Objective To review the expression of mechano-growth factor (MGF) and its roles in tissue repairs andregeneration. Methods The l iterature about the expression of MGF and its roles in tissue repairs and regeneration in recentyears was reviewed. Results MGF is sensitive to mechanical stimulation and can be expressed in various tissues/cells. MGF isresponsible for satell ite cell activation, myoblast proliferation, and plays important roles in the treatment of muscle coloboma,prevention of myocardial injury, and neuroprotection. Conclusion The important role of MGF in tissue repairs andregeneration has been identified, however, the detailed mechanisms remain unclear up to now and still need a further study.
目的 檢測分化抑制因子1（Id-1）在肝細胞肝癌組織中和正常肝組織中的表達情況，了解Id-1與肝細胞肝癌患者預后關系。 方法 對獲得的19例肝細胞肝癌組織標本和8例正常肝組織進行免疫組織化學染色，并對染色結果進行分級。借助SPSS軟件，分析肝細胞肝癌組織標本與正常肝組織標本中的Id-1表達強度區別，Id-1與甲胎蛋白（AFP）相關性，及Id-1表達強度與肝癌患者預后之間的關系。 結果 免疫組織化學染色結果顯示所有標本均表達為陽性，其中3例（+），7例（++），10例（+++）7例（++++），肝細胞肝癌組織標本與正常肝組織標本差異有統計學意義（P＜0.05）；Id-1表達與血液中AFP水平相關不顯著（r=?0.121，P=0.621）；Spearman等級相關分析顯示患者生存時間與Id-1表達呈負相關（r=?0.567，P=0.011）。 結論 Id-1在肝癌組織中表達增高 ，Id-1表達水平與生存時間呈負相關，但和AFP無明顯相關。