Non-anticoagulated continuous renal replacement therapy (CRRT) is usually the main treatment choice for high-risk bleeding patients due to its good safety. The coagulation and shortened lifespan of extracorporeal circulation circuits are the main challenges faced by non-anticoagulated CRRT, and it is particularly important to explore the factors that affect the lifespan of non-anticoagulated CRRT extracorporeal circulation circuits. This article reviews the optimization strategies for extending the lifespan of non-anticoagulated CRRT extracorporeal circulation circuits, including the selection of vascular access and catheter, as well as the setting of CRRT mode, blood flow rate, circuit flush, and replacement fluid dilution methods. The aim is to provide a reference for practitioners in the field of kidney disease and critical care medicine.