【摘要】目的探索內鏡直視下應用帶膜記憶合金支架對晚期食管、賁門惡性狹窄的介入治療方法。方法2005年1月2009年11月對49例失去手術機會或拒絕手術的晚期食管癌或賁門癌致食管或賁門狹窄患者,行電子胃鏡引導下放置鎳鈦合金支架;對狹窄程度重、胃鏡不能通過者,先行Savary探條擴張再放置支架。結果49例均成功置入支架,解除狹窄有效率達100%。結論內鏡直視下帶膜支架置入操作方法簡便、安全,可改善患者的生存質量,延長生存時間。
ObjectiveTo investigate the association between single nucleotide polymorphism (SNP) rs3754219 in the glucose transporters 1 (GLUT1) gene and genetic susceptibility to type 2 diabetes mellitus (T2DM) in Han population in Guangdong Province.MethodsA total of 1 092 T2DM patients (case group) and 1 092 healthy controls (control group) diagnosed or examined between November 2011 and October 2014 form 10 hospitals were enrolled in this study. SNPscanTM SNP classification technology was used to detect the polymorphism of rs3754219 of GLUT1 genetype. Finally, 1 067 T2DM patients and 1 054 healthy controls were included, removing 37 individuals with SNP typing deletion rates >20% and 26 individucals with failed SNP site genotyping. The differences in allele frequency distribution, genotype, and genetic models between the two groups were analyzed.ResultsAfter correction for age and body mass index, there was no statistically significant difference in allele frequency or polymorphism genotype frequency of rs3754219 (P>0.05). There was no statistically significant difference between the two groups under different genetic models (P>0.05).ConclusionGenetic susceptibility to T2DM in Han population in Guangdong Province may be unrelated to the GLUT1 rs3754219 SNP.