ObjectiveTo develop a patient version of guideline for non-pharmacological interventions in breast cancer, aiming to support patients decision-making and self-management. MethodsAdhering to international guidelines and the World Health Organization's methodology for guideline development, health issues from the patient perspective were identified through sentiment dictionaries, in-depth individual interviews, and clinical surveys. Official websites of guidelines, professional association websites and comprehensive databases were systematically searched. The quality of evidence was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Resource utilization was assessed by integrating health economics evidence, and preliminary recommendations were formulated using an Evidence-to-Decision (EtD) framework. Subsequently, two rounds of online consensus meetings and one Delphi round were conducted to refine and finalize the recommendations, resulting in the final patient guideline. ResultsThe patient and public version of guideline for non-pharmacological interventions in breast cancer encompassed three modules: disease knowledge, symptoms, and psychological well-being. It covered core content, including disease awareness, wound recovery, dietary nutrition, reproductive health, symptom management, and psychological adjustment. ConclusionDeveloped from the patient perspective and based on rigorous methodological processes, the guideline formulated evidence - based recommendations, which serve as a reference for breast cancer patients in decision-making and self-management.
ObjectiveTo systematically evaluate the effects of computerized cognitive training (CCT) on cognitive function, depression, and quality of life in elderly individuals with mild cognitive impairment (MCI). MethodsEight electronic databases, Cochrane Library, Eric, PubMed, Web of Science, ProQuest, CNKI and WanFang Data, were searched from inception to June 2024. Six members of the research team independently screened the literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was performed using RevMan 5.3 software. ResultsA total of 15 studies involving 837 elderly individuals with MCI were ultimately included. The results of meta-analysis showed that: 1) Compared with no intervention/usual care, CCT significantly improved global cognitive function (SMD = 0.91, 95%CI 0.49 to 1.42, P < 0.01), memory (SMD = 0.89, 95%CI 0.33 to 1.46, P < 0.01), attention (SMD = 0.83, 95%CI 0.36 to 1.30, P < 0.01), executive function (SMD = –0.62, 95%CI –0.89 to –0.34, P < 0.01), language function (SMD = 0.69, 95%CI 0.43 to 0.96, P < 0.01), and visuospatial function (SMD = 0.46, 95%CI 0.16 to 0.76, P < 0.01); 2) Compared with active control, CCT significantly improved overall cognitive function and attention, with effects sustained in the short term. It held potential for enhancing memory, executive function, language function, and visuospatial function. ConclusionBased on low-quality evidence, this meta-analysis indicates that CCT contributes to improving global cognitive function, memory, attention, executive function, language function, and visuospatial function in older adults with MCI. The intervention effects gradually diminish over time during follow-up. Future studies should further increase sample sizes, extend follow-up periods, and adopt more rigorous methodological standards to accurately assess the effectiveness and sustainability of CCT interventions through higher-quality research.