目的 探討丙泊酚-瑞芬太尼對肝臟缺血再灌注損傷的保護作用以及作用機制。 方法 2009年6月－2011年12月選擇擇期需阻斷肝門的肝臟手術患者40例，隨機分為丙泊酚-瑞芬太尼組（P組）和異氟醚組（I組），每組20例。在術前（T0）和肝門阻斷開放后30 min（T1）、60 min（T2）、6 h（T3）、24 h（T4）、72 h（T5）分別抽取動脈血，測定天冬氨酸氨基轉移酶（AST）、丙氨酸氨基轉移酶（ALT）和腫瘤壞死因子α（TNF-α）的含量。 結果 兩組AST、ALT、TNF-α較術前均有增高，差異有統計學意義（P＜0.05）；P組增高幅度明顯低于I組，差異有統計學意義（P＜0.05）。 結論 丙泊酚-瑞芬太尼對肝臟缺血再灌注損傷具有保護作用，抑制TNF-α的產生可能為其作用機制之一。
Sit-to-stand is an indispensable functional activity in human daily life, which requires high muscle strength, not only to control the lower limbs, but also to ensure the stable ascension of the trunk. This paper describes in detail the trajectory and speed of the joints through the human sit-to-stand test, analyzes the change rule of the angle of the joints, the angular velocity and the position of the center of mass in the human sit-to-stand, and records in detail the change of the plantar pressure of the subjects in this process. Through the study on joint motion and plantar pressure changes in the process of sit-to-stand, this paper summarizes the kinematics of human body in this process, aiming to provide a basis through the results of this paper for the design of human sit-to-stand assistive devices, which may be used in the future to analyze the sit-to-stand state of patients with lower limb disorders, and carry out the corresponding treatment and rehabilitation training.