ObjectiveTo understand the possible influential factors and the effectiveness of interventions for quality of life in breast cancer survivors. MethodThe latest literatures about studies on quality of life in breast cancer survivors were reviewed. ResultsAlthough the cure rate and survival rate of patients with breast cancer had improved, breast cancer as a major stress event, the disease itself and treatment related adverse reactions might cause the fatigue, activity decline, anxiety, depression, and other negative emotions of patients, which seriously affected the quality of life of patients and survival prognosis. The patients’ age, socio-economic background, tumor characteristics, and treatment methods were the factors affecting their quality of life. To a certain extent, meditation, music therapy, and proper physical exercise could improve the quality of life of patients with breast cancer. ConclusionBreast cancer itself and related treatment methods may affect not only the affected organs, but also multiple dimensions of patients’ quality of life, so attention should be paid to improve quality of life in breast cancer survivors, providing with individualized interventions.
Objective To investigate the relevance of prognostic nutritional index (PNI) and albumin to fibrinogen ratio (AFR) to health-related quality of life in patients with venous thromboembolism (VTE) after 1 year discharge. MethodsThe clinical data from the 292 patients with VTE receiving 3 or 6 months of anticoagulation therapy at the West China Hospital of Sichuan University, from January 2020 to October 2024, were retrospective analyzed. Generalized linear model (Gamma distribution with log link) was used to assess the relationship of PNI, AFR, and their interaction termwith the Global Index Score (GIS) at 1 year discharge. ResultsThe correlation analysis showed that AFR (rs=0.325, P<0.001) and PNI (rs=0.322, P<0.001) were positively correlated with GIS after 1 year discharge. In adjusted generalized linear model controlling for age, education, and comorbidities, pulmonary embolism [without pulmonary embolism vs. pulmonary embolism: MR=0.942, 95%CI (0.897, 0.989), P=0.017], VTE recurrence [without VTE recurrence vs. VTE recurrence: MR=1.236, 95%CI (1.168, 1.308), P<0.001], AFR level [MR=1.038, 95%CI (1.018, 1.059), P<0.001] and PNI level [MR=1.014, 95%CI (1.009, 1.018), P<0.001] were associated with GIS after 1 year discharge, PNI and AFR had significant negative effect on GIS [MR=0.999, 95%CI (0.999, 1.000), P<0.001)]. ConclusionsPNI and AFR are associated with health-related quality of life in VTE patients after 1 year discharge. A non-linear interaction between PNI and AFR suggesting that there is a complicated coordinate regulation between them.