉南波. 3D打印結構性微環境調控表皮細胞分化為汗腺的效應研究. 廣州: 南方醫科大學, 2016.
34.	孫凱, 李瑞欣, 范猛, 等. 3D打印絲素蛋白/膠原蛋白支架的制備及性能. 中國組織工程研究, 2017, 21(2): 280-285.
35.	Rodriguez M J, Brown J, Giordano J, et al. Silk based bioinks for soft tissue reconstruction using 3-dimensional (3D) printing with in vitro and in vivo assessments. Biomaterials, 2017, 117: 105-115.
36.	Pati F, Ha D H, Jang J, et al. Biomimetic 3D tissue printing for soft tissue regeneration. Biomaterials, 2015, 62: 164-175.
37.	Bootsma K, Fitzgerald M M, Free B, et al. 3D printing of an interpenetrating network hydrogel material with tunable viscoelastic properties. J Mech Behav Biomed Mater, 2017, 70: 84-94.
38.	谷龍. 面向皮膚組織工程的水凝膠與細胞打印研究. 杭州: 浙江大學, 2017.
39.	Malyala S K, Kumar Y R, Rao C S P. Organ printing with life cells: a review. Materials Today: Proceedings, 2017, 4(2): 1074-1083.
40.	Rezende R A, Kasyanov V, Mironov V, et al. Organ printing as an information technology. Procedia Engineering, 2015, 110: 151-158.
41.	Jessop Z M, Al-Sabah A, Gardiner M D, et al. 3D bioprinting for reconstructive surgery: Principles, applications and challenges. J Plast Reconstr Aesthet Surg, 2017, 70(9): 1155-1170.
42.	Shafiee A, Atala A. Printing technologies for medical applications. Trends Mol Med, 2016, 22(3): 254-265.
43.	Radenkovic D, Solouk A, Seifalian A. Personalized development of human organs using 3D printing technology. Med Hypotheses, 2016, 87: 30-33.
44.	M?kitie A A, Salmi M, Lindford A, et al. Three-dimensional printing for restoration of the donor face: A new digital technique tested and used in the first facial allotransplantation patient in Finland. J Plast Reconstr Aesthet Surg, 2016, 69(12): 1648-1652.
45.	Martini R, Balit Y, Barthelat F. A comparative study of bio-inspired protective scales using 3D printing and mechanical testing. Acta Biomater, 2017, 55: 360-372.

1. 于家傲. 皮膚修復材料的發展歷程-理念與技術的融合. 中華損傷與修復雜志, 2011, 6(1): 12-15.
2. 王彤華, 周雄麗, 謝利勤, 等. 濕性敷料在傷口護理中的應用進展. 齊齊哈爾醫學院學報, 2016, 37(24): 3078-3079.
3. 劉公洪, 廖毅. 濕性敷料治療在燒傷創面的應用進展. 西南軍醫, 2012, 14(1): 113-114.
4. Kamoun E A, Kenawy E S, Chen Xin. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res, 2017, 8(3): 217-233.
5. Eberlein T, Gerke P, Lorenzc H, et al. Advantages in wound healing by a topical easy to use wound healing lipo-gel for abrasive wounds—Evidence from a randomized, controlled experimental clinical study. Wound Medicine, 2016, 15: 11-19.
6. 馮占錄, 張興宏, 趙燕玲. 濕性治療技術救治26例燒傷病人的體會//第七屆全國燒傷創瘍學術會議論文匯編. 北京: 中國中西醫結合學會燒傷專業委員會, 2002: 107.
7. 陳曉潔, 呂愛鳳, 高晶, 等. 功能敷料的" 傷口濕潤環境愈合”理論與實踐. 生物醫學工程學進展, 2013, 34(1): 31-34.
8. 江敏君, 邱玉友, 廖新芳. 燒傷創面應用濕性愈合療法的效果觀察與成本效益分析. 實用醫學雜志, 2014, 30(15): 2523-2524.
9. 錢程. 殼聚糖纖維醫用敷料的生產及應用. 紡織學報, 2006, 27(11): 100-105.
10. 馬艷紅. 耗材產業:" 增速換擋期”注重動力轉換. 中國醫藥報, 2016-08-04(3).
11. 馬東東, 周玉杰, 路婷婷, 等. 組織工程皮膚研究現狀. 現代生物醫學進展, 2014, 14(6): 1183-1187.
12. 郝文麗, 張平, 吳訓偉. 組織工程皮膚的現狀和展望. 北京生物醫學工程, 2016, 35(1): 94-99.
13. 楊維, 崔占峰. 組織工程皮膚發展現狀. 中國科學: 生命科學, 2015, 45(5): 460-470.
14. 林越威, 曾輝宇, 劉嘯宇, 等. 三維打印技術在人工器官生產上的應用. 生物醫學工程學雜志, 2015, 32(5): 1160-1164.
15. 羅文峰, 楊雪香, 敖寧建. 生物醫用材料的3D打印技術與發展. 材料導報, 2016, 30(7): 81-86.
16. 鄧濱, 歐陽漢斌, 黃文華. 3D打印在醫學領域的應用進展. 中國醫學物理學雜志, 2016, 33(4): 389-392.
17. 魏玉雪, 劉曉秋, 李迪, 等. 3D打印技術在細胞打印方面的應用與發展. 海南醫學, 2017, 28(5): 801-804.
18. 田曉紅, 張彬, 房艷, 等. 大鼠脂肪源性干細胞與三維打印明膠支架的兼容性. 解剖學報, 2017, 48(2): 209-216.
19. 工業和信息化部, 發展改革委, 教育部, 等. 增材制造產業發展行動計劃(2017～2020年). 鑄造設備與工藝, 2018(2): 59-63.
20. 劉鳳珍, 劉明信, 王運華, 等. 3D打印技術在醫學領域中的應用研究進展. 中國材料進展, 2016, 35(5): 381-385.
21. Stansbury J W, Idacavage M J. 3D printing with polymers: Challenges among expanding options and opportunities. Dent Mater, 2016, 32(1): 54-64.
22. Kim K, Park J, Suh J H, et al. 3D printing of multiaxial force sensors using carbon nanotube (CNT)/thermoplastic polyurethane (TPU) filaments. Sens Actuators A Phys, 2017, 263: 493-500.
23. Liu Wei, Wang Daming, Huang Jianghong, et al. Low-temperature deposition manufacturing: A novel and promising rapid prototyping technology for the fabrication of tissue-engineered scaffold. Mater Sci Eng C Mater Biol Appl, 2017, 70(Pt 2): 976-982.
24. Hung K C, Tseng C S, Dai L G, et al. Water-based polyurethane 3D printed scaffolds with controlled release function for customized cartilage tissue engineering. Biomaterials, 2016, 83: 156-168.
25. Mohanty S, Sanger K, Heiskanen A, et al. Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching. Mater Sci Eng C Mater Biol Appl, 2016, 61: 180-189.
26. Muwaffak Z, Goyanes A, Clark V, et al. Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings. Int J Pharm, 2017, 527(1/2): 161-170.
27. Cheng Y L, Chen F. Preparation and characterization of photocured poly (ε-caprolactone) diacrylate/poly (ethylene glycol) diacrylate/chitosan for photopolymerization-type 3D printing tissue engineering scaffold application. Materials Science and Engineering: C, 2017, 81: 66-73.
28. Bégin-Drolet A, Dussault M A, Fernandez S A, et al. Design of a 3D printer head for additive manufacturing of sugar glass for tissue engineering applications. Additive Manufacturing, 2017, 15: 29-39.
29. Munaz A, Vadivelu R K, John J S, et al. Three-dimensional printing of biological matters. Journal of Science: Advanced Materials and Devices, 2016, 1(1): 1-17.
30. W?odarczyk-Biegun M K, Del Campo A. 3D bioprinting of structural proteins. Biomaterials, 2017, 134: 180-201.
31. Zhu Wei, Ma Xuanyi, Gou Maling, et al. 3D printing of functional biomaterials for tissue engineering. Curr Opin Biotechnol, 2016, 40: 103-112.
32. El-Serafi A T, El-Serafi I T, Elmasry M, et al. Skin regeneration in three dimensions, current status, challenges and opportunities. Differentiation, 2017, 96: 26-29.
33. 劉南波. 3D打印結構性微環境調控表皮細胞分化為汗腺的效應研究. 廣州: 南方醫科大學, 2016.
34. 孫凱, 李瑞欣, 范猛, 等. 3D打印絲素蛋白/膠原蛋白支架的制備及性能. 中國組織工程研究, 2017, 21(2): 280-285.
35. Rodriguez M J, Brown J, Giordano J, et al. Silk based bioinks for soft tissue reconstruction using 3-dimensional (3D) printing with in vitro and in vivo assessments. Biomaterials, 2017, 117: 105-115.
36. Pati F, Ha D H, Jang J, et al. Biomimetic 3D tissue printing for soft tissue regeneration. Biomaterials, 2015, 62: 164-175.
37. Bootsma K, Fitzgerald M M, Free B, et al. 3D printing of an interpenetrating network hydrogel material with tunable viscoelastic properties. J Mech Behav Biomed Mater, 2017, 70: 84-94.
38. 谷龍. 面向皮膚組織工程的水凝膠與細胞打印研究. 杭州: 浙江大學, 2017.
39. Malyala S K, Kumar Y R, Rao C S P. Organ printing with life cells: a review. Materials Today: Proceedings, 2017, 4(2): 1074-1083.
40. Rezende R A, Kasyanov V, Mironov V, et al. Organ printing as an information technology. Procedia Engineering, 2015, 110: 151-158.
41. Jessop Z M, Al-Sabah A, Gardiner M D, et al. 3D bioprinting for reconstructive surgery: Principles, applications and challenges. J Plast Reconstr Aesthet Surg, 2017, 70(9): 1155-1170.
42. Shafiee A, Atala A. Printing technologies for medical applications. Trends Mol Med, 2016, 22(3): 254-265.
43. Radenkovic D, Solouk A, Seifalian A. Personalized development of human organs using 3D printing technology. Med Hypotheses, 2016, 87: 30-33.
44. M?kitie A A, Salmi M, Lindford A, et al. Three-dimensional printing for restoration of the donor face: A new digital technique tested and used in the first facial allotransplantation patient in Finland. J Plast Reconstr Aesthet Surg, 2016, 69(12): 1648-1652.
45. Martini R, Balit Y, Barthelat F. A comparative study of bio-inspired protective scales using 3D printing and mechanical testing. Acta Biomater, 2017, 55: 360-372.

Journal of Biomedical Engineering

Utilization of three-dimensional printing technology for repairing skin tissue

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