ObjectiveTo investigate the effect of positive family behavior support on emotional and behavioral problems in preschool children with epilepsy. Methods A total of 80 preschool epileptic children and their parents who were admitted to the Department of Neurology of our hospital from October 2022 to February 2023 were selected as the research objects, and were divided into experimental group and control group with 40 cases each by random number table method. The control group received neurology routine nursing, and the experimental group received positive family behavior support intervention based on the control group. The scores of family intimacy and adaptability scale, strengths and difficulties questionnaire, medication compliance and quality of life of epilepsy children were compared before and after intervention between the two groups. ResultsAfter intervention, the scores of strength and difficulty questionnaire in experimental group were lower than those in control group (P<0.05), and the scores of family intimacy and adaptability scale, quality of life and medication compliance in experimental group were higher than those in control group (all P<0.05). ConclusionThe application of positive family behavior support program can reduce the occurrence of emotional behavior problems, improve family closeness and adaptability, improve medication compliance, and improve the quality of life of preschool children with epilepsy.
Childhood is the key period of psychological and behavioral development of children. The changes of children's psychological behavior during this period have an impact on the psychological and behavioral patterns of adolescents and even adults. Epilepsy is a chronic and recurrent disease, which affect the development emotional behavior problem of children with epilepsy seriously. This paper reviewed the influencing factors, measuring methods and intervention of emotional behavior problems in children with epilepsy so as to alleviate the negative emotion and behavior problems and provide quality of life in children with epilepsy.
目的 評估替比夫定與阿德福韋酯聯合治療優化阿德福韋酯單藥治療應答不佳的陽性慢性乙型肝炎患者的療效。 方法 選擇2008年6月－2009年8月間共26例阿德福韋酯治療至少12個月且病毒學應答不佳的乙型肝炎病毒e抗原（HBeAg），陽性的慢性乙型肝炎患者，在10 mg阿德福韋酯治療的基礎上，加用600 mg替比夫定。肝功能和乙型肝炎病毒（HBV） DNA每3個月評估1次，乙型肝炎兩對半和腹部B型超聲每半年評估1次。 結果 在第1年的治療期間，所有患者血清HBV DNA水平均呈進行性下降，其中24例（92.3%）血清HBV DNA水平在聯合治療12個月時低于檢測值下限，有25例（96.2%）患者丙氨酸轉氨酶水平復常。治療6個月時，分別有7例（26.9%）和2例（7.7%）患者發生HBeAg消失和血清學轉換；治療12個月時，分別有11例（42.3%）和8例（30.8%）患者發生HBeAg消失和血清學轉換。整個治療期間，26例患者均未出現病毒學突破。 結論 阿德福韋酯單藥治療應答不佳時，加用替比夫定可有效控制病毒，使患者獲得較好的病毒學、生化學和免疫學應答。Objective To evaluate the curative efficacy of telbivudine combined with defovir dipivoxil on positive-HBeAg chronic hepatitis B patients with suboptimal response to adefovir dipivoxil. Methods A total of 26 HBeAg-positive patients with suboptimal response to adefovir dipivoxil (treated with adefovir dipivoxil for more than 12 months) were treated with adefovir dipivoxil 10 mg in addition to telbivudine 600 mg between June 2008 and August 2009. Liver function and serum hepatitis B virus (HBV) DNA tests were assessed at the baseline and 3-month intervals, whereas HBV serological markers and abdominal ultrasonography were carried out every 6 months. Results During the first year of treatment, all patients showed a progressive decline of serum HBV DNA levels; while undetectable serum HBV DNA and normalization of alanine aminotransferase was achieved in 24(92.3%) and 25 (96.2%) patients, respectively, at the end of the first year of treatment. The 6- and 12-month cumulative rates of HBeAg loss were 26.9% (7/26) and 42.3% (11/26), respectively; and corresponding cumulative rates of HBeAg/anti-HBe seroconversion were 7.7% (2/26) and 30.8 (8/26), respectively. During the observation period, no virological breakthrough was detected. Conclusion Telbivudine combined with defovir dipivoxil may be a good choice for patients with suboptimal response to adefovir dipivoxil, which could induce effective viral inhibition and help patients obtain more virological, biochemical and immunological responses.
【摘要】 目的 分析腺苷蛋氨酸治療慢性乙型肝炎高膽紅素血癥的臨床療效。 方法 回顧性分析2010年1-12月28例接受腺苷蛋氨酸（2 000 mg靜脈滴注，1次/d）治療慢性乙型肝炎高膽紅素血癥患者的臨床資料，并對腺苷蛋氨酸治療慢性重癥乙型肝炎高膽紅素血癥后癥狀、體征及實驗室檢測指標的改變情況進行總結，利用多因素logistic回歸分析方法探索與療效相關的預測因素。根據相關癥狀、體征和實驗室結果的不同，將療效分為顯效、有效和無效3類。 結果 28例患者使用腺苷蛋氨酸治療4周后，顯效20例（71.4%），有效4例（14.3%），無效4例（14.3%）。多因素logistic回歸分析提示病程短、并發癥少是影響腺苷蛋氨酸療效的獨立預測因素。 結論 腺苷蛋氨酸是治療慢性乙型肝炎高膽紅素血癥有效，發病時間短及并發癥少的患者退黃效果更好。【Abstract】 Objective To investigate the curative efficacy of ademetionine in the treatment of hyperbilirubinemia for chronic hepatitis B patients. Methods The clinical data of 28 chronic hepatitis B patients with intrahepatic cholestasis receiving intravenous ademetionine treatment (2 000 mg per day) were retrospectively analyzed. Patients’ symptoms, body signs and laboratory examination results were summarized, and predictors for efficacy were investigated using multiple regression analysis. In this study, the curative efficacy was classified into remarkable efficacy, efficacy and inefficacy, according to the clinical data. Results After one-month treatment with ademetionine, the percentage for remarkable efficacy, efficacy and inefficacy was 71.4%, 14.3%, and 14.3% respectively. Multivariate logistic regression analysis showed that short disease duration and fewer complications were independent predictors for remarkable efficacy of ademetionine treatment. Conclusion Ademetionine is an effective agent for the treatment of hyperbilirubinemia in chronic hepatitis B patients, and the result is especially good for patients with short duration and fewer complications.
Objective Based on “timing it right”, the application effect of the continuous nursing program in school-age children with epilepsy. Methods A total of 80 epileptic children and primary caregiver who were admitted to the Department of Neurology of Wuxi a third class A children’s hospital from October 2022 to March 2023 were selected as the research objects, and were divided into experimental group and control group with 40 cases each by convenience sampling. The control group was given routine care, and the intervention group was given a continuous nursing for school-age children with epilepsy based on timing theory. The continuous nursing process was divided into four stages: diagnosis stage, treatment stage,preparation stage, and convalescence stage.According to the needs of the different stages of the disease,In each stage,the intervention was carried out from disease cognition, emotional support, Correct care, psychological adjustment, rehabilitation training. TO Reduce the burden on caregivers and promote the recovery of patients. The results of Knowledge of the disease, burden of Caregiver and quality of life were compared between the two groups before intervention, before discharge and Three months after discharge through Epileptic disease health knowledge questionnaire, Zarit Care-giver Burden Interview, PedsQTM4.0. Results After intervention, The degree of seizures-related knowledge mastered by the main caregivers of children with epilepsy, the quality of life were significantly improved (all P<0.05). Conclusion The implementation of the continuity nursing plan based on the timing theory can improve the knowledge level of the main caregivers of epilepsy children, improve their caring ability, and improve the quality of life of epilepsy children.
ObjectiveTo explore the effect of family-school-hospital application in continuous nursing care for children with epilepsy. Methods120 children with epilepsy admitted to Children's Hospital Affiliated to Jiangnan University from January 2021 to October 2022 were randomly divided into two groups, each with 60 cases. The control group received routine care, while the experimental group received family-school-hospital continuous care. Compare the awareness of epilepsy knowledge, disease control effectiveness, medication compliance, negative emotions, physical and mental status, and quality of life before and after nursing between the families of two groups of children with epilepsy. ResultsAfter 2 months of nursing care, the scores of family members' knowledge of epilepsy in the experimental group were higher than the control group (P<0.05). The effect of disease control in the experimental group was better the control group (P<0.05). The drug compliance of the experimental group was higher than the control group (P<0.05). The quality of life score in the intervention group was higher than the control group (P<0.05). ConclusionThe application of family-school-hospital in the continuous care of children with epilepsy can improve their family members' awareness of epilepsy knowledge, effectively control the disease, improve medication compliance, improve negative emotions and physical and mental conditions, and thus improve the quality of life of children.