Search

Interleukin10/interleukin6 and Nuclear FactorΚAppa B Activation in Acute Coronary Syndrome and Its Clinical Significance

摘要:目的：探討急性冠脈綜合征患者血清IL-10/IL-6平及NFκB活性變化。方法：采用ELISA法檢測45例急性冠脈綜合征（ACS）患者,20例穩定性心絞痛（SAP）患者,20例非冠心病為對照者血清IL-10、IL-6水平；同時細胞免疫組化測定各組外周血單個核細胞NF-κB活性。結果: ACS組血清IL-6/IL-10 比值及NF-κB活性均高于SAP組及對照組(ACS: 1.69 ±0.53,0.32± 0.12;SAP: 1.06 ± 0.38,0.13 ±0.07;對照組: 0.92 ± 0.41,0.11±0.09, 均P＜0.05)。結論：炎癥介質及抗炎癥介質分泌失衡在急性冠脈綜合征中發揮了重要作用。Abstract: Objective: To evaluate the clinical value of Theratio IL6/IL10Interleukin10(IL10)/ interleukin6(IL6) and Nuclear factorκappa B activation in acute coronary syndrome. Methods: Serum level of IL10, IL6 were measured for 45 cases patients of acute coronary syndrome (ACS), 20 cases patients of stable angina pectoris (SAP) and 20 cases patients without Coronary heart diseas（CHD）as control group by means of Enzyme linked immune absorption assay, while NFκB Activation measured by cell immunohistochemical method In Peripheral blood monouclear cell. Results： The ratio IL6/IL10 and Nuclear factorκappa B activation were significantly higher in patients with ACS (169±053,032±012) than in those of SAP (106±038,013±007) and Control (092±041,011±009)(Plt;005). Conclusion：there was Inflammatory imbalance between IL10 and IL6 in ACS, Inflammatory effects is important to devope to acute coronary syndrome