Application of Silk Fibroin in Biomedical Areas_Journal of Biomedical Engineering

Authors：

JINHuanyu ^1,2 , LIUXing ¹ , YINHua ^2,3 ,  ANYan ^1,2

1. School of Public Health, Medical College of Soochow University, Suzhou 215123, China;
2. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China;
3. College of Textile and Clothing Engineering, Soochow University, Suzhou 215006, China;

Corresponding?author：

ANYan, Email: dranyan@126.com

Keywords：

silk fibroin; drug carrier; tissue engineering; diabetes care; tumor care

DOI：

10.7507/1001-5515.20140043

Video：

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For a long period of time, silk fibroin has been applied in biomedical areas. Along with the development of biotechnology, new functions of silk fibroin are being found and developed. From the suture of surgery to the therapeutic drug and the ordinary tissue engineering frame to high grade frame with drug buffer system, exploitation of silk fibroin is constantly introduced with something new from the old ones. In our review, we summarize the applications of silk fibroin in tissue engineering, drug buffer system and medical care.

Citation： JINHuanyu, LIUXing, YINHua, ANYan. Application of Silk Fibroin in Biomedical Areas. Journal of Biomedical Engineering, 2014, 31(1): 228-232. doi: 10.7507/1001-5515.20140043 Copy

1.	王琳婷, 朱良均, 閔思佳. 絲素蛋白在生物醫學領域的應用研究[J]. 北方蠶業, 2009, 30(3):1-7.
2.	RAMA P, MATUSKA S, PAGANONI G, et al. Limbal stem-cell therapy and long-term corneal regeneration[J]. N Eng J Med, 2010, 363(2):147-155.
3.	BRAY L J, GEORGE K A, AINSCOUGH S L, et al. Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes[J]. Biomaterial, 2011, 32(22):5086-5091.
4.	薛豪杰, 劉琳, 胡丹丹. 低溶脹殼聚糖/絲素蛋白復合膜的制備及性能測試[J]. 蠶業科學, 2011, 37(6):1073-1078.
5.	SERBAN M A, PANILAITIS B, KAPLAN D L. Silk fibroin and polyethylene glycol-based biocompatible tissue adhesives[J]. J Biomed Mater ResA, 2011, 98(4):567-575.
6.	曹陽, 王伯初, 遲少萍. 基于絲素蛋白的藥物緩釋材料[J]. 中國組織工程研究與臨床康復, 2009, 13(8):1533-1536.
7.	WENK E,MERKLE H P,MEINEL L. Silk fibroin as a vehicle for drug delivery applications[J]. J Control Release, 2010, 150(2):128-141.
8.	WENK E,WANDREY A J,MERKLE H P, et al. Silk fibroin spheres as a platform for controlled drug delivery[J]. J Control Release, 2008, 132(1):26-34.
9.	KUNDU J, CHUNG Y I, KIM Y H, et al. Silk fibroin nanoparticles for cellular uptake and control release[J]. Int J Pharm, 2010,388(1-2):242-250.
10.	WANG X, WENK E, MATSUMOTO A, et al. Silk microspheres for encapsulation and controlled release[J]. J Control Release, 2007, 117(3):360-370.
11.	SHI P, GOH J C. Release and cellular acceptance of multiple drugs loaded silk fibroin particles[J]. Int J Pharm, 2011, 420(2):282-289.
12.	孫春光,謝世筠,張芃. 納米絲素顆粒藥物緩釋劑的研制及在治療小鼠潰瘍性結腸炎中的藥物控制釋放作用[J]. 蠶業科學, 2011, 37(4):706-712.
13.	UEBERSAX L,MATTOTTI M, PAPALO?ZOS M, et al. Silk fibroin matrices for the controlled release of nerve growth factor (NGF)[J]. Biomaterials, 2007, 28(30):4449-4460.
14.	WENK E, MURPHY A R, KAPLAN D L, et al. The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration[J]. Biomaterial, 2010, 31(6):1403-1413.
15.	WANG X, WENK E, ZHANG X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering[J]. J Control Release, 2009, 134(2):81-90.
16.	ZHAO J, ZHANG Z, WANG S, et al. Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines[J]. Bone, 2009, 45(3):517-527.
17.	JIANG X, ZHAO J, WANG S, et al. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs[J]. Biomaterial, 2009, 30(27):4522-4532.
18.	黃國平, 陳克平. 家蠶絲素水解物治療糖尿病的研究進展[J].安徽農業科學, 2010,38(25):13577-13579, 13581.
19.	HYUN C K, KIM I Y, FROST S C. Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes[J]. J Nutr,2004, 124(12):3257-3263.
20.	LEE H S, LEE H J, SUH H J. Silk protein hydrolysate increases glucose uptake through up-regulation of GLUT 4 and reduces the expression of leptin in 3T3-L1 fibroblast[J]. Nutr Res, 2011, 31(12):937-943.
21.	PARK K J, SHIN E J, KIM S H, et al. Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells[J]. Pharmacol Res, 2005, 52(4):346-356.
22.	PARK J H, NAM Y, PARK S Y, et al. Silk fibroin has a protective effect against high glucose induced apoptosis in HIT-T15 cells[J]. J Biochem Mol Toxicol, 2011, 25(4):238-243.
23.	BYUN E B, SUNG N Y, KWON S K, et al. In vitro and in vivo studies on the cytotoxicity of irradiated silk fibroin against mouse melanoma tumor cell[J]. Radiation Physics and Chemistry, 2009, 78(7-8):492-431.
24.	BYUN E B, SUNG N Y, KIM J H, et al. Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects[J]. Chem Biol Interact, 2010, 186(1):90-95.
25.	GOBIN A S, RHEA R, NEWMAN R A, et al. Silk-fibroin-coated liposomes for long-term and targeted drug delivery[J]. Int J Nanomedicine, 2006, 1(1):81-87.
26.	CHEEMA S K, GOBIN A S, RHEA R, et al. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells[J]. Int J Pharm, 2007, 341(1-2):221-229.
27.	HOWARD M A, POLO K, PUSIC A L, et al. Breast cancer local recurrence after mastectomy and TRAM flap reconstruction:incidence and treatment options[J]. Plast Reconstr Surg, 2006, 117(5):1381-1386.
28.	GUPTA V, MUN G H, CHOI B, et al. Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold[J]. Ann Biomed Eng, 2011, 39(9):2374-2387.

1. 王琳婷, 朱良均, 閔思佳. 絲素蛋白在生物醫學領域的應用研究[J]. 北方蠶業, 2009, 30(3):1-7.
2. RAMA P, MATUSKA S, PAGANONI G, et al. Limbal stem-cell therapy and long-term corneal regeneration[J]. N Eng J Med, 2010, 363(2):147-155.
3. BRAY L J, GEORGE K A, AINSCOUGH S L, et al. Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes[J]. Biomaterial, 2011, 32(22):5086-5091.
4. 薛豪杰, 劉琳, 胡丹丹. 低溶脹殼聚糖/絲素蛋白復合膜的制備及性能測試[J]. 蠶業科學, 2011, 37(6):1073-1078.
5. SERBAN M A, PANILAITIS B, KAPLAN D L. Silk fibroin and polyethylene glycol-based biocompatible tissue adhesives[J]. J Biomed Mater ResA, 2011, 98(4):567-575.
6. 曹陽, 王伯初, 遲少萍. 基于絲素蛋白的藥物緩釋材料[J]. 中國組織工程研究與臨床康復, 2009, 13(8):1533-1536.
7. WENK E,MERKLE H P,MEINEL L. Silk fibroin as a vehicle for drug delivery applications[J]. J Control Release, 2010, 150(2):128-141.
8. WENK E,WANDREY A J,MERKLE H P, et al. Silk fibroin spheres as a platform for controlled drug delivery[J]. J Control Release, 2008, 132(1):26-34.
9. KUNDU J, CHUNG Y I, KIM Y H, et al. Silk fibroin nanoparticles for cellular uptake and control release[J]. Int J Pharm, 2010,388(1-2):242-250.
10. WANG X, WENK E, MATSUMOTO A, et al. Silk microspheres for encapsulation and controlled release[J]. J Control Release, 2007, 117(3):360-370.
11. SHI P, GOH J C. Release and cellular acceptance of multiple drugs loaded silk fibroin particles[J]. Int J Pharm, 2011, 420(2):282-289.
12. 孫春光,謝世筠,張芃. 納米絲素顆粒藥物緩釋劑的研制及在治療小鼠潰瘍性結腸炎中的藥物控制釋放作用[J]. 蠶業科學, 2011, 37(4):706-712.
13. UEBERSAX L,MATTOTTI M, PAPALO?ZOS M, et al. Silk fibroin matrices for the controlled release of nerve growth factor (NGF)[J]. Biomaterials, 2007, 28(30):4449-4460.
14. WENK E, MURPHY A R, KAPLAN D L, et al. The use of sulfonated silk fibroin derivatives to control binding, delivery and potency of FGF-2 in tissue regeneration[J]. Biomaterial, 2010, 31(6):1403-1413.
15. WANG X, WENK E, ZHANG X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering[J]. J Control Release, 2009, 134(2):81-90.
16. ZHAO J, ZHANG Z, WANG S, et al. Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines[J]. Bone, 2009, 45(3):517-527.
17. JIANG X, ZHAO J, WANG S, et al. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs[J]. Biomaterial, 2009, 30(27):4522-4532.
18. 黃國平, 陳克平. 家蠶絲素水解物治療糖尿病的研究進展[J].安徽農業科學, 2010,38(25):13577-13579, 13581.
19. HYUN C K, KIM I Y, FROST S C. Soluble fibroin enhances insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes[J]. J Nutr,2004, 124(12):3257-3263.
20. LEE H S, LEE H J, SUH H J. Silk protein hydrolysate increases glucose uptake through up-regulation of GLUT 4 and reduces the expression of leptin in 3T3-L1 fibroblast[J]. Nutr Res, 2011, 31(12):937-943.
21. PARK K J, SHIN E J, KIM S H, et al. Insulin sensitization of MAP kinase signaling by fibroin in insulin-resistant Hirc-B cells[J]. Pharmacol Res, 2005, 52(4):346-356.
22. PARK J H, NAM Y, PARK S Y, et al. Silk fibroin has a protective effect against high glucose induced apoptosis in HIT-T15 cells[J]. J Biochem Mol Toxicol, 2011, 25(4):238-243.
23. BYUN E B, SUNG N Y, KWON S K, et al. In vitro and in vivo studies on the cytotoxicity of irradiated silk fibroin against mouse melanoma tumor cell[J]. Radiation Physics and Chemistry, 2009, 78(7-8):492-431.
24. BYUN E B, SUNG N Y, KIM J H, et al. Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects[J]. Chem Biol Interact, 2010, 186(1):90-95.
25. GOBIN A S, RHEA R, NEWMAN R A, et al. Silk-fibroin-coated liposomes for long-term and targeted drug delivery[J]. Int J Nanomedicine, 2006, 1(1):81-87.
26. CHEEMA S K, GOBIN A S, RHEA R, et al. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells[J]. Int J Pharm, 2007, 341(1-2):221-229.
27. HOWARD M A, POLO K, PUSIC A L, et al. Breast cancer local recurrence after mastectomy and TRAM flap reconstruction:incidence and treatment options[J]. Plast Reconstr Surg, 2006, 117(5):1381-1386.
28. GUPTA V, MUN G H, CHOI B, et al. Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold[J]. Ann Biomed Eng, 2011, 39(9):2374-2387.

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Application of Silk Fibroin in Biomedical Areas

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