目的:探討鹽敏感性高血壓患者胰島素抵抗與脂聯素代謝異常的關系。方法:對100例高血壓患者采用急性鹽水負荷試驗,確定65例為鹽敏感性(SS)高血壓患者,35例為鹽不敏感性(NSS)高血壓患者,選定正常人50例為對照組,分別測其胰島素水平、血脂、血尿酸及脂聯素水平。結果:高血壓患者存尿酸、膽固醇、甘油三酯水平升高(Plt;0.01),SS組較NSS組的血尿酸、血膽固醇、血甘油三脂增高(Plt;0.01)。SS組脂聯素［(6.04±2.08)ng/mL］,較NSS組［(7.89±3.35)ng/mL(Plt;0.01)］降低,且SS組存在胰島素抵抗,HOMA指數分別為［2.54±0.53,2.21±0.55(Plt;0.01)］。血漿脂聯素水平與胰島素抵抗指標存在正相關,r=-0.36,(Plt;0.01)。結論:鹽敏感性高血壓患者存在胰島素抵抗及脂聯素降低,胰島素抵抗可能是其他代謝異常及脂聯素降低的基礎。
To standardize the treatment of secondary hyperparathyroidism and effectively meet the needs of practical clinical work, we gathered experts and nursing experts from Departments of Thyroid Surgery, Nephrology, Endocrinology and Metabolism, Nuclear Medicine, Ultrasound, Anesthesiology, Cardiology, and other departments at West China Hospital of Sichuan University to solicit opinions. This consensus was finally established based on published guidelines and the best evidence in Chinese and English combined with clinical practice. This consensus is intended to summarize and conclude, to the greatest extent possible, the practical issues encountered in diagnosing and treating secondary hyperparathyroidism in perioperative settings and to provide recommendations for clinical practice.