Advances in the Application of Smart Phones in Modern Medicine_Journal of Biomedical Engineering

Authors：

WANGLin ^1,2 , HUJie ^1,2 , LIFei ^2,3 , WEIHuilin ⁴ , LIYing ⁵ , LUTianjian ² , WANGShuqi ⁶ ,  XUFeng ^1,2

1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China;
2. Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an 710049, China;
3. Department of Applied Chemistry, School of Science, Xi'an Jiaotong University, Xi'an 710049, China;
4. Lauren Biotechnology Ltd., Nanjing 210019, China;
5. School of Electronic Engineering, Xidian University, Xi'an 710126, China;
6. Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, U. S. A;

Corresponding?author：

XUFeng, Email: fengxu@mail.xjtu.edu.cn

Keywords：

Smart phone; Modern medicine; Applications; Advances; Point-of-care testing (POCT)

DOI：

10.7507/1001-5515.20140042

Video：

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Since smart phones have been developed, significant advances in the function of mobile phone due to the development of software, hardware and accessories have been reached. Till now, smart phones have been engaged in daily life with an increasing impact. As a new medical model, mobile phone medicine is emerging and has found widespread applications in medicine, especially in diagnosing, monitoring and screening various diseases. In addition, mobile phone medical application shows great potential trend to improve healthcare in resource-limited regions due to its advantageous features of portability and information communication capability. Nowadays, the scientific and technological issues related to mobile phone medicine have attracted worldwide attention. In this review, we summarize state-of-the-art advances of mobile phone medicine with focus on its diagnostics applications in order to expand the fields of their applications and promote healthcare informatization.

Citation： WANGLin, HUJie, LIFei, WEIHuilin, LIYing, LUTianjian, WANGShuqi, XUFeng. Advances in the Application of Smart Phones in Modern Medicine. Journal of Biomedical Engineering, 2014, 31(1): 222-227. doi: 10.7507/1001-5515.20140042 Copy

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2.	張曉丁,劉靜.基于手機的遠程可視化醫學技術研究[J].中國醫療器械信息,2010,16(10):28-33,79.
3.	WANG H, LIU J. Mobile phone based health care technology[J]. Recent Pat Biomed Eng, 2009, 2(1):15-21.
4.	XIE Q M, LIU J. Mobile phone based biomedical imaging technology:a newly emerging area[J]. Recent Pat Biomed Eng, 2010, 3(1):41-53.
5.	黃碩,劉靜.手機與計算機之間的圖像無線交互傳輸技術及其醫學應用[J].中國醫療器械雜志,2010,34(3):167-171.
6.	LIU L, LIU J. Biomedical sensor technologies on the platform of mobile phones[J]. Front Mech Eng, 2011, 6(2):160-175.
7.	GRANOT Y, IVORRA A, RUBINSKY B. A new concept for medical imaging centered on cellular phone technology[J]. PLoS One, 2008, 3(4):e2075.
8.	ZUROVAC D, AO T A, SNOW R W. Mobile phone text messaging:tool for malaria control in Africa[J]. PLoS Med, 2012, 9(2):e1001176.
9.	王昊,劉靜.睡眠障礙的手機監測方法研究[J].北京生物醫學工程,2010,29(3):270-277.
10.	COXWORTH B. Face-scanning cameras could pick out drunks[EB/OL]. (2012-09-04)[2012-10-04]. http://www.gizmag.com/drunk-face-scanning-cameras/23993/.
11.	唐艷,湯井田.應用移動通訊技術設計心電監護系統[J].生物醫學工程學雜志,2006,23(5):1130-1133.
12.	WONG P. EPI Life:World's first EKG mobile phone[EB/OL]. (2010-06-16)[2012-10-04]. http://news.cnet.com/8301-17938_105-20007953-1.html?part=rssamp;amp;subj=newsamp;amp;tag=2547-1_3-0-20.
13.	ROBERTSON A. New imaging system could let cellphones see through walls[EB/OL]. (2012-04-18)[2012-10-04]. http://www.theverge.com/2012/4/18/2957280/imaging-chip-research-ut-dallas-cell-phone-x-ray-vision.
14.	ISO T, KAWASAKI N, KURAKAKE S. Personal context extractor with multiple sensors on a cell phone[C/OL]. The Seventh IFIP International Conference on Mobile and Wireless Communications Networks (MWCN 2005), Marrakech, Morocco, September 19-21, 2005. (2005-09-21)[2012-10-04]. http://www.ctr.kcl.ac.uk/MWCN2005/Paper/C200525.pdf.
15.	SCULLY C G, LEE J, MEYER J, et al. Physiological parameter monitoring from optical recordings with a mobile phone[J]. IEEE Trans Biomed Eng, 2012, 59(2):303-306.
16.	劉琳,劉靜.手機助老助殘技術的研究與進展[J].中國醫療器械信息,2011,17(1):6-15.
17.	SMITH Z J, CHU K, ESPENSON A R, et al. Cell-phone-based platform for biomedical device development and education applications[J]. PLoS One, 2011, 6(3):e17150.
18.	FITZPATRICK T. Ultrasound imaging now possible with a smartphone[EB/OL]. (20090-4-20)[2012-10-04]. http://news.wustl.edu/news/pages/13928.aspx.
19.	BALAN E. HealthPia GlucoPhone, with Blood Glucose Meter[EB/OL]. (20070-8-14)[2012-10-04]. http://news.softpedia.com/news/HealthPia-GlucoPhone-with-Blood-Glucose-Meter-62664.shtml.
20.	CARROLL A E, MARRERO D G, DOWNS S M. The healthpia glucopack diabetes phone:a usability study[J]. Diabetes Technol Ther, 2007, 9(2):158-164.
21.	CARROLL A E, DIMEGLIO L A, STEIN S, et al. Using a cell phone-based glucose monitoring system for adolescent diabetes management[J]. Diabetes Educ, 2011, 37(1):59-66.
22.	MACMANUS C, KATZ L. Android phones get heart-healthy[EB/OL]. (2010-10-14)[2012-10-04]. http://news.cnet.com/8301-17938_105-20019684-1.html.
23.	IWAMOTO J, OGAWA H, MAKI H, et al. A mobile phone-based ecg and heart sound monitoring system-biomed 2011[J]. Biomed Sci Instrum, 2011, 47:160-164.
24.	EHMEN H, HAESNER M, STEINKE I, et al. Comparison of four different mobile devices for measuring heart rate and ECG with respect to aspects of usability and acceptance by older people[J]. Appl Ergon, 2012, 43(3):582-587.
25.	王海濱,江鐘偉,董秀成,等.基于聽診器的心音采集解析系統[J].生物醫學工程學雜志,2009,26(2):282-287.
26.	李建銀.基于智能手機平臺的心音采集和無線傳輸技術的研究[D].南京:南京郵電大學,2011.
27.	SUTHERLAND K. StethoCloud promises a low-cost solution to pneumonia diagnoses[EB/OL].(2012-09-04)[2012-10-04]. http://www.gizmag.com/stethoscope-stethocloud-app/23999/.
28.	BRESLAUER D N, MAAMARI R N, SWITZ N A, et al. Mobile phone based clinical microscopy for global health applications[J]. PLoS One, 2009, 4(7):e6320.
29.	ZHU H, MAVANDADI S, COSKUN A F, et al. Optofluidic fluorescent imaging cytometry on a cell phone[J]. Anal Chem, 2011, 83(17):6641-6647.
30.	UCLA Office of Intellectual Property & Industry Sponsored Research. A Cell Phone-Based Electrical Biosensor[EB/OL]. (2011)[2012-10-04]. http://techtransfer.universityofcalifornia.edu/NCD/22116.html?utm_source=iBridgeamp;utm_medium=webpageamp;utm_term=ncdid_22116amp;utm_campaign=TechWebsites.
31.	WANG S, ZHAO X, KHIMJI I, et al. Integration of cell phone imaging with microchip elisa to detect ovarian cancer he4 biomarker in urine at the point-of-care[J]. Lab Chip, 2011, 11(20):3411-3418.
32.	MERTZ L. Ultrasound fetal monitoring spectrometer there's an app for that!:biomedical smart phone apps are taking healthcare by storm[J]. IEEE Pulse, 2012, 3(2):16-21.

1. International Telecommunication Union. Key statistical highlights:ITU data release June 2012[EB/OL]. (2012-06)[2012-10-04].http://www.itu.int/ITUD/ict/statistics/material/pdf/2011%20Statistical%20highlights_June_2012.pdf.
2. 張曉丁,劉靜.基于手機的遠程可視化醫學技術研究[J].中國醫療器械信息,2010,16(10):28-33,79.
3. WANG H, LIU J. Mobile phone based health care technology[J]. Recent Pat Biomed Eng, 2009, 2(1):15-21.
4. XIE Q M, LIU J. Mobile phone based biomedical imaging technology:a newly emerging area[J]. Recent Pat Biomed Eng, 2010, 3(1):41-53.
5. 黃碩,劉靜.手機與計算機之間的圖像無線交互傳輸技術及其醫學應用[J].中國醫療器械雜志,2010,34(3):167-171.
6. LIU L, LIU J. Biomedical sensor technologies on the platform of mobile phones[J]. Front Mech Eng, 2011, 6(2):160-175.
7. GRANOT Y, IVORRA A, RUBINSKY B. A new concept for medical imaging centered on cellular phone technology[J]. PLoS One, 2008, 3(4):e2075.
8. ZUROVAC D, AO T A, SNOW R W. Mobile phone text messaging:tool for malaria control in Africa[J]. PLoS Med, 2012, 9(2):e1001176.
9. 王昊,劉靜.睡眠障礙的手機監測方法研究[J].北京生物醫學工程,2010,29(3):270-277.
10. COXWORTH B. Face-scanning cameras could pick out drunks[EB/OL]. (2012-09-04)[2012-10-04]. http://www.gizmag.com/drunk-face-scanning-cameras/23993/.
11. 唐艷,湯井田.應用移動通訊技術設計心電監護系統[J].生物醫學工程學雜志,2006,23(5):1130-1133.
12. WONG P. EPI Life:World's first EKG mobile phone[EB/OL]. (2010-06-16)[2012-10-04]. http://news.cnet.com/8301-17938_105-20007953-1.html?part=rssamp;amp;subj=newsamp;amp;tag=2547-1_3-0-20.
13. ROBERTSON A. New imaging system could let cellphones see through walls[EB/OL]. (2012-04-18)[2012-10-04]. http://www.theverge.com/2012/4/18/2957280/imaging-chip-research-ut-dallas-cell-phone-x-ray-vision.
14. ISO T, KAWASAKI N, KURAKAKE S. Personal context extractor with multiple sensors on a cell phone[C/OL]. The Seventh IFIP International Conference on Mobile and Wireless Communications Networks (MWCN 2005), Marrakech, Morocco, September 19-21, 2005. (2005-09-21)[2012-10-04]. http://www.ctr.kcl.ac.uk/MWCN2005/Paper/C200525.pdf.
15. SCULLY C G, LEE J, MEYER J, et al. Physiological parameter monitoring from optical recordings with a mobile phone[J]. IEEE Trans Biomed Eng, 2012, 59(2):303-306.
16. 劉琳,劉靜.手機助老助殘技術的研究與進展[J].中國醫療器械信息,2011,17(1):6-15.
17. SMITH Z J, CHU K, ESPENSON A R, et al. Cell-phone-based platform for biomedical device development and education applications[J]. PLoS One, 2011, 6(3):e17150.
18. FITZPATRICK T. Ultrasound imaging now possible with a smartphone[EB/OL]. (20090-4-20)[2012-10-04]. http://news.wustl.edu/news/pages/13928.aspx.
19. BALAN E. HealthPia GlucoPhone, with Blood Glucose Meter[EB/OL]. (20070-8-14)[2012-10-04]. http://news.softpedia.com/news/HealthPia-GlucoPhone-with-Blood-Glucose-Meter-62664.shtml.
20. CARROLL A E, MARRERO D G, DOWNS S M. The healthpia glucopack diabetes phone:a usability study[J]. Diabetes Technol Ther, 2007, 9(2):158-164.
21. CARROLL A E, DIMEGLIO L A, STEIN S, et al. Using a cell phone-based glucose monitoring system for adolescent diabetes management[J]. Diabetes Educ, 2011, 37(1):59-66.
22. MACMANUS C, KATZ L. Android phones get heart-healthy[EB/OL]. (2010-10-14)[2012-10-04]. http://news.cnet.com/8301-17938_105-20019684-1.html.
23. IWAMOTO J, OGAWA H, MAKI H, et al. A mobile phone-based ecg and heart sound monitoring system-biomed 2011[J]. Biomed Sci Instrum, 2011, 47:160-164.
24. EHMEN H, HAESNER M, STEINKE I, et al. Comparison of four different mobile devices for measuring heart rate and ECG with respect to aspects of usability and acceptance by older people[J]. Appl Ergon, 2012, 43(3):582-587.
25. 王海濱,江鐘偉,董秀成,等.基于聽診器的心音采集解析系統[J].生物醫學工程學雜志,2009,26(2):282-287.
26. 李建銀.基于智能手機平臺的心音采集和無線傳輸技術的研究[D].南京:南京郵電大學,2011.
27. SUTHERLAND K. StethoCloud promises a low-cost solution to pneumonia diagnoses[EB/OL].(2012-09-04)[2012-10-04]. http://www.gizmag.com/stethoscope-stethocloud-app/23999/.
28. BRESLAUER D N, MAAMARI R N, SWITZ N A, et al. Mobile phone based clinical microscopy for global health applications[J]. PLoS One, 2009, 4(7):e6320.
29. ZHU H, MAVANDADI S, COSKUN A F, et al. Optofluidic fluorescent imaging cytometry on a cell phone[J]. Anal Chem, 2011, 83(17):6641-6647.
30. UCLA Office of Intellectual Property & Industry Sponsored Research. A Cell Phone-Based Electrical Biosensor[EB/OL]. (2011)[2012-10-04]. http://techtransfer.universityofcalifornia.edu/NCD/22116.html?utm_source=iBridgeamp;utm_medium=webpageamp;utm_term=ncdid_22116amp;utm_campaign=TechWebsites.
31. WANG S, ZHAO X, KHIMJI I, et al. Integration of cell phone imaging with microchip elisa to detect ovarian cancer he4 biomarker in urine at the point-of-care[J]. Lab Chip, 2011, 11(20):3411-3418.
32. MERTZ L. Ultrasound fetal monitoring spectrometer there's an app for that!:biomedical smart phone apps are taking healthcare by storm[J]. IEEE Pulse, 2012, 3(2):16-21.

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