目的 探討環氧化酶-2（COX-2）在幽門螺桿菌（Hp）感染與非感染性胃潰瘍及胃癌的表達。 方法 選擇綿陽市404醫院消化內科2011年2月－2012年2月的門診及住院患者，用免疫組織化學方法檢測196例經胃鏡和組織病理學檢查明確為胃潰瘍（病理分型：腸上皮化生、異型增生）、胃癌及正常胃黏膜者的胃黏膜COX-2蛋白的表達，比較各病理分類之間及Hp感染與非感染之間COX-2蛋白表達的差異。 結果 胃潰瘍（腸上皮化生、異型增生）、胃癌組的炎癥細胞、腺上皮細胞、癌細胞及極少量正常黏膜上皮細胞中有COX-2表達。從正常胃黏膜-胃潰瘍（腸上皮化生、異型增生）-胃癌COX-2的陽性表達有逐漸增強的趨勢（P＜0.05）。Hp陽性組COX-2的陽性表達高于Hp陰性組（P＜0.05），胃癌組COX-2的陽性表達高于胃潰瘍組（P＜0．05）。 結論 COX-2在胃癌的表達高于胃潰瘍。Hp感染可誘導COX-2過度表達。
Objective To analyze the application research of prehabilitation in patients with lumbar degenerative spine surgery, and to review the intervention content, outcome index, and applied effect of prehabilitation of lumbar spine surgery patients, to provide references for the future clinical development of related research. Methods Guided by the methodology of scope review, systematic searches were conducted on China National Knowledge Infrastructure, Wanfang Database, VIP, China Biomedical Literature Database, PubMed, Embase, CINAHL, Web of Science, and Cochrane Library databases from the establishment of the database to June 2024, and the included literature was screened, refined and summarized. Results A total of 21 papers were included, including 15 randomized controlled trials, 5 quasi-experimental studies, and 1 retrospective study. The main components of prehabilitation included exercise, preoperative psychological support, nutritional interventions, and multiform health education; and the main outcome indicators included pain, assessment of low back function, sleep quality, anxiety and depression, and healthy quality of life.Conclusion Preoperative prehabilitation has a positive effect on patients undergoing surgery for lumbar degenerative disease, and the existing studies are heterogeneous in terms of content and outcome indicators, and the follow-up should continue to construct a more scientific and multimodal intervention program and carry out large-scale high-quality studies.