目的 研究細胞視黃酸結合蛋白（CRABP）Ⅱ、表皮型脂肪酸結合蛋白（E-FABP）和Ki-67在乳腺浸潤性導管癌中的表達情況及三者的相關性。 方法 采用免疫組織化學檢測2001年1月－2007年12月手術切除的152例乳腺浸潤性導管癌中CRABPⅡ、E-FABP和Ki-67的表達。 結果 在浸潤性導管癌中，CRABPⅡ在Ki-67陰性組的陽性率高于Ki-67陽性組（P＜0.05），相反地，E-FABP在Ki-67陽性組的陽性率高于Ki-67陰性組（P＜0.05）。CRABPⅡ和Ki-67表達呈負相關（rS=?0.432，P＜0.05）；E-FABP和Ki-67表達呈正相關（rS=0.842， P＜0.05）。E-FABP和Ki-67的表達具有協同性，E-FABP和Ki-67共同表達與腫瘤的轉移有關（P＜0.05）。單因素生存分析顯示，E-FABP的陽性表達患者、Ki-67的陽性表達患者以及E-FABP和Ki-67的共同陽性表達患者的預后差（P＜0.05）。多因素生存分析提示E-FABP的表達（RR=4.223，P=0.012）和TNM分期（RR=8.412，P=0.000）是影響浸潤性導管癌患者預后的獨立危險因素。 結論 在乳腺浸潤性導管癌中，CRABPⅡ和E-FABP與腫瘤細胞的增殖有關，CRABPⅡ抑制細胞增殖，E-FABP促進細胞增殖。E-FABP和Ki-67在浸潤性導管癌的發生、發展中起協同作用，兩者的陽性表達可能對評估腫瘤的轉移和患者的預后有一定價值。
ObjectiveTo summarize our experience of critical congenital heart diseases treatment system for the newborn and to report its surgical results.MethodsWe reviewed the clinical data of 97 neonates with congenital heart diseases who admitted to pediatric cardiac center from January 2019 to August 2020 in our hospital. The patients were divided into a prenatal and postnatal diagnosis and treatment integration group (integrated group, n=41), and a postnatal diagnosis and rapid admission by green channel group (non-integrated group, n=56).ResultsThe age of admission in the integrated group was younger than that in the non-integrated group (3.0 d vs. 11.0 d, P<0.001), and the weight was lighter (3.3±0.4 kg vs. 3.6±0.6 kg, P=0.006), operation age was younger (13.0 d vs. 17.5 d, P=0.004), proportion of palliative surgery was smaller (2.4% vs. 8.9%, P=0.396), time for ventilator assistance was longer (153.0 h vs. 65.0 h, P=0.020), hospital mortality was lower (0.0% vs. 7.1%, P=0.135). There was no significant difference in the follow-up (11.0 months vs. 12 months, P=1.000), out-of-hospital mortality (2.4% vs. 1.8%, P=1.000) and total mortality (2.4% vs. 8.9%, P=0.396) between the two groups.ConclusionPrenatal and postnatal diagnosis and treatment integration can significantly shorten the diagnosis and the hospitalization interval of newborn, that surgical intervention could be performed timely. It can reduce the risk of death before surgery but need longer time for recovery after surgery. Patients with postnatal diagnosis and admitted hospital through green channel also can get perfect results if surgical intervention is performed timely.