Objective To investigate the application of the dynamic contrast enhanced MRI (DCE-MRI ) combined with magnetic resonance spectroscopy (MRS) in the diagnosis of prostate cancer. Method A total of 60 patients with prostate cancer and 60 patients with benign prostatic hyperplasia diagnoses in Sichuan Cancer Hospital from January 2011 to January 2014 were included as prostate cancer group and proliferative group respectively. Sixty healthy individuals during the same period were included as the control group. We used Siemens Avanto 1.5 T high field superconducting MRI for DCE-MRI scan and MRS scan. After the MRS scan was finished, we used the workstation spectroscopy tab spectral analysis. Eventually we got the crest lines of prostate metabolites choline (Cho), creatine (Cr) and citrate (Cit). Then we calculated Cho/Cit, (Cho+Cr)/Cit and their average. Results Comparing the signal value in 21 seconds, 1 minute, 2 minutes of DCE-MRI, the differences among the three groups were statistically significant (P<0.05). Comparing the results of spectral analysis, the differences among the three groups were statistically significant (P<0.05). The sensitivity was 89.67%, the specificity was 95.45% and the accuracy was 94.34% when using DCE-MRI combined with MRS. Conclusion DCE-MRI combined with MRS greatly improves the sensitivity, specificity and accuracy of the diagnosis of prostate cancer; it has a great application value in the diagnosis of prostate cancer.
目的 探討3D-多體素磁共振波譜（MRS）在評估腦膠質瘤手術切除程度的價值。 方法 對2011年6月－2012年4月32例腦膠質瘤患者術后行常規MRI及MRS檢查，測定分析手術周邊區域主要代謝產物N-乙酰天門冬氨酸（NAA）、膽堿（Cho）、肌酸（Cr）、Cho/NAA、Cho/Cr及NAA/Cr比值，對術后膠質瘤切除程度進行評價。同時通過術后病理檢查結果評估腫瘤切除程度，再與MRS評估結果相比較。 結果 32例中病理評估為9例全切除，23例為大部分切除；MRS評估為11例全切除，21例為大部分切除，評估結果與術后病理評估結果差異無統計學意義（P＞0.05）。 結論 MRS可以無創評價膠質瘤切除程度，為膠質瘤預后判定及進一步治療提供了重要的依據。