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    find Author "ZHANG Ying" 65 results
    • Evidence-based Case Discussion for Post-ERCP Hemobilia

      Objective To analyze and explain how to treat 1 patient with post-ERCP hemobilia based on best clinical evidence. Methods We used EST and EPBD, ENBD, Hemobilia as key words to search MEDLINE (1978 ~ 2004) and CBMdisc(1978 ~ 2004) to find the best clinical evidence and evaluated the quality of evidence. Results According to the evidence, we found that endoscopic papillary balloon dilation (EPBD) or endoscopic nasobiliary drainage ( ENBD ) may be more effective and better tolerated in the treatment ofpost-ERCP hemobilia. Our patient did not receive sufficient medical treatment after hemobilia. He was not given a general assessment before surgery including liver function tests. As a result, the patient died of liver failure and its complications. Conclusions We should treat such patients promptly and efficiendy after hemobilia. We should also evaluate their general condition properly before the operation.

      Release date:2016-09-07 02:25 Export PDF Favorites Scan
    • Transthoracic Balloon Valvuloplasty for Severe and Critical Pulmonary Valve Stenosis in Infants below One Year

      Abstract: Objective To summarize the immediate effects and the near and midterm followup results of transthoracic balloon valvuloplasty for newborns and infants with severe and critical pulmonary valve stenosis to find out an effective plan for onestop balloon valvuloplasty. Methods From March 2006 to March 2010, 32 patients including 23 males and 9 females with severe and critical pulmonary valve stenosis were treated in Fu Wai Hospital. Their age ranged from 5 days to 11 months (4.59±3.21 months). Weight of the patients ranged from 2.3 to 10.5 kg (6.48±2.05 kg). Dilatation was performed under general anesthesia with intubation and the guidance of echocardiography. During the follow-up period, all survivors had serial echocardiographic assessment to measure the transpulmonary pressure gradient (TPG) and the degree of pulmonary regurgitation. Results All operations were successful with no severe postoperative complications. Hemodynamic indexes were stable after operation with TPG lowered from from 82±27 mm Hg preoperatively to 23±12 mm Hg postoperatively (t=15.28, Plt;0.05). Only 4 patients had a TPG of more than 40 mm Hg on echocardiography before leaving the hospital. Tricuspid regurgitation was decreased significantly with 17 cases of nonregurgitation, 13 cases of light regurgitation and 2 cases of moderate regurgitation. Saturation of peripheral oxygen in all the patients increased to higher than 95%. Followup time ranged from 1 month to 4 years (16±11 months). The results of the follow-up were satisfying for all the patients. The average TPG was 17±10 mm Hg with only one above 40 mm Hg. Pulmonary valve regurgitation was found in 24 patients including 23 with light pulmonary regurgitation and 1 with moderate regurgitation. Conclusion Transthoracic balloon valvuloplasty for newborns and infants with severe and critical pulmonary valve stenosis is safe and effective.

      Release date:2016-08-30 06:03 Export PDF Favorites Scan
    • Clincal Aanlysis of 23 Cases with Craniocerebral Injury Combined with Optic Nerve Injury

      目的:探討顱腦損傷合并視神經損傷的發病機制及治療.方法:對23例顱腦損傷合并視神經損傷患者的臨床資料做回顧性分析。結果:經過積極治療部分患者視力有不同程度改善。結論:治療顱腦損傷合并視神經損傷,強調神經外科和眼科協同處理,掌握治療時機。

      Release date:2016-09-08 10:02 Export PDF Favorites Scan
    • Effect of Rehabilitation on Unilateral Spatial Agnosia in Post-Stroke Patients

      Objective To investigate the assessment and treatment methods for unilateral spatial agnosia as well as its influence on the functional recovery of patients after stroke, so as to comprehensively understand unilateral spatial agnosia and formulate an effective treatment plan to improve the effect of rehabilitation for stroke patients. Methods A total of 86 patients with unilateral spatial agnosia were analyzed and a pre-treatment and post-treatment comparison was done. Results Of the 86 patients, 21% suffered from unilateral spatial agnosia. The occurrence of unilateral spatial agnosia was related to the location of the stroke lesion. The treatment group witnessed significant improvement after rehabilitation training of correcting unilateral spatial agnosia (Plt;0.05). Conclusion The correct rehabilitation method is beneficial for an early improvement in a patient’s cognitive ability. This also lays a foundation for the recovery of function in their limbs.

      Release date:2016-09-07 02:12 Export PDF Favorites Scan
    • Efficacy of antibiotics on the outcomes of patients with non-small cell lung cancer treated with immune checkpoint inhibitors: a meta-analysis

      ObjectiveTo systematically review the efficacy of antibiotics on the outcomes of patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors. MethodsPubMed, EMbase, Web of Science, The Cochrane Library, CNKI, WanFang Data, VIP and CBM databases were electronically searched to collect cohort studies on efficacy of antibiotics on the outcomes of patients with NSCLC treated with immune checkpoint inhibitors from inception to August 1st, 2021. Two reviewers independently screened literature, extracted data, and evaluated the risk of bias of the included studies. Meta-analysis was then performed by using RevMan 5.3 software. ResultsA total of 27 cohort studies involving 7 087 patients were included. The results of meta-analysis showed that antibiotic use was associated with poor overall survival (OS) (HR=2.04, 95%CI 1.68 to 2.49, P<0.000 01) and progression free survival (PFS) (HR=1.63, 95%CI 1.35 to 1.99, P<0.000 01). ConclusionCurrent evidence shows that antibiotic use is associated with poor OS and PFS. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.

      Release date:2022-03-29 02:59 Export PDF Favorites Scan
    • Bibliometric analysis on international cooperation of rehabilitation robots in China from 2000 to 2019

      Rapid development is undergoing in the field of rehabilitation robots, and more countries (regions) are participating in international cooperation and becoming academic contributors. Here in this study, the bibliometric method is used to determine the dynamics and developments of international cooperation in China. The publication data are indexed in Web of Science with search term of rehabilitation robot from 2000 to 2019. Compared with other countries (regions), publication with international co-authors and institutes participating in international cooperation are studied by assessment of indicators such as the cooperation degree, cooperation frequency, and the frequency of citations. The results show that in the past two decades, international scientific cooperation has shown a positive tendency in China, and participating in international collaboration could improve China’s impact on the global rehabilitation robot. The United States, England and Japan are the top three countries in number of cooperation with China. Our findings provide valuable information for researchers to better understand China’s international scientific collaboration in rehabilitation robot.

      Release date:2020-10-20 05:56 Export PDF Favorites Scan
    • Relationship between Inducible Nitric Oxide Synthase and Endothelin mRNA Expression and Intestinal Damage and Effect of Salvia in Acute Pancreatitis

      【摘要】目的探討重癥急性胰腺炎(SAP)時胰腺組織的誘導型一氧化氮合成酶(iNOS)、內皮素(ET1) mRNA表達狀態, 以及與血漿中NO、ET1濃度和腸道損傷的關系及丹參治療的影響。方法Wistar大鼠45只隨機分為3組:SAP模型組(A組),SAP丹參治療組(B組),假手術 組(C組),進行不同治療和觀察分析。結果A組血中淀粉酶(AML)、ET1、NO、內毒素(LPS)含量、125 I白蛋白累積指數及腹水量均顯著高于C組(Plt;0.01);與A組比較,B組胰腺ET1和iNOS mRNA表達較弱,血中AML、ET1、NO、LPS及腹水量顯著下降(Plt;0.01),125 I白蛋白累積指數較A組也有下降,但無差異(Pgt;0.05)。結論SAP時存在腸道損傷,胰腺組織ET1、iNOS mRNA的過度表達,使血中ET1、NO濃度升高,造成腸道屏障功能受損,腸通透性增加,引起內毒素血癥。丹參注射液通過減輕SAP時胰腺的病理損害程度,下調胰腺ET1和iNOS mRNA的表達,使血中ET1、NO濃度下降,對SAP及其腸道損傷有一定治療作用。

      Release date:2016-09-08 09:31 Export PDF Favorites Scan
    • Interpretation of the statistical analysis plan (SAP) extended reporting guidelines and their enlightenment for the design of early stage clinical studies of new drugs

      The utilisation of statistical analysis plan (SAP) has the potential to enhance the reliability, transparency, and impartiality of statistical analysis procedures in the context of clinical studies. These plans are primarily designed for late phase clinical studies, namely phase Ⅱ and phase Ⅲ randomised controlled trials. The extended SAP reporting guidelines for early phase clinical studies, i.e., phase Ⅰ clinical studies and phase Ⅱ non-randomised controlled trials, have been expanded from the original reporting guidelines in six key areas: trial purpose, design, Bayesian statistics, data simulation, sample size, and the application of ICH E9 (R1). The expanded reporting guidelines facilitate the standardisation of SAP for early phase clinical trials, enhance the transparency and reproducibility of early phase clinical studies, and thereby improve the quality of early phase clinical studies. This, in turn, plays a pivotal role in later phase clinical studies.

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    • New type of sutured titanium wire combined with titanium nail internal fixation for correction of serious old medial canthus deformity

      ObjectiveTo evaluate the effectiveness of a new type of sutured titanium wire combined with titanium nail internal fixation in correction of serious old medial canthus deformity.MethodsBetween March 2012 and June 2015, 18 patients with unilateral serious old medial canthus deformity were treated. There were 14 males and 4 females. The patient’s age ranged from 23 to 62 years (mean, 42 years). The causes of deformity included accident injury in 10 cases, boxing injury in 4 cases, sharp device scratching in 3 cases, and animal bite in 1 case. All patients had been treated with suture or steel wire fixation in other hospitals to correct the medial canthus deformity and the deformity recurred. The interval between this operation and the first operation was 6 months to 2 years (mean, 16 months). The nasal root or medial canthus skin scar incision was used as the operative approach, and the adhesion of the medial canthus ligament to the adjacent tissues was fully loosened, then the tail end of the new type sutured titanium wire was fixed to the residual end of the medial canthus ligament. After passing through the scar tissue, the needle end of wire was fixed on the titanium nail in the bone wall of anterior lacrimal crest. The position and shape of the medial canthus angle was determined by adjusting the tightness of titanium wire.ResultsAll incisions healed by first intention. All patients were followed up 6-12 months (mean, 10 months). In 16 cases, the medial canthus deformity was obviously corrected, and the appearances of bilateral eyes were basically symmetrical, without exposure of titanium nail and titanium wire. The medial canthus was retreated at 2 mm after 6 months in 2 cases, who were satisfied with their appearance without reoperation.ConclusionApplication of the new type of suture titanium wire combined with titanium nail in the correction of serious old medial canthus deformity can achieve good effectiveness with the low recurrence rate.

      Release date:2018-05-30 04:28 Export PDF Favorites Scan
    • Application of poly(styrene-block-isobutylene-block-styrene) and its crosslinked product in ophthalmic diseases

      Poly(styrene-block-isobutylene-block-styrene) (SIBS) and its crosslinked product crosslinked polyisobutylene (xPIB) are a kind of novel thermoplastic elastomer. They have excellent biocompatibility and stability, which are suitable for long-term implantation in human body. At present, SIBS is widely used in cardiovascular diseases, and also has preliminary application in ophthalmology. This article reviews the application and research progress of SIBS and xPIB in ophthalmic glaucoma minimally drainage tube material, intraocular lens material, new sclera buckle material and orbital defect filler, with a view of providing reference for the clinical application of such biomedical materials in ophthalmology.

      Release date:2023-02-14 05:33 Export PDF Favorites Scan
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