Cancer prevention and control is an important healthcare task towards major diseases of the Chinese people and an important part of the “Healthy China 2030” plan outline. This article summarizes and introduces the current status and practical experience of subnational cancer prevention and treatment status in Yibin City and Ya’an City of Sichuan Province. Lung cancer, digestive system cancers, and cervical and breast cancers compose of the majority of cancers with high incidence. In the aspect of cancer epidemiology, there are certain disparities among cities and between urban and rural areas, among which the mortality risk of cancer in rural areas is higher. In Yibin and Ya’an cities, the specialized agencies and governance system for subnational cancer prevention and control are still in the early stage of development, and the background data such as cancer-specific survival rate, public awareness of core knowledge on cancer prevention and control, quality control of key techniques, and healthcare resources in subnational areas are still unclear. Therefore, all levels of cancer prevention and control need further strengthening the organizational leadership and system construction, and promoting the hierarchic healthcare and balanced development.