The central aim of this experiment was to compare the articulatory and acoustic characteristics of students with normal hearing (NH) and school aged children with hearing loss (HL), and to explore the articulatory-acoustic relations during the nasal finals. Fourteen HL and 10 control group were enrolled in this study, and the data of 4 HL students were removed because of their high pronunciation error rate. Data were collected using an electromagnetic articulography. The acoustic data and kinematics data of nasal finals were extracted by the phonetics and data processing software, and all data were analyzed by t test and correlation analysis. The paper shows that, the difference was statistically significant (P<0.05 orP<0.01) in different vowels under the first two formant frequencies (F1, F2), the tongue position and the articulatory-acoustic relations between HL and NH group. The HL group’s vertical movement data-F1 relations in /en/ and /eng/ are same as NH group. The conclusion of this study about participants with HL can provide support for speech healing training at increasing pronunciation accuracy in HL participants.
目的 研究低碘飲食對大鼠甲狀腺功能的影響及c-Jun在腎組織中的表達差異，探討c-Jun在低碘大鼠腎臟組織中表達的意義。 方法 給予Wistar大鼠低碘飼料，通過飲用不同碘濃度飲水分組,測定甲狀腺功能。利用免疫組織化學方法分析腎臟組織中c-Jun的激活變化情況。 結果 重度低碘組與輕度低碘組、正常對照組比較三碘甲狀腺原氨酸(TT3)、血清總甲狀腺素(TT4)、游離三碘甲狀腺原氨酸(FT3)、游離甲狀腺素(FT4)均明顯下降(Plt;0.05)。輕度低碘組與正常對照組相比，TT4、FT3明顯下降(Plt;0.05)，TT3、FT4稍有降低(Pgt;0.05)。c-Jun在低碘大鼠腎組織中表達增強，與低碘程度有依賴關系，且在腎小球內的表達明顯強于腎小管。 結論 低碘攝入可引起腎組織中c-Jun的過度表達，進而引起腎臟損傷。